GLIS3 regulates transcription of thyroid hormone biosynthetic genes in coordination with other thyroid transcription factors

GLIS3 regulates transcription of thyroid hormone biosynthetic genes in coordination with other thyroid transcription factors

Abstract Background Loss of the transcription factor GLI-Similar 3 (GLIS3) function causes congenital hypothyroidism (CH) in both humans and mice due to decreased expression of several thyroid hormone (TH) biosynthetic genes in thyroid follicular cells. Whether and to what extent, GLIS3 regulates th...

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Bibliografske podrobnosti
Main Authors: Hong Soon Kang, Sara A. Grimm, Raja Jothi, Pilar Santisteban, Anton M. Jetten
Format: Article
Jezik:English
Izdano: BMC 2023-02-01
Serija:Cell & Bioscience
Teme:
GLIS3
NKX2.1
PAX8
FOXE1
Gene transcription
Thyroid follicular cells
Online dostop:https://doi.org/10.1186/s13578-023-00979-8

Internet

https://doi.org/10.1186/s13578-023-00979-8

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