Senescent Tumor CD8<sup>+</sup> T Cells: Mechanisms of Induction and Challenges to Immunotherapy

Senescent Tumor CD8<sup>+</sup> T Cells: Mechanisms of Induction and Challenges to Immunotherapy

The inability of tumor-infiltrating T lymphocytes to eradicate tumor cells within the tumor microenvironment (TME) is a major obstacle to successful immunotherapeutic treatments. Understanding the immunosuppressive mechanisms within the TME is paramount to overcoming these obstacles. T cell senescen...

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Bibliographic Details
Main Authors: Wei Liu, Paweł Stachura, Haifeng C. Xu, Sanil Bhatia, Arndt Borkhardt, Philipp A. Lang, Aleksandra A. Pandyra
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:Cancers
Subjects:
CD8<sup>+</sup> T cells
senescence
immunotherapy
metabolism
Online Access:https://www.mdpi.com/2072-6694/12/10/2828

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