Effects of beta-alanine supplementation on body composition: a GRADE-assessed systematic review and meta-analysis
Purpose Previous studies have suggested that beta-alanine supplementation may benefit exercise performance, but current evidence regarding its effects on body composition remains unclear. This systematic review and meta-analysis aimed to investigate the effects of beta-alanine supplementation on bod...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2022-12-01
|
| Series: | Journal of the International Society of Sports Nutrition |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/15502783.2022.2079384 |
| _version_ | 1827811680997867520 |
|---|---|
| author | Damoon Ashtary-Larky Reza Bagheri Matin Ghanavati Omid Asbaghi Alexei Wong Jeffrey R. Stout Katsuhiko Suzuki |
| author_facet | Damoon Ashtary-Larky Reza Bagheri Matin Ghanavati Omid Asbaghi Alexei Wong Jeffrey R. Stout Katsuhiko Suzuki |
| author_sort | Damoon Ashtary-Larky |
| collection | DOAJ |
| description | Purpose Previous studies have suggested that beta-alanine supplementation may benefit exercise performance, but current evidence regarding its effects on body composition remains unclear. This systematic review and meta-analysis aimed to investigate the effects of beta-alanine supplementation on body composition indices. Methods Online databases, including PubMed/Medline, Scopus, Web of Science, and Embase, were searched up to April 2021 to retrieve randomized controlled trials (RCTs), which examined the effect of beta-alanine supplementation on body composition indices. Meta-analyses were carried out using a random-effects model. The I2 index was used to assess the heterogeneity of RCTs. Results Among the initial 1413 studies that were identified from electronic databases search, 20 studies involving 492 participants were eligible. Pooled effect size from 20 studies indicated that beta-alanine supplementation has no effect on body mass (WMD: −0.15 kg; 95% CI: −0.78 to 0.47; p = 0.631, I2 = 0.0%, p = 0.998), fat mass (FM) (WMD: −0.24 kg; 95% CI: −1.16 to 0.68; p = 0.612, I2 = 0.0%, p = 0.969), body fat percentage (BFP) (WMD: −0.06%; 95% CI: −0.53 to 0.40; p = 0.782, I2 = 0.0%, p = 0.936), and fat-free mass (FFM) (WMD: 0.05 kg; 95% CI: −0.71 to 0.82; p = 0.889, I2 = 0.0%, p = 0.912). Subgroup analyses based on exercise type (resistance training [RT], endurance training [ET], and combined training [CT]), study duration (<8 and ≥8 weeks), and beta-alanine dosage (<6 and ≥6 g/d) demonstrated similar results. Certainty of evidence across outcomes ranged from low to moderate. Conclusions This meta-analysis study suggests that beta-alanine supplementation is unlikely to improve body composition indices regardless of supplementation dosage and its combination with exercise training. No studies have examined the effect of beta-alanine combined with both diet and exercise on body composition changes as the primary variable. Therefore, future studies examining the effect of the combination of beta-alanine supplementation with a hypocaloric diet and exercise programs are warranted. |
| first_indexed | 2024-03-11T23:08:01Z |
| format | Article |
| id | doaj.art-00d0569c73654998aebeba9519ef66f1 |
| institution | Directory Open Access Journal |
| issn | 1550-2783 |
| language | English |
| last_indexed | 2024-03-11T23:08:01Z |
| publishDate | 2022-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Journal of the International Society of Sports Nutrition |
| spelling | doaj.art-00d0569c73654998aebeba9519ef66f12023-09-21T12:43:10ZengTaylor & Francis GroupJournal of the International Society of Sports Nutrition1550-27832022-12-0119119621810.1080/15502783.2022.20793842079384Effects of beta-alanine supplementation on body composition: a GRADE-assessed systematic review and meta-analysisDamoon Ashtary-Larky0Reza Bagheri1Matin Ghanavati2Omid Asbaghi3Alexei Wong4Jeffrey R. Stout5Katsuhiko Suzuki6Ahvaz Jundishapur University of Medical SciencesUniversity of IsfahanShahid Beheshti University of Medical SciencesShahid Beheshti University of Medical SciencesMarymount UniversityUniversity of Central FloridaWaseda UniversityPurpose Previous studies have suggested that beta-alanine supplementation may benefit