Negative Survival Impact of High Radiation Doses to Neural Stem Cells Niches in an IDH-Wild-Type Glioblastoma Population
Aims: Assess the impact of radiation doses to neural stem cell (NSC) niches in patients with IDH-wild-type glioblastoma.Materials and Methods: Fifty patients were included in the study. NSC niches [SubVentricular Zone (SVZ) and Sub Granular Zone (SGZ)] were contoured by fusing CT scans and pre-thera...
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2018-10-01
|
| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fonc.2018.00426/full |
| _version_ | 1828944742298157056 |
|---|---|
| author | Xavier Muracciole Wassim El-amine Emmeline Tabouret Emmeline Tabouret Mohamed Boucekine Anne Barlier Gregorio Petrirena Tovo Harivony Laetitia Solignac Olivier L. Chinot Nicolas Macagno Nicolas Macagno Dominique Figarella-Branger Dominique Figarella-Branger Laetitia Padovani Laetitia Padovani |
| author_facet | Xavier Muracciole Wassim El-amine Emmeline Tabouret Emmeline Tabouret Mohamed Boucekine Anne Barlier Gregorio Petrirena Tovo Harivony Laetitia Solignac Olivier L. Chinot Nicolas Macagno Nicolas Macagno Dominique Figarella-Branger Dominique Figarella-Branger Laetitia Padovani Laetitia Padovani |
| author_sort | Xavier Muracciole |
| collection | DOAJ |
| description | Aims: Assess the impact of radiation doses to neural stem cell (NSC) niches in patients with IDH-wild-type glioblastoma.Materials and Methods: Fifty patients were included in the study. NSC niches [SubVentricular Zone (SVZ) and Sub Granular Zone (SGZ)] were contoured by fusing CT scans and pre-therapy MRI, Tumor location defined ipsilateral and contralateral SVZ and SGZ. Prognostic significance of clinical, biological and dosimetric parameters were examined. We generated a Recursive Partitioning Analysis (RPA) model with independent prognostic classes.Results: Median follow-up: 23.8 months. Event free and overall survival (OS): 10 and 19.1 months. Incomplete surgery, PTV (planning target volume), ipsilateral SVZ or NSC niche mean dose > 57.4 Gy, contralateral NSC niche mean dose > 35 Gy and bilateral NSC niche mean dose > 44 Gy were significantly correlated with reduced OS. Only EGFR amplification was an independent prognostic factor (p = 0.019) for OS. RPA generated independent risk groups: 1 (low risk): [ipsilateral NSC mean dose (INMD) < 58.01 Gy and methylated MGMT promoter], 2: (INMD < 58.01 Gy and unmethylated MGMT promoter and contralateral SVZ mean dose < 18.6 Gy; p = 0.43), 3: (INMD < 58.01 Gy and unmethylated MGMT promoter and contralateral SVZ mean dose > 18.6 Gy; p = 0.002) and 4: (very high risk) (INMD > 58.01 Gy; p < 0.001).Conclusion: High radiation doses to ipsilateral NSC and contralateral SVZ could have a negative impact on overall survival in IDH-wild-type glioblastoma population. |
| first_indexed | 2024-12-14T04:39:09Z |
| format | Article |
| id | doaj.art-00e71667928b4fa4b276377229e97e37 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-12-14T04:39:09Z |
