Preliminary results of absorbable magnesium stent for treating eustachian tube dysfunction in a porcine model
Absorbable magnesium (Mg) stents have an attractive biocompatibility and rapid degradation rate, but their degradable behavior and efficacy in the Eustachian tube (ET) have not yet been investigated. In this study, the degradable behavior of the Mg stent in artificial nasal mucus was evaluated. The...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2023-01-01
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| Series: | PLoS ONE |
| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10128956/?tool=EBI |
| _version_ | 1797837880873189376 |
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| author | Jeon Min Kang Song Hee Kim Dae Sung Ryu Yubeen Park Dong-Sung Won Ji Won Kim Chu Hui Zeng Jung-Hoon Park Hong Ju Park |
| author_facet | Jeon Min Kang Song Hee Kim Dae Sung Ryu Yubeen Park Dong-Sung Won Ji Won Kim Chu Hui Zeng Jung-Hoon Park Hong Ju Park |
| author_sort | Jeon Min Kang |
| collection | DOAJ |
| description | Absorbable magnesium (Mg) stents have an attractive biocompatibility and rapid degradation rate, but their degradable behavior and efficacy in the Eustachian tube (ET) have not yet been investigated. In this study, the degradable behavior of the Mg stent in artificial nasal mucus was evaluated. The Mg stents in the porcine ET model were also investigated to evaluate their safety and efficacy. Four Mg stents were placed into the four ETs of two pigs. The mass loss rate of the Mg stents gradually decreased over time. The decrease rates were 30.96% at one week, 49.00% at two weeks, and 71.80% at four weeks. On the basis of histological findings, the thickness of submucosal tissue hyperplasia and the degree of inflammatory cell infiltration significantly decreased at four weeks compared with two weeks. Biodegradation of the Mg stent occurred before tissue proliferative reactions, and the ET patency was successfully maintained without stent-induced tissue hyperplasia at four weeks. The Mg stent that biodegrades rapidly seems to be effective and safe in porcine ET. Further investigation is required to verify the optimal stent shape and indwell period in the ET. |
| first_indexed | 2024-04-09T15:31:48Z |
| format | Article |
| id | doaj.art-00e5a987502a4ec38915a24cdecda83d |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-09T15:31:48Z |
| publishDate | 2023-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-00e5a987502a4ec38915a24cdecda83d2023-04-28T05:31:56ZengPublic Library of Science (PLoS)PLoS ONE1932-62032023-01-01184Preliminary results of absorbable magnesium stent for treating eustachian tube dysfunction in a porcine modelJeon Min KangSong Hee KimDae Sung RyuYubeen ParkDong-Sung WonJi Won KimChu Hui ZengJung-Hoon ParkHong Ju ParkAbsorbable magnesium (Mg) stents have an attractive biocompatibility and rapid degradation rate, but their degradable behavior and efficacy in the Eustachian tube (ET) have not yet been investigated. In this study, the degradable behavior of the Mg stent in artificial nasal mucus was evaluated. The Mg stents in the porcine ET model were also investigated to evaluate their safety and efficacy. Four Mg stents were placed into the four ETs of two pigs. The mass loss rate of the Mg stents gradually decreased over time. The decrease rates were 30.96% at one week, 49.00% at two weeks, and 71.80% at four weeks. On the basis of histological findings, the thickness of submucosal tissue hyperplasia and the degree of inflammatory cell infiltration significantly decreased at four weeks compared with two weeks. Biodegradation of the Mg stent occurred before tissue proliferative reactions, and the ET patency was successfully maintained without stent-induced tissue hyperplasia at four weeks. The Mg stent that biodegrades rapidly seems to be effective and safe in porcine ET. Further investigation is required to verify the optimal stent shape and indwell period in the ET.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10128956/?tool=EBI |
| spellingShingle | Jeon Min Kang Song Hee Kim Dae Sung Ryu Yubeen Park Dong-Sung Won Ji Won Kim Chu Hui Zeng Jung-Hoon Park Hong Ju Park Preliminary results of absorbable magnesium stent for treating eustachian tube dysfunction in a porcine model PLoS ONE |
| title | Preliminary results of absorbable magnesium stent for treating eustachian tube dysfunction in a porcine model |
| title_full | Preliminary results of absorbable magnesium stent for treating eustachian tube dysfunction in a porcine model |
| title_fullStr | Preliminary results of absorbable magnesium stent for treating eustachian tube dysfunction in a porcine model |
| title_full_unstemmed | Preliminary results of absorbable magnesium stent for treating eustachian tube dysfunction in a porcine model |
| title_short | Preliminary results of absorbable magnesium stent for treating eustachian tube dysfunction in a porcine model |
| title_sort | preliminary results of absorbable magnesium stent for treating eustachian tube dysfunction in a porcine model |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10128956/?tool=EBI |
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