Resveratrol Alleviates Dextran Sulfate Sodium-Induced Acute Ulcerative Colitis in Mice by Mediating PI3K/Akt/VEGFA Pathway

Resveratrol Alleviates Dextran Sulfate Sodium-Induced Acute Ulcerative Colitis in Mice by Mediating PI3K/Akt/VEGFA Pathway

Ulcerative colitis (UC) is a chronic inflammatory disease that affects the colon, and its incidence is on the rise worldwide. Resveratrol (RSV), a polyphenolic compound, was recently indicated to exert anti-inflammatory effects on UC. Consequently, the current study was conducted to investigate the...

Full description

Bibliographic Details
Main Authors:	Fang Zhu, Jujia Zheng, Fang Xu, Yiyuan Xi, Jun Chen, Xiangwei Xu
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2021-08-01
Series:	Frontiers in Pharmacology
Subjects:	resveratrol ulcerative colitis phosphoinositide 3-kinase protein kinase B vascular endothelial growth factor A
Online Access:	https://www.frontiersin.org/articles/10.3389/fphar.2021.693982/full

Similar Items

Erratum: Resveratrol Alleviates Dextran Sulfate Sodium-Induced Acute Ulcerative Colitis in Mice by Mediating PI3K/Akt/ VEGFA Pathway
by: Frontiers Production Office
Published: (2021-11-01)

Resveratrol against 6-OHDA-induced damage of PC12 cells via PI3K/Akt
by: Huang Nanqu, et al.
Published: (2021-04-01)

Reducing PDK1/Akt Activity: An Effective Therapeutic Target in the Treatment of Alzheimer’s Disease
by: Shaobin Yang, et al.
Published: (2022-05-01)

Resveratrol Exerts Anti-Osteoarthritic Effect by Inhibiting TLR4/NF-κB Signaling Pathway via the TLR4/Akt/FoxO1 Axis in IL-1β-Stimulated SW1353 Cells
by: Xu X, et al.
Published: (2020-05-01)

Glutamine relieves oxidative stress through PI3K/Akt signaling pathway in DSS-induced ulcerative colitis mice
by: Shuguang Yan, et al.
Published: (2020-09-01)

miR‐330 alleviates dextran sodium sulfate‐induced ulcerative colitis through targeting IRAK1 in rats
by: Qing Zhang, et al.
Published: (2021-06-01)

Coumarin Derivative N6 as a Novel anti-hantavirus Infection Agent Targeting AKT
by: Zhoupeng Li, et al.
Published: (2021-12-01)

PI3K inhibitors in thrombosis and cardiovascular disease
by: Tom N. Durrant, et al.
Published: (2020-01-01)

Icariin protects against sodium azide—induced neurotoxicity by activating the PI3K/Akt/GSK-3β signaling pathway
by: Ying Zhang, et al.
Published: (2020-04-01)

Anticancer Effect of Fucoidan on DU-145 Prostate Cancer Cells through Inhibition of PI3K/Akt and MAPK Pathway Expression
by: Gang-Sik Choo, et al.
Published: (2016-07-01)

Profile of Tofacitinib in the Treatment of Ulcerative Colitis: An Evidence-Based Review of Recent Data
by: Varyani F, et al.
Published: (2019-12-01)

Gaudichaudione H Inhibits Inflammatory Responses in Macrophages and Dextran Sodium Sulfate-Induced Colitis in Mice
by: Yiwen Jiang, et al.
Published: (2020-01-01)

Circadian Clock Protein PERIOD2 Suppresses the PI3K/Akt Pathway and Promotes Cisplatin Sensitivity in Ovarian Cancer
by: Wang Z, et al.
Published: (2020-11-01)

Phosphoinositide Signaling in Immune Cell Migration
by: Ruchi Kakar, et al.
Published: (2023-11-01)

Transmembrane protein 176B regulates amino acid metabolism through the PI3K-Akt-mTOR signaling pathway and promotes gastric cancer progression
by: Jing Li, et al.
Published: (2024-03-01)

Graphene oxide exacerbates dextran sodium sulfate-induced colitis via ROS/AMPK/p53 signaling to mediate apoptosis
by: Siliang Liu, et al.
Published: (2021-03-01)

Delivery of Active AKT1 to Human Cells
by: Tarana Siddika, et al.
Published: (2022-11-01)

Protective effect and mechanism of resveratrol on optic nerve injury in glaucoma rats
by: Lin He, et al.
Published: (2021-01-01)

