Antibody to gp41 MPER alters functional properties of HIV-1 Env without complete neutralization.

Antibody to gp41 MPER alters functional properties of HIV-1 Env without complete neutralization.

Human antibody 10E8 targets the conserved membrane proximal external region (MPER) of envelope glycoprotein (Env) subunit gp41 and neutralizes HIV-1 with exceptional potency. Remarkably, HIV-1 containing mutations that reportedly knockout 10E8 binding to linear MPER peptides are partially neutralize...

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Bibliographic Details
Main Authors:	Arthur S Kim, Daniel P Leaman, Michael B Zwick
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2014-07-01
Series:	PLoS Pathogens
Online Access:	http://europepmc.org/articles/PMC4110039?pdf=render

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