Zinc and Central Nervous System Disorders
Zinc (Zn<sup>2+</sup>) is the second most abundant necessary trace element in the human body, exerting a critical role in many physiological processes such as cellular proliferation, transcription, apoptosis, growth, immunity, and wound healing. It is an essential catalyst ion for many e...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-04-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/15/9/2140 |
| _version_ | 1797601973401288704 |
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| author | Bangqi Wang Tianshu Fang Hongping Chen |
| author_facet | Bangqi Wang Tianshu Fang Hongping Chen |
| author_sort | Bangqi Wang |
| collection | DOAJ |
| description | Zinc (Zn<sup>2+</sup>) is the second most abundant necessary trace element in the human body, exerting a critical role in many physiological processes such as cellular proliferation, transcription, apoptosis, growth, immunity, and wound healing. It is an essential catalyst ion for many enzymes and transcription factors. The maintenance of Zn<sup>2+</sup> homeostasis is essential for the central nervous system, in which Zn<sup>2+</sup> is abundantly distributed and accumulates in presynaptic vesicles. Synaptic Zn<sup>2+</sup> is necessary for neural transmission, playing a pivotal role in neurogenesis, cognition, memory, and learning. Emerging data suggest that disruption of Zn<sup>2+</sup> homeostasis is associated with several central nervous system disorders including Alzheimer’s disease, depression, Parkinson’s disease, multiple sclerosis, schizophrenia, epilepsy, and traumatic brain injury. Here, we reviewed the correlation between Zn<sup>2+</sup> and these central nervous system disorders. The potential mechanisms were also included. We hope that this review can provide new clues for the prevention and treatment of nervous system disorders. |
| first_indexed | 2024-03-11T04:09:41Z |
| format | Article |
| id | doaj.art-00ea0634f6784a139f00e7062363958c |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-11T04:09:41Z |
| publishDate | 2023-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-00ea0634f6784a139f00e7062363958c2023-11-17T23:29:40ZengMDPI AGNutrients2072-66432023-04-01159214010.3390/nu15092140Zinc and Central Nervous System DisordersBangqi Wang0Tianshu Fang1Hongping Chen2Department of Histology and Embryology, Medical College, Nanchang University, Nanchang 330006, ChinaDepartment of Histology and Embryology, Medical College, Nanchang University, Nanchang 330006, ChinaDepartment of Histology and Embryology, Medical College, Nanchang University, Nanchang 330006, ChinaZinc (Zn<sup>2+</sup>) is the second most abundant necessary trace element in the human body, exerting a critical role in many physiological processes such as cellular proliferation, transcription, apoptosis, growth, immunity, and wound healing. It is an essential catalyst ion for many enzymes and transcription factors. The maintenance of Zn<sup>2+</sup> homeostasis is essential for the central nervous system, in which Zn<sup>2+</sup> is abundantly distributed and accumulates in presynaptic vesicles. Synaptic Zn<sup>2+</sup> is necessary for neural transmission, playing a pivotal role in neurogenesis, cognition, memory, and learning. Emerging data suggest that disruption of Zn<sup>2+</sup> homeostasis is associated with several central nervous system disorders including Alzheimer’s disease, depression, Parkinson’s disease, multiple sclerosis, schizophrenia, epilepsy, and traumatic brain injury. Here, we reviewed the correlation between Zn<sup>2+</sup> and these central nervous system disorders. The potential mechanisms were also included. We hope that this review can provide new clues for the prevention and treatment of nervous system disorders.https://www.mdpi.com/2072-6643/15/9/2140zinccentral nervous systemneurodegenerationAlzheimer’s diseasedepressionParkinson’s disease |
| spellingShingle | Bangqi Wang Tianshu Fang Hongping Chen Zinc and Central Nervous System Disorders Nutrients zinc central nervous system neurodegeneration Alzheimer’s disease depression Parkinson’s disease |
| title | Zinc and Central Nervous System Disorders |
| title_full | Zinc and Central Nervous System Disorders |
| title_fullStr | Zinc and Central Nervous System Disorders |
| title_full_unstemmed | Zinc and Central Nervous System Disorders |
| title_short | Zinc and Central Nervous System Disorders |
| title_sort | zinc and central nervous system disorders |
| topic | zinc central nervous system neurodegeneration Alzheimer’s disease depression Parkinson’s disease |
| url | https://www.mdpi.com/2072-6643/15/9/2140 |
| work_keys_str_mv | AT bangqiwang zincandcentralnervoussystemdisorders AT tianshufang zincandcentralnervoussystemdisorders AT hongpingchen zincandcentralnervoussystemdisorders |