Illuminating the Anticancerous Efficacy of a New Fungal Chassis for Silver Nanoparticle Synthesis
Biogenic silver nanoparticles (Ag NPs) have supple platforms designed for biomedical and therapeutic intervention. Utilization of Ag NPs are preferred in the field of biomedicines and material science research because of their antioxidant, antimicrobial, and anticancerous activity along with their e...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2019-02-01
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| Series: | Frontiers in Chemistry |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fchem.2019.00065/full |
| _version_ | 1828520044247646208 |
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| author | Nafe Aziz Mohd Faraz Mohd Asif Sherwani Tasneem Fatma Ram Prasad Ram Prasad |
| author_facet | Nafe Aziz Mohd Faraz Mohd Asif Sherwani Tasneem Fatma Ram Prasad Ram Prasad |
| author_sort | Nafe Aziz |
| collection | DOAJ |
| description | Biogenic silver nanoparticles (Ag NPs) have supple platforms designed for biomedical and therapeutic intervention. Utilization of Ag NPs are preferred in the field of biomedicines and material science research because of their antioxidant, antimicrobial, and anticancerous activity along with their eco-friendly, biocompatible, and cost-effective nature. Here we present a novel fungus Piriformospora indica as an excellent source for obtaining facile and reliable Ag NPs with a high degree of consistent morphology. We demonstrated their cytotoxic property, coupled with their intrinsic characteristic that make these biogenic nanoparticles suitable for the anticancerous activity. In vitro cytotoxicity of biologically synthesized Ag NPs (BSNPs) and chemically synthesized Ag NPs (SNPs) was screened on various cancer cell lines, such as Human breast adenocarcinoma (MCF-7), Human cervical carcinoma (HeLa), Human liver hepatocellular carcinoma (HepG2) cell lines and embryonic kidney cell line (HEK-293) as normal cell lines. The antiproliferative outcome revealed that the BSNPs exhibited significant cytotoxic activity against MCF-7 followed by HeLa and HepG2 cell lines as compared to SNPs. The blend of cytotoxic properties, together with green and cost-effective characteristics make up these biogenic nanoparticles for their potential applications in cancer nanomedicine and fabrication coating of ambulatory and non-ambulatory medical devices. |
| first_indexed | 2024-12-11T19:23:54Z |
| format | Article |
| id | doaj.art-00cc5a8189284f83a896faa4fdd57ba4 |
| institution | Directory Open Access Journal |
| issn | 2296-2646 |
| language | English |
| last_indexed | 2024-12-11T19:23:54Z |
| publishDate | 2019-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Chemistry |
| spelling | doaj.art-00cc5a8189284f83a896faa4fdd57ba42022-12-22T00:53:27ZengFrontiers Media S.A.Frontiers in Chemistry2296-26462019-02-01710.3389/fchem.2019.00065422325Illuminating the Anticancerous Efficacy of a New Fungal Chassis for Silver Nanoparticle SynthesisNafe Aziz0Mohd Faraz1Mohd Asif Sherwani2Tasneem Fatma3Ram Prasad4Ram Prasad5Department of Biosciences, Jamia Millia Islamia, New Delhi, IndiaDepartment of Physics, Indian Institute of Technology Delhi, Haus Khas, New Delhi, IndiaInterdisciplinary Biotechnology Unit, Aligarh Muslim University, Aligarh, IndiaDepartment of Biosciences, Jamia Millia Islamia, New Delhi, IndiaSchool of Environmental Science and Engineering, Sun Yat-Sen University, Guangzhou, ChinaAmity Institute of Microbial Technology, Amity University, Noida, IndiaBiogenic silver nanoparticles (Ag NPs) have supple platforms designed for biomedical and therapeutic intervention. Utilization of Ag NPs are preferred in the field of biomedicines and material science research because of their antioxidant, antimicrobial, and anticancerous activity along with their eco-friendly, biocompatible, and cost-effective nature. Here we present a novel fungus Piriformospora indica as an excellent source for obtaining facile and reliable Ag NPs with a high degree of consistent morphology. We demonstrated their cytotoxic property, coupled with their intrinsic characteristic that make these biogenic nanoparticles suitable for the anticancerous activity. In vitro cytotoxicity of biologically synthesized Ag NPs (BSNPs) and chemically synthesized Ag NPs (SNPs) was screened on various cancer cell lines, such as Human breast adenocarcinoma (MCF-7), Human cervical carcinoma (HeLa), Human liver hepatocellular carcinoma (HepG2) cell lines and embryonic kidney cell line (HEK-293) as normal cell lines. The antiproliferative outcome revealed that the BSNPs exhibited significant cytotoxic activity against MCF-7 followed by HeLa and HepG2 cell lines as compared to SNPs. The blend of cytotoxic properties, together with green and cost-effective characteristics make up these biogenic nanoparticles for their potential applications in cancer nanomedicine and fabrication coating of ambulatory and non-ambulatory medical devices.https://www.frontiersin.org/article/10.3389/fchem.2019.00065/fullsilver nanoparticlesPiriformospora indicacancer cell lines (MCF-7, HeLa, HepG2)HEK-293cytotoxic activityantioxidant activity |
| spellingShingle | Nafe Aziz Mohd Faraz Mohd Asif Sherwani Tasneem Fatma Ram Prasad Ram Prasad Illuminating the Anticancerous Efficacy of a New Fungal Chassis for Silver Nanoparticle Synthesis Frontiers in Chemistry silver nanoparticles Piriformospora indica cancer cell lines (MCF-7, HeLa, HepG2) HEK-293 cytotoxic activity antioxidant activity |
| title | Illuminating the Anticancerous Efficacy of a New Fungal Chassis for Silver Nanoparticle Synthesis |
| title_full | Illuminating the Anticancerous Efficacy of a New Fungal Chassis for Silver Nanoparticle Synthesis |
| title_fullStr | Illuminating the Anticancerous Efficacy of a New Fungal Chassis for Silver Nanoparticle Synthesis |
| title_full_unstemmed | Illuminating the Anticancerous Efficacy of a New Fungal Chassis for Silver Nanoparticle Synthesis |
| title_short | Illuminating the Anticancerous Efficacy of a New Fungal Chassis for Silver Nanoparticle Synthesis |
| title_sort | illuminating the anticancerous efficacy of a new fungal chassis for silver nanoparticle synthesis |
| topic | silver nanoparticles Piriformospora indica cancer cell lines (MCF-7, HeLa, HepG2) HEK-293 cytotoxic activity antioxidant activity |
| url | https://www.frontiersin.org/article/10.3389/fchem.2019.00065/full |
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