Three cases of bone metastases in patients with gastrointestinal stromal tumors
Gastrointestinal stromal tumors (GISTs) are rare, but represent the most common mesenchymal neoplasms of the gastrointestinal tract. Tumor resection is the treatment of choice for localized disease. Tyrosine kinase inhibitors (imatinib, sunitinib) are the standard therapy for metastatic or unresecta...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2011-04-01
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| Series: | Rare Tumors |
| Subjects: | |
| Online Access: | http://www.pagepress.org/journals/index.php/rt/article/view/2307 |
| _version_ | 1818838137216958464 |
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| author | Maurizio Zompatori Giorgio Garzillo Guido Biasco Maristella Saponara Cristian Lolli Anna Mandrioli Monica Di Battista Alberto Bazzocchi Margherita Nannini Alessandra Maleddu Laura Greco Maria Caterina Pallotti Maria Abbondanza Pantaleo Valerio Di Scioscio |
| author_facet | Maurizio Zompatori Giorgio Garzillo Guido Biasco Maristella Saponara Cristian Lolli Anna Mandrioli Monica Di Battista Alberto Bazzocchi Margherita Nannini Alessandra Maleddu Laura Greco Maria Caterina Pallotti Maria Abbondanza Pantaleo Valerio Di Scioscio |
| author_sort | Maurizio Zompatori |
| collection | DOAJ |
| description | Gastrointestinal stromal tumors (GISTs) are rare, but represent the most common mesenchymal neoplasms of the gastrointestinal tract. Tumor resection is the treatment of choice for localized disease. Tyrosine kinase inhibitors (imatinib, sunitinib) are the standard therapy for metastatic or unresectable GISTs. GISTs usually metastasize to the liver and peritoneum. Bone metastases are uncommon. We describe three cases of bone metastases in patients with advanced GISTs: two women (82 and 54 years of age), and one man (62 years of age). Bones metastases involved the spine, pelvis and ribs in one patient, multiple vertebral bodies and pelvis in one, and the spine and iliac wings in the third case. The lesions presented a lytic pattern in all cases. Two patients presented with multiple bone metastases at the time of initial diagnosis and one patient after seven years during the follow-up period. This report describes the diagnosis and treatment of the lesions and may help clinicians to manage bones metastases in GIST patients. |
| first_indexed | 2024-12-19T03:33:37Z |
| format | Article |
| id | doaj.art-00d57c71501347d79b74a1846e649069 |
| institution | Directory Open Access Journal |
| issn | 2036-3605 2036-3613 |
| language | English |
| last_indexed | 2024-12-19T03:33:37Z |
| publishDate | 2011-04-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Rare Tumors |
| spelling | doaj.art-00d57c71501347d79b74a1846e6490692022-12-21T20:37:27ZengSAGE PublishingRare Tumors2036-36052036-36132011-04-0132e17e1710.4081/rt.2011.e17Three cases of bone metastases in patients with gastrointestinal stromal tumorsMaurizio ZompatoriGiorgio GarzilloGuido BiascoMaristella SaponaraCristian LolliAnna MandrioliMonica Di BattistaAlberto BazzocchiMargherita NanniniAlessandra MaledduLaura GrecoMaria Caterina PallottiMaria Abbondanza PantaleoValerio Di ScioscioGastrointestinal stromal tumors (GISTs) are rare, but represent the most common mesenchymal neoplasms of the gastrointestinal tract. Tumor resection is the treatment of choice for localized disease. Tyrosine kinase inhibitors (imatinib, sunitinib) are the standard therapy for metastatic or unresectable GISTs. GISTs usually metastasize to the liver and peritoneum. Bone metastases are uncommon. We describe three cases of bone metastases in patients with advanced GISTs: two women (82 and 54 years of age), and one man (62 years of age). Bones metastases involved the spine, pelvis and ribs in one patient, multiple vertebral bodies and pelvis in one, and the spine and iliac wings in the third case. The lesions presented a lytic pattern in all cases. Two patients presented with multiple bone metastases at the time of initial diagnosis and one patient after seven years during the follow-up period. This report describes the diagnosis and treatment of the lesions and may help clinicians to manage bones metastases in GIST patients.http://www.pagepress.org/journals/index.php/rt/article/view/2307GISTs, CT scan, bone metastases, Imatinib |
| spellingShingle | Maurizio Zompatori Giorgio Garzillo Guido Biasco Maristella Saponara Cristian Lolli Anna Mandrioli Monica Di Battista Alberto Bazzocchi Margherita Nannini Alessandra Maleddu Laura Greco Maria Caterina Pallotti Maria Abbondanza Pantaleo Valerio Di Scioscio Three cases of bone metastases in patients with gastrointestinal stromal tumors Rare Tumors GISTs, CT scan, bone metastases, Imatinib |
| title | Three cases of bone metastases in patients with gastrointestinal stromal tumors |
| title_full | Three cases of bone metastases in patients with gastrointestinal stromal tumors |
| title_fullStr | Three cases of bone metastases in patients with gastrointestinal stromal tumors |
| title_full_unstemmed | Three cases of bone metastases in patients with gastrointestinal stromal tumors |
| title_short | Three cases of bone metastases in patients with gastrointestinal stromal tumors |
| title_sort | three cases of bone metastases in patients with gastrointestinal stromal tumors |
| topic | GISTs, CT scan, bone metastases, Imatinib |
| url | http://www.pagepress.org/journals/index.php/rt/article/view/2307 |
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