Control of Capsid Transformations during Reovirus Entry
Mammalian orthoreovirus (reovirus), a dsRNA virus with a multilayered capsid, serves as a model system for studying the entry of similar viruses. The outermost layer of this capsid undergoes processing to generate a metastable intermediate. The metastable particle undergoes further remodeling to gen...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-01-01
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| Series: | Viruses |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1999-4915/13/2/153 |
| _version_ | 1827598942385209344 |
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| author | Stephanie L. Gummersheimer Anthony J. Snyder Pranav Danthi |
| author_facet | Stephanie L. Gummersheimer Anthony J. Snyder Pranav Danthi |
| author_sort | Stephanie L. Gummersheimer |
| collection | DOAJ |
| description | Mammalian orthoreovirus (reovirus), a dsRNA virus with a multilayered capsid, serves as a model system for studying the entry of similar viruses. The outermost layer of this capsid undergoes processing to generate a metastable intermediate. The metastable particle undergoes further remodeling to generate an entry-capable form that delivers the genome-containing inner capsid, or core, into the cytoplasm. In this review, we highlight capsid proteins and the intricacies of their interactions that control the stability of the capsid and consequently impact capsid structural changes that are prerequisites for entry. We also discuss a novel proviral role of host membranes in promoting capsid conformational transitions. Current knowledge gaps in the field that are ripe for future investigation are also outlined. |
| first_indexed | 2024-03-09T04:03:07Z |
| format | Article |
| id | doaj.art-00c320c88d2f4ff8a653ac79163973f5 |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-03-09T04:03:07Z |
| publishDate | 2021-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-00c320c88d2f4ff8a653ac79163973f52023-12-03T14:09:52ZengMDPI AGViruses1999-49152021-01-0113215310.3390/v13020153Control of Capsid Transformations during Reovirus EntryStephanie L. Gummersheimer0Anthony J. Snyder1Pranav Danthi2Department of Biology, Indiana University, Bloomington, IN 47405, USADepartment of Biology, Indiana University, Bloomington, IN 47405, USADepartment of Biology, Indiana University, Bloomington, IN 47405, USAMammalian orthoreovirus (reovirus), a dsRNA virus with a multilayered capsid, serves as a model system for studying the entry of similar viruses. The outermost layer of this capsid undergoes processing to generate a metastable intermediate. The metastable particle undergoes further remodeling to generate an entry-capable form that delivers the genome-containing inner capsid, or core, into the cytoplasm. In this review, we highlight capsid proteins and the intricacies of their interactions that control the stability of the capsid and consequently impact capsid structural changes that are prerequisites for entry. We also discuss a novel proviral role of host membranes in promoting capsid conformational transitions. Current knowledge gaps in the field that are ripe for future investigation are also outlined.https://www.mdpi.com/1999-4915/13/2/153reoviruscell entrycapsid |
| spellingShingle | Stephanie L. Gummersheimer Anthony J. Snyder Pranav Danthi Control of Capsid Transformations during Reovirus Entry Viruses reovirus cell entry capsid |
| title | Control of Capsid Transformations during Reovirus Entry |
| title_full | Control of Capsid Transformations during Reovirus Entry |
| title_fullStr | Control of Capsid Transformations during Reovirus Entry |
| title_full_unstemmed | Control of Capsid Transformations during Reovirus Entry |
| title_short | Control of Capsid Transformations during Reovirus Entry |
| title_sort | control of capsid transformations during reovirus entry |
| topic | reovirus cell entry capsid |
| url | https://www.mdpi.com/1999-4915/13/2/153 |
| work_keys_str_mv | AT stephanielgummersheimer controlofcapsidtransformationsduringreovirusentry AT anthonyjsnyder controlofcapsidtransformationsduringreovirusentry AT pranavdanthi controlofcapsidtransformationsduringreovirusentry |