Post-mortem neuropathologic examination of a 6-case series of CAR T-cell treated patients

Post-mortem neuropathologic examination of a 6-case series of CAR T-cell treated patients

Introduction: Chimeric antigen receptor (CAR) T-cell therapy is a promising immunotherapy for the treatment of refractory hematopoietic malignancies. Adverse events are common, and neurotoxicity is one of the most important. However, the physiopathology is unknown and neuropathologic information is...

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Main Authors: Núria Vidal Robau, Gabriela Caballero, Ivan Archilla, Andrea Ladino, Sara Fernández, Valentín Ortiz-Maldonado, Montserrat Rovira, Marta Gómez-Hernando, Julio Delgado, María Suárez-Lledó, Carlos Fernández de Larrea, Olga Balagué, Gerard Frigola, Abel Muñoz, Estrella Ortiz, Teresa Ribalta, Miguel J. Martinez, Maria Angeles-Marcos, Marta Español-Rego, Azucena González, Daniel Benitez-Ribas, Eugenia Martinez-Hernandez, Pedro Castro, Iban Aldecoa
Format: Article
Language:English
Published: University of Münster / Open Journals System 2022-01-01
Series:Free Neuropathology
Subjects:
hematologic malignancies
chimeric antigen receptor (car) t-cells
cytokine release syndrome (crs)
neurotoxicity
neuropathology
immunohistochemical stains
Online Access:https://www.uni-muenster.de/Ejournals/index.php/fnp/article/view/4365

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