Current challenges and nanotechnology-based pharmaceutical strategies for the treatment and control of malaria
Malaria is one of the prevalent tropical diseases caused by the parasitic protozoan of the genus Plasmodium spp. With an estimated 228 million cases, it is a major public health concern with high incidence of morbidity and mortality worldwide. The emergence of drug-resistant parasites, inadequate ve...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-05-01
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| Series: | Parasite Epidemiology and Control |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405673122000083 |
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| author | Lohitha Gujjari Hamed Kalani Sai Kiran Pindiprolu Bhanu Prakash Arakareddy Ganesh Yadagiri |
| author_facet | Lohitha Gujjari Hamed Kalani Sai Kiran Pindiprolu Bhanu Prakash Arakareddy Ganesh Yadagiri |
| author_sort | Lohitha Gujjari |
| collection | DOAJ |
| description | Malaria is one of the prevalent tropical diseases caused by the parasitic protozoan of the genus Plasmodium spp. With an estimated 228 million cases, it is a major public health concern with high incidence of morbidity and mortality worldwide. The emergence of drug-resistant parasites, inadequate vector control measures, and the non-availability of effective vaccine(s) against malaria pose a serious challenge to malaria eradication especially in underdeveloped and developing countries. Malaria treatment and control comprehensively relies on chemical compounds, which encompass various complications, including severe toxic effects, emergence of drug resistance, and high cost of therapy. To overcome the clinical failures of anti-malarial chemotherapy, a new drug development is of an immediate need. However, the drug discovery and development process is expensive and time consuming. In such a scenario, nanotechnological strategies may offer promising alternative approach for the treatment and control of malaria, with improved efficacy and safety. Nanotechnology based formulations of existing anti-malarial chemotherapeutic agents prove to exceed the limitations of existing therapies in relation to optimum therapeutic benefits, safety, and cost effectiveness, which indeed advances the patient's compliance in treatment. In this review, the shortcomings of malaria therapeutics and necessity of nanotechnological strategies for treating malaria were discussed. |
| first_indexed | 2024-04-14T06:53:55Z |
| format | Article |
| id | doaj.art-00c6e44f4c5244948f295f1b83f2d3cc |
| institution | Directory Open Access Journal |
| issn | 2405-6731 |
| language | English |
| last_indexed | 2024-04-14T06:53:55Z |
| publishDate | 2022-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Parasite Epidemiology and Control |
| spelling | doaj.art-00c6e44f4c5244948f295f1b83f2d3cc2022-12-22T02:06:57ZengElsevierParasite Epidemiology and Control2405-67312022-05-0117e00244Current challenges and nanotechnology-based pharmaceutical strategies for the treatment and control of malariaLohitha Gujjari0Hamed Kalani1Sai Kiran Pindiprolu2Bhanu Prakash Arakareddy3Ganesh Yadagiri4Centre of Infectious Diseases, Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research, S. A. S. Nagar, Punjab 160 062, India; Department of Entomology, The Ohio State University, Ohio Agricultural Research and Development Center, 1680 Madison Avenue, Wooster, OH 44691, USAInfectious Diseases Research Center, Golestan University of Medical Sciences, Gorgan, IranDepartment of Pharmacology, School of Pharmaceutical Sciences and Technologies, Jawaharlal Nehru Technological University, Kakinada, Andhra Pradesh 533003, IndiaDepartment of Pharmacology, Bharat School of Pharmacy, Mangalpally, Telengana 501510, IndiaDepartment of Pharmacology, School of Pharmaceutical Sciences and Technologies, Jawaharlal Nehru Technological University, Kakinada, Andhra Pradesh 533003, India; Centre for Food Animal Health, The Ohio State University, Ohio Agricultural Research and Development Center, 1680 Madison Avenue, Wooster, OH 44691, USA; Corresponding author at: Department of Pharmacology, School of Pharmaceutical Sciences and Technologies, Jawaharlal Nehru Technological University, Kakinada, Andhra Pradesh 533003, India.Malaria is one of the prevalent tropical diseases caused by the parasitic protozoan of the genus Plasmodium spp. With an estimated 228 million cases, it is a major public health concern with high incidence of morbidity and mortality worldwide. The emergence of drug-resistant parasites, inadequate vector control measures, and the non-availability of effective vaccine(s) against malaria pose a serious challenge to malaria eradication especially in underdeveloped and developing countries. Malaria treatment and control comprehensively relies on chemical compounds, which encompass various complications, including severe toxic effects, emergence of drug resistance, and high cost of therapy. To overcome the clinical failures of anti-malarial chemotherapy, a new drug development is of an immediate need. However, the drug discovery and development process is expensive and time consuming. In such a scenario, nanotechnological strategies may offer promising alternative approach for the treatment and control of malaria, with improved efficacy and safety. Nanotechnology based formulations of existing anti-malarial chemotherapeutic agents prove to exceed the limitations of existing therapies in relation to optimum therapeutic benefits, safety, and cost effectiveness, which indeed advances the patient's compliance in treatment. In this review, the shortcomings of malaria therapeutics and necessity of nanotechnological strategies for treating malaria were discussed.http://www.sciencedirect.com/science/article/pii/S2405673122000083Anti-malarialsChemotherapyDrug resistanceEfficacyMalariaNanotechnological approaches |
| spellingShingle | Lohitha Gujjari Hamed Kalani Sai Kiran Pindiprolu Bhanu Prakash Arakareddy Ganesh Yadagiri Current challenges and nanotechnology-based pharmaceutical strategies for the treatment and control of malaria Parasite Epidemiology and Control Anti-malarials Chemotherapy Drug resistance Efficacy Malaria Nanotechnological approaches |
| title | Current challenges and nanotechnology-based pharmaceutical strategies for the treatment and control of malaria |
| title_full | Current challenges and nanotechnology-based pharmaceutical strategies for the treatment and control of malaria |
| title_fullStr | Current challenges and nanotechnology-based pharmaceutical strategies for the treatment and control of malaria |
| title_full_unstemmed | Current challenges and nanotechnology-based pharmaceutical strategies for the treatment and control of malaria |
| title_short | Current challenges and nanotechnology-based pharmaceutical strategies for the treatment and control of malaria |
| title_sort | current challenges and nanotechnology based pharmaceutical strategies for the treatment and control of malaria |
| topic | Anti-malarials Chemotherapy Drug resistance Efficacy Malaria Nanotechnological approaches |
| url | http://www.sciencedirect.com/science/article/pii/S2405673122000083 |
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