Acute Respiratory Distress Syndrome: Focus on Viral Origin and Role of Pulmonary Lymphatics
Acute respiratory distress syndrome (ARDS) is a serious affection of the lung caused by a variety of pathologies. Great interest is currently focused on ARDS induced by viruses (pandemic influenza and corona viruses). The review describes pulmonary changes in ARDS and specific effects of the pandemi...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-11-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/9/11/1732 |
| _version_ | 1797511046347358208 |
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| author | Eleonore Fröhlich |
| author_facet | Eleonore Fröhlich |
| author_sort | Eleonore Fröhlich |
| collection | DOAJ |
| description | Acute respiratory distress syndrome (ARDS) is a serious affection of the lung caused by a variety of pathologies. Great interest is currently focused on ARDS induced by viruses (pandemic influenza and corona viruses). The review describes pulmonary changes in ARDS and specific effects of the pandemic viruses in ARDS, and summarizes treatment options. Because the known pathogenic mechanisms cannot explain all aspects of the syndrome, the contribution of pulmonary lymphatics to the pathology is discussed. Organization and function of lymphatics in a healthy lung and in resorption of pulmonary edema are described. A future clinical trial may provide more insight into the role of hyaluronan in ARDS but the development of promising pharmacological treatments is unlikely because drugs play no important role in lymphedema therapy. |
| first_indexed | 2024-03-10T05:40:51Z |
| format | Article |
| id | doaj.art-00caf7fd858342efb3c23124f2f0d889 |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-10T05:40:51Z |
| publishDate | 2021-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-00caf7fd858342efb3c23124f2f0d8892023-11-22T22:32:38ZengMDPI AGBiomedicines2227-90592021-11-01911173210.3390/biomedicines9111732Acute Respiratory Distress Syndrome: Focus on Viral Origin and Role of Pulmonary LymphaticsEleonore Fröhlich0Center for Medical Research, Medical University of Graz, 8010 Graz, AustriaAcute respiratory distress syndrome (ARDS) is a serious affection of the lung caused by a variety of pathologies. Great interest is currently focused on ARDS induced by viruses (pandemic influenza and corona viruses). The review describes pulmonary changes in ARDS and specific effects of the pandemic viruses in ARDS, and summarizes treatment options. Because the known pathogenic mechanisms cannot explain all aspects of the syndrome, the contribution of pulmonary lymphatics to the pathology is discussed. Organization and function of lymphatics in a healthy lung and in resorption of pulmonary edema are described. A future clinical trial may provide more insight into the role of hyaluronan in ARDS but the development of promising pharmacological treatments is unlikely because drugs play no important role in lymphedema therapy.https://www.mdpi.com/2227-9059/9/11/1732acute respiratory distress syndromepulmonary lymphaticsinfluenza viruscorona viruspulmonary edemaacute respiratory distress syndrome (ARDS) treatment |
| spellingShingle | Eleonore Fröhlich Acute Respiratory Distress Syndrome: Focus on Viral Origin and Role of Pulmonary Lymphatics Biomedicines acute respiratory distress syndrome pulmonary lymphatics influenza virus corona virus pulmonary edema acute respiratory distress syndrome (ARDS) treatment |
| title | Acute Respiratory Distress Syndrome: Focus on Viral Origin and Role of Pulmonary Lymphatics |
| title_full | Acute Respiratory Distress Syndrome: Focus on Viral Origin and Role of Pulmonary Lymphatics |
| title_fullStr | Acute Respiratory Distress Syndrome: Focus on Viral Origin and Role of Pulmonary Lymphatics |
| title_full_unstemmed | Acute Respiratory Distress Syndrome: Focus on Viral Origin and Role of Pulmonary Lymphatics |
| title_short | Acute Respiratory Distress Syndrome: Focus on Viral Origin and Role of Pulmonary Lymphatics |
| title_sort | acute respiratory distress syndrome focus on viral origin and role of pulmonary lymphatics |
| topic | acute respiratory distress syndrome pulmonary lymphatics influenza virus corona virus pulmonary edema acute respiratory distress syndrome (ARDS) treatment |
| url | https://www.mdpi.com/2227-9059/9/11/1732 |
| work_keys_str_mv | AT eleonorefrohlich acuterespiratorydistresssyndromefocusonviraloriginandroleofpulmonarylymphatics |