The role of macrophage migration inhibitory factor in obesity-associated type 2 diabetes in mice
Macrophage migration inhibitory factor (MIF) is implicated in the pathogenesis of several inflammationrelated diseases, including obesity and type 2 diabetes (T2D). However, MIF deficiency itself promotes obesity and glucose intolerance in mice. Here we show that the introduction of a high-fat d...
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| Format: | Article |
| Language: | English |
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University of Belgrade, University of Novi Sad
2013-01-01
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| Series: | Archives of Biological Sciences |
| Subjects: | |
| Online Access: | http://www.doiserbia.nb.rs/img/doi/0354-4664/2013/0354-46641302499S.pdf |
| _version_ | 1819260022444523520 |
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| author | Saksida Tamara Stošić-Grujičić Stanislava Stojanović Ivana |
| author_facet | Saksida Tamara Stošić-Grujičić Stanislava Stojanović Ivana |
| author_sort | Saksida Tamara |
| collection | DOAJ |
| description | Macrophage migration inhibitory factor (MIF) is implicated in the pathogenesis of several inflammationrelated diseases, including obesity and type 2 diabetes (T2D). However, MIF deficiency itself promotes obesity and glucose intolerance in mice. Here we show that the introduction of a high-fat diet (HFD) further aggravates the parameters of obesity-associated T2D: weight gain and glucose intolerance. Furthermore, in contrast to MIF-KO mice on standard chow, HFD-fed MIF-KO mice develop insulin resistance. Although the clinical signs of obesity-associated T2D are upgraded, inflammation in MIF-deficient mice on HFD is significantly lower. These results imply that MIF possesses a complex role in glucose metabolism and the development of obesity-related T2D. However, the downregulation of inflammation upon MIF inhibition could be a useful tool in short-term T2D therapy for preventing pancreatic islet deterioration. [Projekat Ministarstva nauke Republike Srbije, br. 173013] |
| first_indexed | 2024-12-23T19:19:18Z |
| format | Article |
| id | doaj.art-00d3426015cc43fe965577d4d85a7fce |
| institution | Directory Open Access Journal |
| issn | 0354-4664 1821-4339 |
| language | English |
| last_indexed | 2024-12-23T19:19:18Z |
| publishDate | 2013-01-01 |
| publisher | University of Belgrade, University of Novi Sad |
| record_format | Article |
| series | Archives of Biological Sciences |
| spelling | doaj.art-00d3426015cc43fe965577d4d85a7fce2022-12-21T17:34:13ZengUniversity of Belgrade, University of Novi SadArchives of Biological Sciences0354-46641821-43392013-01-0165249950510.2298/ABS1302499SThe role of macrophage migration inhibitory factor in obesity-associated type 2 diabetes in miceSaksida TamaraStošić-Grujičić StanislavaStojanović IvanaMacrophage migration inhibitory factor (MIF) is implicated in the pathogenesis of several inflammationrelated diseases, including obesity and type 2 diabetes (T2D). However, MIF deficiency itself promotes obesity and glucose intolerance in mice. Here we show that the introduction of a high-fat diet (HFD) further aggravates the parameters of obesity-associated T2D: weight gain and glucose intolerance. Furthermore, in contrast to MIF-KO mice on standard chow, HFD-fed MIF-KO mice develop insulin resistance. Although the clinical signs of obesity-associated T2D are upgraded, inflammation in MIF-deficient mice on HFD is significantly lower. These results imply that MIF possesses a complex role in glucose metabolism and the development of obesity-related T2D. However, the downregulation of inflammation upon MIF inhibition could be a useful tool in short-term T2D therapy for preventing pancreatic islet deterioration. [Projekat Ministarstva nauke Republike Srbije, br. 173013]http://www.doiserbia.nb.rs/img/doi/0354-4664/2013/0354-46641302499S.pdfmacrophage migration inhibitory factortype 2 diabetesobesityinflammation |
| spellingShingle | Saksida Tamara Stošić-Grujičić Stanislava Stojanović Ivana The role of macrophage migration inhibitory factor in obesity-associated type 2 diabetes in mice Archives of Biological Sciences macrophage migration inhibitory factor type 2 diabetes obesity inflammation |
| title | The role of macrophage migration inhibitory factor in obesity-associated type 2 diabetes in mice |
| title_full | The role of macrophage migration inhibitory factor in obesity-associated type 2 diabetes in mice |
| title_fullStr | The role of macrophage migration inhibitory factor in obesity-associated type 2 diabetes in mice |
| title_full_unstemmed | The role of macrophage migration inhibitory factor in obesity-associated type 2 diabetes in mice |
| title_short | The role of macrophage migration inhibitory factor in obesity-associated type 2 diabetes in mice |
| title_sort | role of macrophage migration inhibitory factor in obesity associated type 2 diabetes in mice |
| topic | macrophage migration inhibitory factor type 2 diabetes obesity inflammation |
| url | http://www.doiserbia.nb.rs/img/doi/0354-4664/2013/0354-46641302499S.pdf |
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