Potentially Inappropriate Prescribing and Potential Prescribing Omissions and Their Association with Adverse Drug Reaction-Related Hospital Admissions
Background: This study aimed to determine the prevalence of potentially inappropriate prescribing (PIP) and potential prescribing omissions (PPOs) and their association with ADR-related hospital admissions in patients aged ≥ 65 years admitted acutely to the hospital. Methods: Information on medicati...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-01-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/13/2/323 |
| _version_ | 1797339720257110016 |
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| author | Ross Brannigan John E. Hughes Frank Moriarty Emma Wallace Ciara Kirke David Williams Kathleen Bennett Caitriona Cahir |
| author_facet | Ross Brannigan John E. Hughes Frank Moriarty Emma Wallace Ciara Kirke David Williams Kathleen Bennett Caitriona Cahir |
| author_sort | Ross Brannigan |
| collection | DOAJ |
| description | Background: This study aimed to determine the prevalence of potentially inappropriate prescribing (PIP) and potential prescribing omissions (PPOs) and their association with ADR-related hospital admissions in patients aged ≥ 65 years admitted acutely to the hospital. Methods: Information on medications and morbidities was extracted from the Adverse Drug Reactions in an Ageing Population (ADAPT) cohort (N = 798: N = 361 ADR-related admissions; 437 non-ADR-related admissions). PIP and PPOs were assessed using Beers Criteria 2019 and STOPP/START version 2. Multivariable logistic regression (adjusted odds ratios (aOR), 95%CI) was used to examine the association between PIP, PPOs and ADR-related admissions, adjusting for covariates (age, gender, comorbidity, polypharmacy). Results: In total, 715 (90%; 95% CI 87–92%) patients had ≥1 Beers Criteria, 555 (70%; 95% CI 66–73%) had ≥ 1 STOPP criteria and 666 patients (83%; 95% CI 81–86%) had ≥ 1 START criteria. Being prescribed at least one Beers (aOR = 1.66, 95% CI = 1.00–2.77), or meeting STOPP (aOR = 1.07, 95% CI = 0.79–1.45) or START (aOR = 0.72; 95%CI = 0.50–1.06) criteria or the number of PIP/PPO criteria met was not significantly associated with ADR-related admissions. Patients prescribed certain drug classes (e.g., antiplatelet agents, diuretics) per individual PIP criteria were more likely to have an ADR-related admission. Conclusion: There was a high prevalence of PIP and PPOs in this cohort but no association with ADR-related admissions. |
| first_indexed | 2024-03-08T09:51:29Z |
| format | Article |
| id | doaj.art-00c5abb1e494401c9ec75709855f6568 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-08T09:51:29Z |
| publishDate | 2024-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-00c5abb1e494401c9ec75709855f65682024-01-29T14:00:40ZengMDPI AGJournal of Clinical Medicine2077-03832024-01-0113232310.3390/jcm13020323Potentially Inappropriate Prescribing and Potential Prescribing Omissions and Their Association with Adverse Drug Reaction-Related Hospital AdmissionsRoss Brannigan0John E. Hughes1Frank Moriarty2Emma Wallace3Ciara Kirke4David Williams5Kathleen Bennett6Caitriona Cahir7School of Population Health, RCSI University of Medicine and Health Sciences, D02 YN77 Dublin, IrelandSchool of Population Health, RCSI University of Medicine and Health Sciences, D02 YN77 Dublin, IrelandSchool of Pharmacy and Biomolecular Sciences, RCSI University of Medicine and Health Sciences, D02 YN77 Dublin, IrelandDepartment of General Practice, University College Cork, T12 R229 Cork, IrelandNational Quality and Patient Safety Directorate at Health Service Executive, D08 W2A8 Dublin, IrelandDepartment of Geriatric and Stroke Medicine, RCSI University of Medicine and Health Sciences, D02 YN77 Dublin, IrelandSchool of Population Health, RCSI University of Medicine and Health Sciences, D02 YN77 Dublin, IrelandSchool of Population Health, RCSI University of Medicine and Health Sciences, D02 YN77 Dublin, IrelandBackground: This study aimed to determine the prevalence of potentially inappropriate prescribing (PIP) and potential prescribing omissions (PPOs) and their association with ADR-related hospital admissions in patients aged ≥ 65 years admitted acutely to the hospital. Methods: Information on medications and morbidities was extracted from the Adverse Drug Reactions in an Ageing Population (ADAPT) cohort (N = 798: N = 361 ADR-related admissions; 437 non-ADR-related admissions). PIP and PPOs were assessed using Beers Criteria 2019 and STOPP/START version 2. Multivariable logistic regression (adjusted odds ratios (aOR), 95%CI) was used to examine the association between PIP, PPOs and ADR-related admissions, adjusting for covariates (age, gender, comorbidity, polypharmacy). Results: In total, 715 (90%; 95% CI 87–92%) patients had ≥1 Beers Criteria, 555 (70%; 95% CI 66–73%) had ≥ 1 STOPP criteria and 666 patients (83%; 95% CI 81–86%) had ≥ 1 START criteria. Being prescribed at least one Beers (aOR = 1.66, 95% CI = 1.00–2.77), or meeting STOPP (aOR = 1.07, 95% CI = 0.79–1.45) or START (aOR = 0.72; 95%CI = 0.50–1.06) criteria or the number of PIP/PPO criteria met was not significantly associated with ADR-related admissions. Patients prescribed certain drug classes (e.g., antiplatelet agents, diuretics) per individual PIP criteria were more likely to have an ADR-related admission. Conclusion: There was a high prevalence of PIP and PPOs in this cohort but no association with ADR-related admissions.https://www.mdpi.com/2077-0383/13/2/323potentially inappropriate prescribingpotential prescribing omissionsadverse drug reactionshospital admissionsolder populations |
| spellingShingle | Ross Brannigan John E. Hughes Frank Moriarty Emma Wallace Ciara Kirke David Williams Kathleen Bennett Caitriona Cahir Potentially Inappropriate Prescribing and Potential Prescribing Omissions and Their Association with Adverse Drug Reaction-Related Hospital Admissions Journal of Clinical Medicine potentially inappropriate prescribing potential prescribing omissions adverse drug reactions hospital admissions older populations |
| title | Potentially Inappropriate Prescribing and Potential Prescribing Omissions and Their Association with Adverse Drug Reaction-Related Hospital Admissions |
| title_full | Potentially Inappropriate Prescribing and Potential Prescribing Omissions and Their Association with Adverse Drug Reaction-Related Hospital Admissions |
| title_fullStr | Potentially Inappropriate Prescribing and Potential Prescribing Omissions and Their Association with Adverse Drug Reaction-Related Hospital Admissions |
| title_full_unstemmed | Potentially Inappropriate Prescribing and Potential Prescribing Omissions and Their Association with Adverse Drug Reaction-Related Hospital Admissions |
| title_short | Potentially Inappropriate Prescribing and Potential Prescribing Omissions and Their Association with Adverse Drug Reaction-Related Hospital Admissions |
| title_sort | potentially inappropriate prescribing and potential prescribing omissions and their association with adverse drug reaction related hospital admissions |
| topic | potentially inappropriate prescribing potential prescribing omissions adverse drug reactions hospital admissions older populations |
| url | https://www.mdpi.com/2077-0383/13/2/323 |
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