| publishDate | 2018-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-00e71667928b4fa4b276377229e97e372022-12-21T23:16:50ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2018-10-01810.3389/fonc.2018.00426406047Negative Survival Impact of High Radiation Doses to Neural Stem Cells Niches in an IDH-Wild-Type Glioblastoma PopulationXavier Muracciole0Wassim El-amine1Emmeline Tabouret2Emmeline Tabouret3Mohamed Boucekine4Anne Barlier5Gregorio Petrirena6Tovo Harivony7Laetitia Solignac8Olivier L. Chinot9Nicolas Macagno10Nicolas Macagno11Dominique Figarella-Branger12Dominique Figarella-Branger13Laetitia Padovani14Laetitia Padovani15Radiotherapy Department, Assistance Publique des Hôpitaux de Marseille, Marseille, FranceRadiotherapy Department, Assistance Publique des Hôpitaux de Marseille, Marseille, FranceNeuro-Oncology Department, Assistance Publique des Hôpitaux de Marseille, Marseille, FranceAngiogenesis and Micro Environnment UMR 911 CRO2, Aix-Marseille University, Marseille, FranceUnity of Research EA3279, Aix-Marseille Université, Marseille, FranceMolecular Biology and Oncogenetics Department, Assistance Publique des Hôpitaux de Marseille, Marseille, FranceNeuro-Oncology Department, Assistance Publique des Hôpitaux de Marseille, Marseille, FranceRadiotherapy Department, Assistance Publique des Hôpitaux de Marseille, Marseille, FranceRadiotherapy Department, Assistance Publique des Hôpitaux de Marseille, Marseille, FranceNeuro-Oncology Department, Assistance Publique des Hôpitaux de Marseille, Marseille, FranceAngiogenesis and Micro Environnment UMR 911 CRO2, Aix-Marseille University, Marseille, FranceNeuropathology Department, Assistance Publique des Hôpitaux de Marseille, Marseille, FranceAngiogenesis and Micro Environnment UMR 911 CRO2, Aix-Marseille University, Marseille, FranceNeuropathology Department, Assistance Publique des Hôpitaux de Marseille, Marseille, FranceRadiotherapy Department, Assistance Publique des Hôpitaux de Marseille, Marseille, FranceCRCM INSERM UMR1068, CNRS UMR7258 AMU UM105, Genome Instability and Carcinogenesis, Institut Paoli-Calmettes, Marseille, FranceAims: Assess the impact of radiation doses to neural stem cell (NSC) niches in patients with IDH-wild-type glioblastoma.Materials and Methods: Fifty patients were included in the study. NSC niches [SubVentricular Zone (SVZ) and Sub Granular Zone (SGZ)] were contoured by fusing CT scans and pre-therapy MRI, Tumor location defined ipsilateral and contralateral SVZ and SGZ. Prognostic significance of clinical, biological and dosimetric parameters were examined. We generated a Recursive Partitioning Analysis (RPA) model with independent prognostic classes.Results: Median follow-up: 23.8 months. Event free and overall survival (OS): 10 and 19.1 months. Incomplete surgery, PTV (planning target volume), ipsilateral SVZ or NSC niche mean dose > 57.4 Gy, contralateral NSC niche mean dose > 35 Gy and bilateral NSC niche mean dose > 44 Gy were significantly correlated with reduced OS. Only EGFR amplification was an independent prognostic factor (p = 0.019) for OS. RPA generated independent risk groups: 1 (low risk): [ipsilateral NSC mean dose (INMD) < 58.01 Gy and methylated MGMT promoter], 2: (INMD < 58.01 Gy and unmethylated MGMT promoter and contralateral SVZ mean dose < 18.6 Gy; p = 0.43), 3: (INMD < 58.01 Gy and unmethylated MGMT promoter and contralateral SVZ mean dose > 18.6 Gy; p = 0.002) and 4: (very high risk) (INMD > 58.01 Gy; p < 0.001).Conclusion: High radiation doses to ipsilateral NSC and contralateral SVZ could have a negative impact on overall survival in IDH-wild-type glioblastoma population.https://www.frontiersin.org/article/10.3389/fonc.2018.00426/fullglioblastomaMGMTstem neural nichesradiotherapydosesurvival impact |
