Characterization of Ag-Ion Releasing Zeolite Filled 3D Printed Resins
There has been profound growth in the use of 3D printed materials in dentistry in general, including orthodontics. The opportunity to impart antimicrobial properties to 3D printed parts from existing resins requires the capability of forming a stable colloid incorporating antimicrobial fillers. The...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-12-01
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| Series: | Journal of Functional Biomaterials |
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| Online Access: | https://www.mdpi.com/2079-4983/14/1/7 |
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| author | Marian O. Pacho Dylan Deeney Emily A. Johnson Bryanna N. Bravo Kishen Patel Mark A. Latta Michael A. Belshan Stephen M. Gross |
| author_facet | Marian O. Pacho Dylan Deeney Emily A. Johnson Bryanna N. Bravo Kishen Patel Mark A. Latta Michael A. Belshan Stephen M. Gross |
| author_sort | Marian O. Pacho |
| collection | DOAJ |
| description | There has been profound growth in the use of 3D printed materials in dentistry in general, including orthodontics. The opportunity to impart antimicrobial properties to 3D printed parts from existing resins requires the capability of forming a stable colloid incorporating antimicrobial fillers. The objective of this research was to characterize a colloid consisting of a 3D printable resin mixed with Ag-ion releasing zeolites and fumed silica to create 3D printed parts with antiviral properties. The final composite was tested for antiviral properties against SARS-CoV-2 and HIV-1. Antiviral activity was measured in terms of the half-life of SARS-CoV-2 and HIV-1 on the composite surface. The inclusion of the zeolite did not interfere with the kinetics measured on the surface of the ATR crystal. While the depth of cure, measured following ISO4049 guidelines, was reduced from 3.8 mm to 1.4 mm in 5 s, this greatly exceeded the resolution required for 3D printing. The colloid was stable for at least 6 months and the rheological behavior was dependent upon the fumed silica loading. The inclusion of zeolites and fumed silica significantly increased the flexural strength of the composite as measured by a 3 point bend test. The composite released approximately 2500 μg/L of silver ion per gram of composite as determined by potentiometry. There was a significant reduction of the average half-life of SARS-CoV-2 (1.9 fold) and HIV-1 (2.7 fold) on the surface of the composite. The inclusion of Ag-ion releasing zeolites into 3D-printable resin can result in stable colloids that generate composites with improved mechanical properties and antiviral properties. |
| first_indexed | 2024-03-09T12:08:15Z |
| format | Article |
| id | doaj.art-00debaf0dd4c4d7d80565deb7e9cdad6 |
| institution | Directory Open Access Journal |
| issn | 2079-4983 |
| language | English |
| last_indexed | 2024-03-09T12:08:15Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Functional Biomaterials |
| spelling | doaj.art-00debaf0dd4c4d7d80565deb7e9cdad62023-11-30T22:54:44ZengMDPI AGJournal of Functional Biomaterials2079-49832022-12-01141710.3390/jfb14010007Characterization of Ag-Ion Releasing Zeolite Filled 3D Printed ResinsMarian O. Pacho0Dylan Deeney1Emily A. Johnson2Bryanna N. Bravo3Kishen Patel4Mark A. Latta5Michael A. Belshan6Stephen M. Gross7Department of Oral Biology, School of Dentistry, Creighton University, Omaha, NE 68178, USADepartment of Medical Microbiology and Immunology, Creighton University, Omaha, NE 68178, USADepartment of Oral Biology, School of Dentistry, Creighton University, Omaha, NE 68178, USADepartment of Chemistry, College of Arts and Sciences, Creighton University, Omaha, NE 68178, USADepartment of Chemistry, College of Arts and Sciences, Creighton University, Omaha, NE 68178, USADepartment of Oral Biology, School of Dentistry, Creighton University, Omaha, NE 68178, USADepartment of Medical Microbiology and Immunology, Creighton University, Omaha, NE 68178, USADepartment of Oral Biology, School of Dentistry, Creighton University, Omaha, NE 68178, USAThere has been profound growth in the use of 3D printed materials in dentistry in general, including orthodontics. The opportunity to impart antimicrobial properties to 3D printed parts from existing resins requires the capability of forming a stable colloid incorporating antimicrobial fillers. The objective of this research was to characterize a colloid consisting of a 3D printable resin mixed with Ag-ion releasing zeolites and fumed silica to create 3D printed parts with antiviral properties. The final composite was tested for antiviral properties against SARS-CoV-2 and HIV-1. Antiviral activity was measured in terms of the half-life of SARS-CoV-2 and HIV-1 on the composite surface. The inclusion of the zeolite did not interfere with the kinetics measured on the surface of the ATR crystal. While the depth of cure, measured following ISO4049 guidelines, was reduced from 3.8 mm to 1.4 mm in 5 s, this greatly exceeded the resolution required for 3D printing. The colloid was stable for at least 6 months and the rheological behavior was dependent upon the fumed silica loading. The inclusion of zeolites and fumed silica significantly increased the flexural strength of the composite as measured by a 3 point bend test. The composite released approximately 2500 μg/L of silver ion per gram of composite as determined by potentiometry. There was a significant reduction of the average half-life of SARS-CoV-2 (1.9 fold) and HIV-1 (2.7 fold) on the surface of the composite. The inclusion of Ag-ion releasing zeolites into 3D-printable resin can result in stable colloids that generate composites with improved mechanical properties and antiviral properties.https://www.mdpi.com/2079-4983/14/1/73D printingzeolitesantiviraldental resinSARS-CoV2silver |
| spellingShingle | Marian O. Pacho Dylan Deeney Emily A. Johnson Bryanna N. Bravo Kishen Patel Mark A. Latta Michael A. Belshan Stephen M. Gross Characterization of Ag-Ion Releasing Zeolite Filled 3D Printed Resins Journal of Functional Biomaterials 3D printing zeolites antiviral dental resin SARS-CoV2 silver |
| title | Characterization of Ag-Ion Releasing Zeolite Filled 3D Printed Resins |
| title_full | Characterization of Ag-Ion Releasing Zeolite Filled 3D Printed Resins |
| title_fullStr | Characterization of Ag-Ion Releasing Zeolite Filled 3D Printed Resins |
| title_full_unstemmed | Characterization of Ag-Ion Releasing Zeolite Filled 3D Printed Resins |
| title_short | Characterization of Ag-Ion Releasing Zeolite Filled 3D Printed Resins |
| title_sort | characterization of ag ion releasing zeolite filled 3d printed resins |
| topic | 3D printing zeolites antiviral dental resin SARS-CoV2 silver |
| url | https://www.mdpi.com/2079-4983/14/1/7 |
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