Propensity-Score Analysis Reveals that Sex is Not a Prognostic Factor for Mortality in Intensive Care Unit-Admitted Patients with Septic Bacteremia
ABSTRACT: Objective: Men have been considered to have a higher incidence of infectious diseases, with controversy over the possibility that sex could influence the prognosis of the infection. This study aimed to explore this assumption in patients admitted to the intensive care unit (ICU) with sept...
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| Format: | Article |
| Language: | English |
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Elsevier
2021-09-01
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| Series: | International Journal of Infectious Diseases |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1201971221005907 |
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| author | Manuel Ponce-Alonso Borja M. Fernández-Félix Ana Halperin Mario Rodríguez-Domínguez Ana M. Sánchez-Díaz Rafael Cantón Alfonso Muriel Javier Zamora Rosa del Campo |
| author_facet | Manuel Ponce-Alonso Borja M. Fernández-Félix Ana Halperin Mario Rodríguez-Domínguez Ana M. Sánchez-Díaz Rafael Cantón Alfonso Muriel Javier Zamora Rosa del Campo |
| author_sort | Manuel Ponce-Alonso |
| collection | DOAJ |
| description | ABSTRACT: Objective: Men have been considered to have a higher incidence of infectious diseases, with controversy over the possibility that sex could influence the prognosis of the infection. This study aimed to explore this assumption in patients admitted to the intensive care unit (ICU) with septic bacteremia. Methods: A retrospective analysis (2006-2017) of septic patients with microbiologically confirmed bacteremia (n=440) was performed. Risk of ICU and in-hospital mortality in males versus females was compared by univariate analysis and a propensity score analysis integrating their clinical characteristics. Results: Sepsis more frequently occurred in males (80.2% vs 76.1%) as well as in-hospital (48.0% vs 41.3%) and ICU (39.9% vs 36.5%) mortality. Univariate analyses showed that males had a higher Charlson comorbidity index and worse McCabe prognostic score. However, the propensity score in 296 matched patients demonstrated that females had higher risk of both ICU (OR 1.39; 95% CI 0.89-2.19) and in-hospital mortality (OR 1.18; 95% CI 0.77-1.83), but without statistical significance. Conclusion: Males with sepsis had worse clinical characteristics when admitted to the ICU, but sex had no influence on mortality. These data contribute to helping reduce the sex-dependent gap present in healthcare provision. |
| first_indexed | 2024-12-22T10:54:45Z |
| format | Article |
| id | doaj.art-00cd7c9b479f47f1b357d6865b905848 |
| institution | Directory Open Access Journal |
| issn | 1201-9712 |
| language | English |
| last_indexed | 2024-12-22T10:54:45Z |
| publishDate | 2021-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | International Journal of Infectious Diseases |
| spelling | doaj.art-00cd7c9b479f47f1b357d6865b9058482022-12-21T18:28:38ZengElsevierInternational Journal of Infectious Diseases1201-97122021-09-011103644Propensity-Score Analysis Reveals that Sex is Not a Prognostic Factor for Mortality in Intensive Care Unit-Admitted Patients with Septic BacteremiaManuel Ponce-Alonso0Borja M. Fernández-Félix1Ana Halperin2Mario Rodríguez-Domínguez3Ana M. Sánchez-Díaz4Rafael Cantón5Alfonso Muriel6Javier Zamora7Rosa del Campo8Servicio de Microbiología, Hospital Universitario Ramón y Cajal, Madrid, Spain; Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), Madrid, Spain; Red Española de Investigación en Patología Infecciosa (REIPI), Madrid, SpainInstituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), Madrid, Spain; Unidad de Bioestadística Clínica, Hospital Ramón y Cajal, Madrid, Spain; CIBER Epidemiology and Public Health (CIBERESP), Madrid, SpainServicio de Microbiología, Hospital Universitario Ramón y Cajal, Madrid, Spain; Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), Madrid, Spain; Red Española de Investigación en Patología Infecciosa (REIPI), Madrid, SpainServicio de Microbiología, Hospital Universitario Ramón y Cajal, Madrid, Spain; Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), Madrid, Spain; CIBER Epidemiology and Public Health (CIBERESP), Madrid, SpainServicio de Microbiología, Hospital Universitario Ramón y Cajal, Madrid, Spain; Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), Madrid, Spain; Red