| spellingShingle | Xavier Muracciole Wassim El-amine Emmeline Tabouret Emmeline Tabouret Mohamed Boucekine Anne Barlier Gregorio Petrirena Tovo Harivony Laetitia Solignac Olivier L. Chinot Nicolas Macagno Nicolas Macagno Dominique Figarella-Branger Dominique Figarella-Branger Laetitia Padovani Laetitia Padovani Negative Survival Impact of High Radiation Doses to Neural Stem Cells Niches in an IDH-Wild-Type Glioblastoma Population Frontiers in Oncology glioblastoma MGMT stem neural niches radiotherapy dose survival impact |
| title | Negative Survival Impact of High Radiation Doses to Neural Stem Cells Niches in an IDH-Wild-Type Glioblastoma Population |
| title_full | Negative Survival Impact of High Radiation Doses to Neural Stem Cells Niches in an IDH-Wild-Type Glioblastoma Population |
| title_fullStr | Negative Survival Impact of High Radiation Doses to Neural Stem Cells Niches in an IDH-Wild-Type Glioblastoma Population |
| title_full_unstemmed | Negative Survival Impact of High Radiation Doses to Neural Stem Cells Niches in an IDH-Wild-Type Glioblastoma Population |
| title_short | Negative Survival Impact of High Radiation Doses to Neural Stem Cells Niches in an IDH-Wild-Type Glioblastoma Population |
| title_sort | negative survival impact of high radiation doses to neural stem cells niches in an idh wild type glioblastoma population |
| topic | glioblastoma MGMT stem neural niches radiotherapy dose survival impact |
| url | https://www.frontiersin.org/article/10.3389/fonc.2018.00426/full |
| work_keys_str_mv | AT xaviermuracciole negativesurvivalimpactofhighradiationdosestoneuralstemcellsnichesinanidhwildtypeglioblastomapopulation AT wassimelamine negativesurvivalimpactofhighradiationdosestoneuralstemcellsnichesinanidhwildtypeglioblastomapopulation AT emmelinetabouret negativesurvivalimpactofhighradiationdosestoneuralstemcellsnichesinanidhwildtypeglioblastomapopulation AT emmelinetabouret negativesurvivalimpactofhighradiationdosestoneuralstemcellsnichesinanidhwildtypeglioblastomapopulation AT mohamedboucekine negativesurvivalimpactofhighradiationdosestoneuralstemcellsnichesinanidhwildtypeglioblastomapopulation AT annebarlier negativesurvivalimpactofhighradiationdosestoneuralstemcellsnichesinanidhwildtypeglioblastomapopulation AT gregoriopetrirena negativesurvivalimpactofhighradiationdosestoneuralstemcellsnichesinanidhwildtypeglioblastomapopulation AT tovoharivony negativesurvivalimpactofhighradiationdosestoneuralstemcellsnichesinanidhwildtypeglioblastomapopulation AT laetitiasolignac negativesurvivalimpactofhighradiationdosestoneuralstemcellsnichesinanidhwildtypeglioblastomapopulation AT olivierlchinot negativesurvivalimpactofhighradiationdosestoneuralstemcellsnichesinanidhwildtypeglioblastomapopulation AT nicolasmacagno negativesurvivalimpactofhighradiationdosestoneuralstemcellsnichesinanidhwildtypeglioblastomapopulation AT nicolasmacagno negativesurvivalimpactofhighradiationdosestoneuralstemcellsnichesinanidhwildtypeglioblastomapopulation AT dominiquefigarellabranger negativesurvivalimpactofhighradiationdosestoneuralstemcellsnichesinanidhwildtypeglioblastomapopulation AT dominiquefigarellabranger negativesurvivalimpactofhighradiationdosestoneuralstemcellsnichesinanidhwildtypeglioblastomapopulation AT laetitiapadovani negativesurvivalimpactofhighradiationdosestoneuralstemcellsnichesinanidhwildtypeglioblastomapopulation AT laetitiapadovani negativesurvivalimpactofhighradiationdosestoneuralstemcellsnichesinanidhwildtypeglioblastomapopulation |