Indoor-related microbe damage induces complement system activation in building users
In this comparative study, serum complement system antimicrobial activity was measured from 159 serum samples, taken from individuals from microbe-damaged (70 samples) and from reference buildings (89 samples). Antimicrobial activity was assessed using a probe-based bacterial Escherichia coli -lux b...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2021-01-01
|
| Series: | Innate Immunity |
| Online Access: | https://doi.org/10.1177/1753425920966641 |
| _version_ | 1828939697632575488 |
|---|---|
| author | Janne Atosuo Outi Karhuvaara Eetu Suominen Liisa Vilén Jari Nuutila Tuula Putus |
| author_facet | Janne Atosuo Outi Karhuvaara Eetu Suominen Liisa Vilén Jari Nuutila Tuula Putus |
| author_sort | Janne Atosuo |
| collection | DOAJ |
| description | In this comparative study, serum complement system antimicrobial activity was measured from 159 serum samples, taken from individuals from microbe-damaged (70 samples) and from reference buildings (89 samples). Antimicrobial activity was assessed using a probe-based bacterial Escherichia coli -lux bioluminescence system and comparison was made at a group level between the experimental and reference group. The complement activity was higher in users of microbe-damaged buildings compared with the reference group and the significant ( P < 0.001) increase in activity was found in the classical reaction pathway. This study strengthens our notion that exposure to indoor-related microbe damage increases the risk for systemic subclinical inflammation and creates a health risk for building users. |
| first_indexed | 2024-12-14T03:06:16Z |
| format | Article |
| id | doaj.art-00e22b9f7d1344bf91c9fbad385e5be8 |
| institution | Directory Open Access Journal |
| issn | 1753-4259 1753-4267 |
| language | English |
| last_indexed | 2024-12-14T03:06:16Z |
| publishDate | 2021-01-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Innate Immunity |
| spelling | doaj.art-00e22b9f7d1344bf91c9fbad385e5be82022-12-21T23:19:23ZengSAGE PublishingInnate Immunity1753-42591753-42672021-01-012710.1177/1753425920966641Indoor-related microbe damage induces complement system activation in building usersJanne AtosuoOuti KarhuvaaraEetu SuominenLiisa VilénJari NuutilaTuula PutusIn this comparative study, serum complement system antimicrobial activity was measured from 159 serum samples, taken from individuals from microbe-damaged (70 samples) and from reference buildings (89 samples). Antimicrobial activity was assessed using a probe-based bacterial Escherichia coli -lux bioluminescence system and comparison was made at a group level between the experimental and reference group. The complement activity was higher in users of microbe-damaged buildings compared with the reference group and the significant ( P < 0.001) increase in activity was found in the classical reaction pathway. This study strengthens our notion that exposure to indoor-related microbe damage increases the risk for systemic subclinical inflammation and creates a health risk for building users.https://doi.org/10.1177/1753425920966641 |
| spellingShingle | Janne Atosuo Outi Karhuvaara Eetu Suominen Liisa Vilén Jari Nuutila Tuula Putus Indoor-related microbe damage induces complement system activation in building users Innate Immunity |
| title | Indoor-related microbe damage induces complement system activation in building users |
| title_full | Indoor-related microbe damage induces complement system activation in building users |
| title_fullStr | Indoor-related microbe damage induces complement system activation in building users |
| title_full_unstemmed | Indoor-related microbe damage induces complement system activation in building users |
| title_short | Indoor-related microbe damage induces complement system activation in building users |
| title_sort | indoor related microbe damage induces complement system activation in building users |
| url | https://doi.org/10.1177/1753425920966641 |
| work_keys_str_mv | AT janneatosuo indoorrelatedmicrobedamageinducescomplementsystemactivationinbuildingusers AT outikarhuvaara indoorrelatedmicrobedamageinducescomplementsystemactivationinbuildingusers AT eetusuominen indoorrelatedmicrobedamageinducescomplementsystemactivationinbuildingusers AT liisavilen indoorrelatedmicrobedamageinducescomplementsystemactivationinbuildingusers AT jarinuutila indoorrelatedmicrobedamageinducescomplementsystemactivationinbuildingusers AT tuulaputus indoorrelatedmicrobedamageinducescomplementsystemactivationinbuildingusers |