exercise performance, but current evidence regarding its effects on body composition remains unclear. This systematic review and meta-analysis aimed to investigate the effects of beta-alanine supplementation on body composition indices. Methods Online databases, including PubMed/Medline, Scopus, Web of Science, and Embase, were searched up to April 2021 to retrieve randomized controlled trials (RCTs), which examined the effect of beta-alanine supplementation on body composition indices. Meta-analyses were carried out using a random-effects model. The I2 index was used to assess the heterogeneity of RCTs. Results Among the initial 1413 studies that were identified from electronic databases search, 20 studies involving 492 participants were eligible. Pooled effect size from 20 studies indicated that beta-alanine supplementation has no effect on body mass (WMD: −0.15 kg; 95% CI: −0.78 to 0.47; p = 0.631, I2 = 0.0%, p = 0.998), fat mass (FM) (WMD: −0.24 kg; 95% CI: −1.16 to 0.68; p = 0.612, I2 = 0.0%, p = 0.969), body fat percentage (BFP) (WMD: −0.06%; 95% CI: −0.53 to 0.40; p = 0.782, I2 = 0.0%, p = 0.936), and fat-free mass (FFM) (WMD: 0.05 kg; 95% CI: −0.71 to 0.82; p = 0.889, I2 = 0.0%, p = 0.912). Subgroup analyses based on exercise type (resistance training [RT], endurance training [ET], and combined training [CT]), study duration (<8 and ≥8 weeks), and beta-alanine dosage (<6 and ≥6 g/d) demonstrated similar results. Certainty of evidence across outcomes ranged from low to moderate. Conclusions This meta-analysis study suggests that beta-alanine supplementation is unlikely to improve body composition indices regardless of supplementation dosage and its combination with exercise training. No studies have examined the effect of beta-alanine combined with both diet and exercise on body composition changes as the primary variable. Therefore, future studies examining the effect of the combination of beta-alanine supplementation with a hypocaloric diet and exercise programs are warranted.http://dx.doi.org/10.1080/15502783.2022.2079384beta-alaninebody compositionmeta-analysissystematic review |
| spellingShingle | Damoon Ashtary-Larky Reza Bagheri Matin Ghanavati Omid Asbaghi Alexei Wong Jeffrey R. Stout Katsuhiko Suzuki Effects of beta-alanine supplementation on body composition: a GRADE-assessed systematic review and meta-analysis Journal of the International Society of Sports Nutrition beta-alanine body composition meta-analysis systematic review |
| title | Effects of beta-alanine supplementation on body composition: a GRADE-assessed systematic review and meta-analysis |
| title_full | Effects of beta-alanine supplementation on body composition: a GRADE-assessed systematic review and meta-analysis |
| title_fullStr | Effects of beta-alanine supplementation on body composition: a GRADE-assessed systematic review and meta-analysis |
| title_full_unstemmed | Effects of beta-alanine supplementation on body composition: a GRADE-assessed systematic review and meta-analysis |
| title_short | Effects of beta-alanine supplementation on body composition: a GRADE-assessed systematic review and meta-analysis |
| title_sort | effects of beta alanine supplementation on body composition a grade assessed systematic review and meta analysis |
| topic | beta-alanine body composition meta-analysis systematic review |
| url | http://dx.doi.org/10.1080/15502783.2022.2079384 |
| work_keys_str_mv | AT damoonashtarylarky effectsofbetaalaninesupplementationonbodycompositionagradeassessedsystematicreviewandmetaanalysis AT rezabagheri effectsofbetaalaninesupplementationonbodycompositionagradeassessedsystematicreviewandmetaanalysis AT matinghanavati effectsofbetaalaninesupplementationonbodycompositionagradeassessedsystematicreviewandmetaanalysis AT omidasbaghi effectsofbetaalaninesupplementationonbodycompositionagradeassessedsystematicreviewandmetaanalysis AT alexeiwong effectsofbetaalaninesupplementationonbodycompositionagradeassessedsystematicreviewandmetaanalysis AT jeffreyrstout effectsofbetaalaninesupplementationonbodycompositionagradeassessedsystematicreviewandmetaanalysis AT katsuhikosuzuki effectsofbetaalaninesupplementationonbodycompositionagradeassessedsystematicreviewandmetaanalysis |