EXPERIENCE WITH INTRAPERITONEAL CHEMOTHERAPY USING ASCITIC FLUID AS A SOLVENT OF CHEMICALS IN THE TREATMENT OF OVARIAN CANCER
Thirty two with the ascitic form of Stages IIIC—IV ovarian cancer underwent 1 to 3 courses of intraperitoneal multidrug therapy using a protein ascitic fluid concentrate (PAFC) as a solvent of drugs (cisplatin, cyclophosphan, doxorubicin) according to the CAP regimen. The induction chemotherapy allo...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | Russian |
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ABV-press
2014-09-01
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| Series: | Опухоли женской репродуктивной системы |
| Subjects: | |
| Online Access: | https://ojrs.abvpress.ru/ojrs/article/view/301 |
| _version_ | 1826557313291386880 |
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| author | Yu. S. Sidorenko G. A. Nerodo A. P. Menshenina L. Yu. Golotina N. D. Ushakova |
| author_facet | Yu. S. Sidorenko G. A. Nerodo A. P. Menshenina L. Yu. Golotina N. D. Ushakova |
| author_sort | Yu. S. Sidorenko |
| collection | DOAJ |
| description | Thirty two with the ascitic form of Stages IIIC—IV ovarian cancer underwent 1 to 3 courses of intraperitoneal multidrug therapy using a protein ascitic fluid concentrate (PAFC) as a solvent of drugs (cisplatin, cyclophosphan, doxorubicin) according to the CAP regimen. The induction chemotherapy allowed remission to be achieved in 78.1% of cases (against 40% with standard intraperitoneal therapy), the stan- dard volume of surgical treatment was performed in 28 (87.5%) patients (21 (70%) receiving the control regime); with the use of PAFC, the size of minimum residual tumour (less than 1 cm) was achieved in 81.3% versus 63.3% with standard intraperitoneal chemotherapy. This treatment enables the use large-dose chemotherapy regimens that cause no severe systemic toxic reactions. The method is highly-effective, low-toxic and may be recommended for the treatment of patients with the ascitic form of Stages III—IV ovarian cancer. |
| first_indexed | 2024-04-10T01:57:07Z |
| format | Article |
| id | doaj.art-00ca13f9373e4afb96f3479271f68ccc |
| institution | Directory Open Access Journal |
| issn | 1994-4098 1999-8627 |
| language | Russian |
| last_indexed | 2025-03-14T08:26:37Z |
| publishDate | 2014-09-01 |
| publisher | ABV-press |
| record_format | Article |
| series | Опухоли женской репродуктивной системы |
| spelling | doaj.art-00ca13f9373e4afb96f3479271f68ccc2025-03-02T13:05:31ZrusABV-pressОпухоли женской репродуктивной системы1994-40981999-86272014-09-0101-29810210.17650/1994-4098-2009-0-1-2-98-102317EXPERIENCE WITH INTRAPERITONEAL CHEMOTHERAPY USING ASCITIC FLUID AS A SOLVENT OF CHEMICALS IN THE TREATMENT OF OVARIAN CANCERYu. S. Sidorenko0G. A. Nerodo1A. P. Menshenina2L. Yu. Golotina3N. D. Ushakova4Rostov Cancer Research Institute, Russian Agency for Medical TechnologiesRostov Cancer Research Institute, Russian Agency for Medical TechnologiesRostov Cancer Research Institute, Russian Agency for Medical TechnologiesRostov Cancer Research Institute, Russian Agency for Medical TechnologiesRostov Cancer Research Institute, Russian Agency for Medical TechnologiesThirty two with the ascitic form of Stages IIIC—IV ovarian cancer underwent 1 to 3 courses of intraperitoneal multidrug therapy using a protein ascitic fluid concentrate (PAFC) as a solvent of drugs (cisplatin, cyclophosphan, doxorubicin) according to the CAP regimen. The induction chemotherapy allowed remission to be achieved in 78.1% of cases (against 40% with standard intraperitoneal therapy), the stan- dard volume of surgical treatment was performed in 28 (87.5%) patients (21 (70%) receiving the control regime); with the use of PAFC, the size of minimum residual tumour (less than 1 cm) was achieved in 81.3% versus 63.3% with standard intraperitoneal chemotherapy. This treatment enables the use large-dose chemotherapy regimens that cause no severe systemic toxic reactions. The method is highly-effective, low-toxic and may be recommended for the treatment of patients with the ascitic form of Stages III—IV ovarian cancer.https://ojrs.abvpress.ru/ojrs/article/view/301ovarian cancerascitesintraperitoneal chemotherapy |
| spellingShingle | Yu. S. Sidorenko G. A. Nerodo A. P. Menshenina L. Yu. Golotina N. D. Ushakova EXPERIENCE WITH INTRAPERITONEAL CHEMOTHERAPY USING ASCITIC FLUID AS A SOLVENT OF CHEMICALS IN THE TREATMENT OF OVARIAN CANCER Опухоли женской репродуктивной системы ovarian cancer ascites intraperitoneal chemotherapy |
| title | EXPERIENCE WITH INTRAPERITONEAL CHEMOTHERAPY USING ASCITIC FLUID AS A SOLVENT OF CHEMICALS IN THE TREATMENT OF OVARIAN CANCER |
| title_full | EXPERIENCE WITH INTRAPERITONEAL CHEMOTHERAPY USING ASCITIC FLUID AS A SOLVENT OF CHEMICALS IN THE TREATMENT OF OVARIAN CANCER |
| title_fullStr | EXPERIENCE WITH INTRAPERITONEAL CHEMOTHERAPY USING ASCITIC FLUID AS A SOLVENT OF CHEMICALS IN THE TREATMENT OF OVARIAN CANCER |
| title_full_unstemmed | EXPERIENCE WITH INTRAPERITONEAL CHEMOTHERAPY USING ASCITIC FLUID AS A SOLVENT OF CHEMICALS IN THE TREATMENT OF OVARIAN CANCER |
| title_short | EXPERIENCE WITH INTRAPERITONEAL CHEMOTHERAPY USING ASCITIC FLUID AS A SOLVENT OF CHEMICALS IN THE TREATMENT OF OVARIAN CANCER |
| title_sort | experience with intraperitoneal chemotherapy using ascitic fluid as a solvent of chemicals in the treatment of ovarian cancer |
| topic | ovarian cancer ascites intraperitoneal chemotherapy |
| url | https://ojrs.abvpress.ru/ojrs/article/view/301 |
| work_keys_str_mv | AT yussidorenko experiencewithintraperitonealchemotherapyusingasciticfluidasasolventofchemicalsinthetreatmentofovariancancer AT ganerodo experiencewithintraperitonealchemotherapyusingasciticfluidasasolventofchemicalsinthetreatmentofovariancancer AT apmenshenina experiencewithintraperitonealchemotherapyusingasciticfluidasasolventofchemicalsinthetreatmentofovariancancer AT lyugolotina experiencewithintraperitonealchemotherapyusingasciticfluidasasolventofchemicalsinthetreatmentofovariancancer AT ndushakova experiencewithintraperitonealchemotherapyusingasciticfluidasasolventofchemicalsinthetreatmentofovariancancer |