A Built-In CpG Adjuvant in RSV F Protein DNA Vaccine Drives a Th1 Polarized and Enhanced Protective Immune Response

A Built-In CpG Adjuvant in RSV F Protein DNA Vaccine Drives a Th1 Polarized and Enhanced Protective Immune Response

Human respiratory syncytial virus (RSV) is the most significant cause of acute lower respiratory infection in children. However, there is no licensed vaccine available. Here, we investigated the effect of five or 20 copies of C-Class of CpG ODN (CpG-C) motif incorporated into a plasmid DNA vaccine e...

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Bibliographic Details
Main Authors: Yao Ma, Yue-Ying Jiao, Yun-Zhou Yu, Nan Jiang, Ying Hua, Xiu-Juan Zhang, Yuan-Hui Fu, Xiang-Lei Peng, Yan-Peng Zheng, Larry J. Anderson, Jin-Sheng He
Format: Article
Language:English
Published: MDPI AG 2018-01-01
Series:Viruses
Subjects:
human respiratory syncytial virus
CpG oligodeoxynucleotide
DNA vaccine
built-in adjuvant
protective immunity
Online Access:http://www.mdpi.com/1999-4915/10/1/38

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