Española de Investigación en Patología Infecciosa (REIPI), Madrid, SpainServicio de Microbiología, Hospital Universitario Ramón y Cajal, Madrid, Spain; Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), Madrid, Spain; Red Española de Investigación en Patología Infecciosa (REIPI), Madrid, SpainInstituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), Madrid, Spain; Unidad de Bioestadística Clínica, Hospital Ramón y Cajal, Madrid, Spain; CIBER Epidemiology and Public Health (CIBERESP), Madrid, SpainInstituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), Madrid, Spain; Unidad de Bioestadística Clínica, Hospital Ramón y Cajal, Madrid, Spain; CIBER Epidemiology and Public Health (CIBERESP), Madrid, Spain; Institute of Metabolism and Systems Research, University of Birmingham, Birmingham, United Kingdom; Corresponding authors: Unidad de Bioestadística and Servicio de Microbiología, Hospital Universitario Ramón y Cajal, Ctra. Colmenar, Km 9,1. 28034 Madrid, Spain.Servicio de Microbiología, Hospital Universitario Ramón y Cajal, Madrid, Spain; Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), Madrid, Spain; Red Española de Investigación en Patología Infecciosa (REIPI), Madrid, Spain; University Alfonso X El Sabio, Villanueva de la Cañada, Madrid, Spain; Corresponding authors: Unidad de Bioestadística and Servicio de Microbiología, Hospital Universitario Ramón y Cajal, Ctra. Colmenar, Km 9,1. 28034 Madrid, Spain.ABSTRACT: Objective: Men have been considered to have a higher incidence of infectious diseases, with controversy over the possibility that sex could influence the prognosis of the infection. This study aimed to explore this assumption in patients admitted to the intensive care unit (ICU) with septic bacteremia. Methods: A retrospective analysis (2006-2017) of septic patients with microbiologically confirmed bacteremia (n=440) was performed. Risk of ICU and in-hospital mortality in males versus females was compared by univariate analysis and a propensity score analysis integrating their clinical characteristics. Results: Sepsis more frequently occurred in males (80.2% vs 76.1%) as well as in-hospital (48.0% vs 41.3%) and ICU (39.9% vs 36.5%) mortality. Univariate analyses showed that males had a higher Charlson comorbidity index and worse McCabe prognostic score. However, the propensity score in 296 matched patients demonstrated that females had higher risk of both ICU (OR 1.39; 95% CI 0.89-2.19) and in-hospital mortality (OR 1.18; 95% CI 0.77-1.83), but without statistical significance. Conclusion: Males with sepsis had worse clinical characteristics when admitted to the ICU, but sex had no influence on mortality. These data contribute to helping reduce the sex-dependent gap present in healthcare provision.http://www.sciencedirect.com/science/article/pii/S1201971221005907SexICUSepsisMortalityPropensity score |
| spellingShingle | Manuel Ponce-Alonso Borja M. Fernández-Félix Ana Halperin Mario Rodríguez-Domínguez Ana M. Sánchez-Díaz Rafael Cantón Alfonso Muriel Javier Zamora Rosa del Campo Propensity-Score Analysis Reveals that Sex is Not a Prognostic Factor for Mortality in Intensive Care Unit-Admitted Patients with Septic Bacteremia International Journal of Infectious Diseases Sex ICU Sepsis Mortality Propensity score |
| title | Propensity-Score Analysis Reveals that Sex is Not a Prognostic Factor for Mortality in Intensive Care Unit-Admitted Patients with Septic Bacteremia |
| title_full | Propensity-Score Analysis Reveals that Sex is Not a Prognostic Factor for Mortality in Intensive Care Unit-Admitted Patients with Septic Bacteremia |
| title_fullStr | Propensity-Score Analysis Reveals that Sex is Not a Prognostic Factor for Mortality in Intensive Care Unit-Admitted Patients with Septic Bacteremia |
| title_full_unstemmed | Propensity-Score Analysis Reveals that Sex is Not a Prognostic Factor for Mortality in Intensive Care Unit-Admitted Patients with Septic Bacteremia |
| title_short | Propensity-Score Analysis Reveals that Sex is Not a Prognostic Factor for Mortality in Intensive Care Unit-Admitted Patients with Septic Bacteremia |
| title_sort | propensity score analysis reveals that sex is not a prognostic factor for mortality in intensive care unit admitted patients with septic bacteremia |
| topic | Sex ICU Sepsis Mortality Propensity score |
| url | http://www.sciencedirect.com/science/article/pii/S1201971221005907 |
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