Combining WGCNA and machine learning to construct basement membrane-related gene index helps to predict the prognosis and tumor microenvironment of HCC patients and verifies the carcinogenesis of key gene CTSA

Combining WGCNA and machine learning to construct basement membrane-related gene index helps to predict the prognosis and tumor microenvironment of HCC patients and verifies the carcinogenesis of key gene CTSA

Hepatocellular carcinoma (HCC) is a malignant tumor with high recurrence and metastasis rates and poor prognosis. Basement membrane is a ubiquitous extracellular matrix and is a key physical factor in cancer metastasis. Therefore, basement membrane-related genes may be new targets for the diagnosis...

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Bibliographic Details
Main Authors: Weijie Sun, Jue Wang, Zhiqiang Wang, Ming Xu, Quanjun Lin, Peng Sun, Yihang Yuan
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-05-01
Series:Frontiers in Immunology
Subjects:
hepatocellular carcinoma
basement membranes
prognosis
immunotherapy
machine learning
ScRNA-seq
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1185916/full

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