SARS-CoV-2 Spike-Heat Shock Protein A5 (GRP78) Recognition may be Related to the Immersed Human Coronaviruses
The human coronavirus (HCoV), SARS-CoV-2, caused more than 34 M confirmed infections from which more than 1 M deaths are reported until now (the WHO situation report-154). The current pandemic causes severe socio-economic burden. Due to the importance of understanding of the mode of recognition and...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-12-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2020.577467/full |
| _version_ | 1819175568822763520 |
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| author | Abdo A. Elfiky |
| author_facet | Abdo A. Elfiky |
| author_sort | Abdo A. Elfiky |
| collection | DOAJ |
| description | The human coronavirus (HCoV), SARS-CoV-2, caused more than 34 M confirmed infections from which more than 1 M deaths are reported until now (the WHO situation report-154). The current pandemic causes severe socio-economic burden. Due to the importance of understanding of the mode of recognition and viral entry, spike protein shed drug designers as the first look protein target with the first released solved structure on 26 February 2020 (PDB ID: 6VSB). It is proposed that the recognition site for GRP78 is found in SARS-CoV-2 and the immersed human coronaviruses but experimental validation is still required. |
| first_indexed | 2024-12-22T20:56:57Z |
| format | Article |
| id | doaj.art-00c258286ec7463092c7e0c83dc30f5e |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-12-22T20:56:57Z |
| publishDate | 2020-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-00c258286ec7463092c7e0c83dc30f5e2022-12-21T18:12:56ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122020-12-011110.3389/fphar.2020.577467577467SARS-CoV-2 Spike-Heat Shock Protein A5 (GRP78) Recognition may be Related to the Immersed Human CoronavirusesAbdo A. ElfikyThe human coronavirus (HCoV), SARS-CoV-2, caused more than 34 M confirmed infections from which more than 1 M deaths are reported until now (the WHO situation report-154). The current pandemic causes severe socio-economic burden. Due to the importance of understanding of the mode of recognition and viral entry, spike protein shed drug designers as the first look protein target with the first released solved structure on 26 February 2020 (PDB ID: 6VSB). It is proposed that the recognition site for GRP78 is found in SARS-CoV-2 and the immersed human coronaviruses but experimental validation is still required.https://www.frontiersin.org/articles/10.3389/fphar.2020.577467/fullGRP78HSPA5SARS-CoV-2viral attachmentspikehost-cell recognition |
| spellingShingle | Abdo A. Elfiky SARS-CoV-2 Spike-Heat Shock Protein A5 (GRP78) Recognition may be Related to the Immersed Human Coronaviruses Frontiers in Pharmacology GRP78 HSPA5 SARS-CoV-2 viral attachment spike host-cell recognition |
| title | SARS-CoV-2 Spike-Heat Shock Protein A5 (GRP78) Recognition may be Related to the Immersed Human Coronaviruses |
| title_full | SARS-CoV-2 Spike-Heat Shock Protein A5 (GRP78) Recognition may be Related to the Immersed Human Coronaviruses |
| title_fullStr | SARS-CoV-2 Spike-Heat Shock Protein A5 (GRP78) Recognition may be Related to the Immersed Human Coronaviruses |
| title_full_unstemmed | SARS-CoV-2 Spike-Heat Shock Protein A5 (GRP78) Recognition may be Related to the Immersed Human Coronaviruses |
| title_short | SARS-CoV-2 Spike-Heat Shock Protein A5 (GRP78) Recognition may be Related to the Immersed Human Coronaviruses |
| title_sort | sars cov 2 spike heat shock protein a5 grp78 recognition may be related to the immersed human coronaviruses |
| topic | GRP78 HSPA5 SARS-CoV-2 viral attachment spike host-cell recognition |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2020.577467/full |
| work_keys_str_mv | AT abdoaelfiky sarscov2spikeheatshockproteina5grp78recognitionmayberelatedtotheimmersedhumancoronaviruses |