Senescent Tumor CD8<sup>+</sup> T Cells: Mechanisms of Induction and Challenges to Immunotherapy
The inability of tumor-infiltrating T lymphocytes to eradicate tumor cells within the tumor microenvironment (TME) is a major obstacle to successful immunotherapeutic treatments. Understanding the immunosuppressive mechanisms within the TME is paramount to overcoming these obstacles. T cell senescen...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-09-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/12/10/2828 |
| _version_ | 1797552124905652224 |
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| author | Wei Liu Paweł Stachura Haifeng C. Xu Sanil Bhatia Arndt Borkhardt Philipp A. Lang Aleksandra A. Pandyra |
| author_facet | Wei Liu Paweł Stachura Haifeng C. Xu Sanil Bhatia Arndt Borkhardt Philipp A. Lang Aleksandra A. Pandyra |
| author_sort | Wei Liu |
| collection | DOAJ |
| description | The inability of tumor-infiltrating T lymphocytes to eradicate tumor cells within the tumor microenvironment (TME) is a major obstacle to successful immunotherapeutic treatments. Understanding the immunosuppressive mechanisms within the TME is paramount to overcoming these obstacles. T cell senescence is a critical dysfunctional state present in the TME that differs from T cell exhaustion currently targeted by many immunotherapies. This review focuses on the physiological, molecular, metabolic and cellular processes that drive CD8<sup>+</sup> T cell senescence. Evidence showing that senescent T cells hinder immunotherapies is discussed, as are therapeutic options to reverse T cell senescence. |
| first_indexed | 2024-03-10T15:55:30Z |
| format | Article |
| id | doaj.art-00c2d031f5054e63ae35f066af14f773 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T15:55:30Z |
| publishDate | 2020-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-00c2d031f5054e63ae35f066af14f7732023-11-20T15:40:51ZengMDPI AGCancers2072-66942020-09-011210282810.3390/cancers12102828Senescent Tumor CD8<sup>+</sup> T Cells: Mechanisms of Induction and Challenges to ImmunotherapyWei Liu0Paweł Stachura1Haifeng C. Xu2Sanil Bhatia3Arndt Borkhardt4Philipp A. Lang5Aleksandra A. Pandyra6Department of Molecular Medicine II, Medical Faculty, Heinrich-Heine-University, 40225 Düsseldorf, GermanyDepartment of Molecular Medicine II, Medical Faculty, Heinrich-Heine-University, 40225 Düsseldorf, GermanyDepartment of Molecular Medicine II, Medical Faculty, Heinrich-Heine-University, 40225 Düsseldorf, GermanyDepartment of Pediatric Oncology, Hematology and Clinical Immunology, Medical Faculty, Center of Child and Adolescent Health, Heinrich-Heine-University, 40225 Düsseldorf, GermanyDepartment of Pediatric Oncology, Hematology and Clinical Immunology, Medical Faculty, Center of Child and Adolescent Health, Heinrich-Heine-University, 40225 Düsseldorf, GermanyDepartment of Molecular Medicine II, Medical Faculty, Heinrich-Heine-University, 40225 Düsseldorf, GermanyDepartment of Molecular Medicine II, Medical Faculty, Heinrich-Heine-University, 40225 Düsseldorf, GermanyThe inability of tumor-infiltrating T lymphocytes to eradicate tumor cells within the tumor microenvironment (TME) is a major obstacle to successful immunotherapeutic treatments. Understanding the immunosuppressive mechanisms within the TME is paramount to overcoming these obstacles. T cell senescence is a critical dysfunctional state present in the TME that differs from T cell exhaustion currently targeted by many immunotherapies. This review focuses on the physiological, molecular, metabolic and cellular processes that drive CD8<sup>+</sup> T cell senescence. Evidence showing that senescent T cells hinder immunotherapies is discussed, as are therapeutic options to reverse T cell senescence.https://www.mdpi.com/2072-6694/12/10/2828CD8<sup>+</sup> T cellssenescenceimmunotherapymetabolism |
| spellingShingle | Wei Liu Paweł Stachura Haifeng C. Xu Sanil Bhatia Arndt Borkhardt Philipp A. Lang Aleksandra A. Pandyra Senescent Tumor CD8<sup>+</sup> T Cells: Mechanisms of Induction and Challenges to Immunotherapy Cancers CD8<sup>+</sup> T cells senescence immunotherapy metabolism |
| title | Senescent Tumor CD8<sup>+</sup> T Cells: Mechanisms of Induction and Challenges to Immunotherapy |
| title_full | Senescent Tumor CD8<sup>+</sup> T Cells: Mechanisms of Induction and Challenges to Immunotherapy |
| title_fullStr | Senescent Tumor CD8<sup>+</sup> T Cells: Mechanisms of Induction and Challenges to Immunotherapy |
| title_full_unstemmed | Senescent Tumor CD8<sup>+</sup> T Cells: Mechanisms of Induction and Challenges to Immunotherapy |
| title_short | Senescent Tumor CD8<sup>+</sup> T Cells: Mechanisms of Induction and Challenges to Immunotherapy |
| title_sort | senescent tumor cd8 sup sup t cells mechanisms of induction and challenges to immunotherapy |
| topic | CD8<sup>+</sup> T cells senescence immunotherapy metabolism |
| url | https://www.mdpi.com/2072-6694/12/10/2828 |
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