Reduced BMP signaling results in hindlimb fusion with lethal pelvic/urogenital organ aplasia: a new mouse model of sirenomelia.

Reduced BMP signaling results in hindlimb fusion with lethal pelvic/urogenital organ aplasia: a new mouse model of sirenomelia.

Sirenomelia, also known as mermaid syndrome, is a developmental malformation of the caudal body characterized by leg fusion and associated anomalies of pelvic/urogenital organs including bladder, kidney, rectum and external genitalia. Most affected infants are stillborn, and the few born alive rarel...

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Bibliographic Details
Main Authors: Kentaro Suzuki, Yasuha Adachi, Tomokazu Numata, Shoko Nakada, Motoko Yanagita, Naomi Nakagata, Sylvia M Evans, Daniel Graf, Aris Economides, Ryuma Haraguchi, Anne M Moon, Gen Yamada
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3444444?pdf=render

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http://europepmc.org/articles/PMC3444444?pdf=render

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