Effect of CHKA gene silencing on biological behavior of glioma cell and its mechanism
by: HUANG Ling , ZOU Yourui , LI Zuoqi , MA Yue , GAO Xinyi , MA Hui
Published: (2021-11-01)

Improving Effect of Ligustilide on Dextran Sodium Sulfate-induced Ulcerative Colitis
by: Guangli MA, et al.
Published: (2024-02-01)

Effect of hydrogen-rich water on brain injury in rats with acute radiation based on PI3K/AKT/Caspase-9 signaling pathway
by: Yong WANG, et al.
Published: (2023-03-01)

Phosphoinositide 3-Kinase Signaling in the Tumor Microenvironment: What Do We Need to Consider When Treating Chronic Lymphocytic Leukemia With PI3K Inhibitors?
by: Ebru Aydin, et al.
Published: (2021-01-01)

Administration of Akkermansia muciniphila Ameliorates Dextran Sulfate Sodium-Induced Ulcerative Colitis in Mice
by: Xiaoyuan Bian, et al.
Published: (2019-10-01)

Activated PI3 Kinase Delta Syndrome: From Genetics to Therapy
by: David Michalovich, et al.
Published: (2018-02-01)

Atopic Dermatitis and Ulcerative Colitis Successfully Treated with Upadacitinib
by: Teresa Grieco, et al.
Published: (2023-03-01)

ATF5 promotes malignant T cell survival through the PI3K/AKT/mTOR pathway in cutaneous T cell lymphoma
by: Mengzhou Cao, et al.
Published: (2023-12-01)

Gochujang, a traditional Korean fermented food, protects through suppressed inflammatory pathways and histological structure disruption in dextran sodium sulfate (DSS)-induced colitis mice
by: Hak Yong Lee, et al.
Published: (2024-03-01)

Calcium-Prolactin Secretion Coupling in Rat Pituitary Lactotrophs Is Controlled by PI4-Kinase Alpha
by: Marek Kučka, et al.
Published: (2021-12-01)

PI3K/Akt/mTOR inhibitors in breast cancer
by: Joycelyn JX Lee, et al.
Published: (2015-12-01)

Editorial for the Research Topic "Targeting PI3K/mTOR signaling in cancer"
by: Alexandre eArcaro
Published: (2014-04-01)

Dihydrotestosterone induces SREBP-1 expression and lipogenesis through the phosphoinositide 3-kinase/Akt pathway in HaCaT cells
by: Zhou Bing-rong, et al.
Published: (2012-11-01)

Critical Appraisal of Filgotinib in the Treatment of Ulcerative Colitis: Current Evidence and Place in Therapy
by: Dal Buono A, et al.
Published: (2022-07-01)

The Role of Primary Cilia-Associated Phosphoinositide Signaling in Development
by: Chuan Chen, et al.
Published: (2022-12-01)

Phosphatidylinositol Kinases and Phosphatases in Entamoeba histolytica
by: Kumiko Nakada-Tsukui, et al.
Published: (2019-06-01)

Evaluation of Lymphoproliferative Disease and Increased Risk of Lymphoma in Activated Phosphoinositide 3 Kinase Delta Syndrome: A Case Report With Discussion
by: Michele N. Pham, et al.
Published: (2018-12-01)

Tofacitinib induction and maintenance therapy in East Asian patients with active ulcerative colitis: subgroup analyses from three phase 3 multinational studies
by: Satoshi Motoya, et al.
Published: (2018-04-01)

Inhibition of Notch Signaling Promotes the Adipogenic Differentiation of Mesenchymal Stem Cells Through Autophagy Activation and PTEN-PI3K/AKT/mTOR Pathway
by: Bao-quan Song, et al.
Published: (2015-07-01)

Targeted Sequencing of Cytokine-Induced PI3K-Related Genes in Ulcerative Colitis, Colorectal Cancer and Colitis-Associated Cancer
by: Nurul Nadirah Razali, et al.
Published: (2022-09-01)

A Case of Lung Abscess Caused by Double Immunosuppressive Therapy to Treat Ulcerative Colitis
by: Keiichi Tominaga, et al.
Published: (2020-11-01)

MLH1 Deficiency Induces Cetuximab Resistance in Colon Cancer via Her‐2/PI3K/AKT Signaling
by: Ying Han, et al.
Published: (2020-07-01)