GLIS3 regulates transcription of thyroid hormone biosynthetic genes in coordination with other thyroid transcription factors

GLIS3 regulates transcription of thyroid hormone biosynthetic genes in coordination with other thyroid transcription factors

Abstract Background Loss of the transcription factor GLI-Similar 3 (GLIS3) function causes congenital hypothyroidism (CH) in both humans and mice due to decreased expression of several thyroid hormone (TH) biosynthetic genes in thyroid follicular cells. Whether and to what extent, GLIS3 regulates th...

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Bibliographische Detailangaben
Hauptverfasser: Hong Soon Kang, Sara A. Grimm, Raja Jothi, Pilar Santisteban, Anton M. Jetten
Format: Artikel
Sprache:English
Veröffentlicht: BMC 2023-02-01
Schriftenreihe:Cell & Bioscience
Schlagworte:
GLIS3
NKX2.1
PAX8
FOXE1
Gene transcription
Thyroid follicular cells
Online Zugang:https://doi.org/10.1186/s13578-023-00979-8

Online

https://doi.org/10.1186/s13578-023-00979-8

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