The preventive effect of low-dose aspirin in a PPAR-γ antagonist treated mouse model of preeclampsia
Abstract Background Preeclampsia (PE) is one of the leading causes of maternal and perinatal mortality and morbidity. Low-dose aspirin (LDA) is the most widely used drug to prevent PE, but the recommended dose of LDA varies according to different guidelines. Peroxisome proliferator-activated recepto...
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| Format: | Article |
| Language: | English |
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BMC
2022-07-01
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| Series: | BMC Pregnancy and Childbirth |
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| Online Access: | https://doi.org/10.1186/s12884-022-04901-x |
| _version_ | 1818162818754543616 |
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| author | Yongbing Guo Yuchun Zhu Yu Sun Huixia Yang |
| author_facet | Yongbing Guo Yuchun Zhu Yu Sun Huixia Yang |
| author_sort | Yongbing Guo |
| collection | DOAJ |
| description | Abstract Background Preeclampsia (PE) is one of the leading causes of maternal and perinatal mortality and morbidity. Low-dose aspirin (LDA) is the most widely used drug to prevent PE, but the recommended dose of LDA varies according to different guidelines. Peroxisome proliferator-activated receptor (PPAR)-γ is involved in the formation of the placenta during pregnancy and is expressed in women with severe PE. In the present study, Our purpose was to investigate whether aspirin intervention in preeclampsia was related to PPAR-γ. Methods We administered pregnant mice with PPAR-γ-specific antagonist(T0070907) 2 mg/kg/d at 8.5–12.5 days of pregnancy. Mice treated with T0070907 developed key features of preeclampsia. Two doses of LDA (10 mg/kg/d and 20 mg/kg/d) were administered to the mice with a PE phenotype for intervention. Results LDA effectively decreased the increase in blood pressure in mice caused by T0070907 and decreased urinary protein levels and the urinary protein/creatinine ratio. LDA also inhibited the overexpression of endoglin and IL-β treated by T0070907. In addition, LDA evidently increased the placental weight and alleviates the degree of placental lesions of placenta and kidney. LDA alleviated the inhibition of PPAR-γ mRNA expression. The beneficial effect of 20 mg LDA was significantly better than that of 10 mg. Conclusions (1) LDA has a preventive effect against PE treated by PPAR-γ antagonist. (2) The preventive effect of LDA against PE is dose-dependent. |
| first_indexed | 2024-12-11T16:39:43Z |
| format | Article |
| id | doaj.art-00e57b7c23454282b3c1f7a1880f1167 |
| institution | Directory Open Access Journal |
| issn | 1471-2393 |
| language | English |
| last_indexed | 2024-12-11T16:39:43Z |
| publishDate | 2022-07-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Pregnancy and Childbirth |
| spelling | doaj.art-00e57b7c23454282b3c1f7a1880f11672022-12-22T00:58:21ZengBMCBMC Pregnancy and Childbirth1471-23932022-07-0122111110.1186/s12884-022-04901-xThe preventive effect of low-dose aspirin in a PPAR-γ antagonist treated mouse model of preeclampsiaYongbing Guo0Yuchun Zhu1Yu Sun2Huixia Yang3Department of Obstetrics and Gynecology, Peking University First HospitalDepartment of Obstetrics and Gynecology, Peking University First HospitalDepartment of Obstetrics and Gynecology, Peking University First HospitalDepartment of Obstetrics and Gynecology, Peking University First HospitalAbstract Background Preeclampsia (PE) is one of the leading causes of maternal and perinatal mortality and morbidity. Low-dose aspirin (LDA) is the most widely used drug to prevent PE, but the recommended dose of LDA varies according to different guidelines. Peroxisome proliferator-activated receptor (PPAR)-γ is involved in the formation of the placenta during pregnancy and is expressed in women with severe PE. In the present study, Our purpose was to investigate whether aspirin intervention in preeclampsia was related to PPAR-γ. Methods We administered pregnant mice with PPAR-γ-specific antagonist(T0070907) 2 mg/kg/d at 8.5–12.5 days of pregnancy. Mice treated with T0070907 developed key features of preeclampsia. Two doses of LDA (10 mg/kg/d and 20 mg/kg/d) were administered to the mice with a PE phenotype for intervention. Results LDA effectively decreased the increase in blood pressure in mice caused by T0070907 and decreased urinary protein levels and the urinary protein/creatinine ratio. LDA also inhibited the overexpression of endoglin and IL-β treated by T0070907. In addition, LDA evidently increased the placental weight and alleviates the degree of placental lesions of placenta and kidney. LDA alleviated the inhibition of PPAR-γ mRNA expression. The beneficial effect of 20 mg LDA was significantly better than that of 10 mg. Conclusions (1) LDA has a preventive effect against PE treated by PPAR-γ antagonist. (2) The preventive effect of LDA against PE is dose-dependent.https://doi.org/10.1186/s12884-022-04901-xPeroxisome proliferator-activated receptor-γLow-dose aspirinPreeclampsiaDose-dependent |
| spellingShingle | Yongbing Guo Yuchun Zhu Yu Sun Huixia Yang The preventive effect of low-dose aspirin in a PPAR-γ antagonist treated mouse model of preeclampsia BMC Pregnancy and Childbirth Peroxisome proliferator-activated receptor-γ Low-dose aspirin Preeclampsia Dose-dependent |
| title | The preventive effect of low-dose aspirin in a PPAR-γ antagonist treated mouse model of preeclampsia |
| title_full | The preventive effect of low-dose aspirin in a PPAR-γ antagonist treated mouse model of preeclampsia |
| title_fullStr | The preventive effect of low-dose aspirin in a PPAR-γ antagonist treated mouse model of preeclampsia |
| title_full_unstemmed | The preventive effect of low-dose aspirin in a PPAR-γ antagonist treated mouse model of preeclampsia |
| title_short | The preventive effect of low-dose aspirin in a PPAR-γ antagonist treated mouse model of preeclampsia |
| title_sort | preventive effect of low dose aspirin in a ppar γ antagonist treated mouse model of preeclampsia |
| topic | Peroxisome proliferator-activated receptor-γ Low-dose aspirin Preeclampsia Dose-dependent |
| url | https://doi.org/10.1186/s12884-022-04901-x |
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