Polymer-Drug Anti-Thrombogenic and Hemocompatible Coatings as Surface Modifications
Since the 1960s, efforts have been made to develop new technologies to eliminate the risk of thrombosis in medical devices that come into contact with blood. Preventing thrombosis resulting from the contact of a medical device, such as an implant, with blood is a challenge due to the high mortality...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-03-01
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| Series: | Pharmaceutics |
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| Online Access: | https://www.mdpi.com/1999-4923/16/3/432 |
| _version_ | 1797239627762892800 |
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| author | Barbara Zawidlak-Węgrzyńska Joanna Rydz Marta Musioł Aneta Radziwon-Balicka |
| author_facet | Barbara Zawidlak-Węgrzyńska Joanna Rydz Marta Musioł Aneta Radziwon-Balicka |
| author_sort | Barbara Zawidlak-Węgrzyńska |
| collection | DOAJ |
| description | Since the 1960s, efforts have been made to develop new technologies to eliminate the risk of thrombosis in medical devices that come into contact with blood. Preventing thrombosis resulting from the contact of a medical device, such as an implant, with blood is a challenge due to the high mortality rate of patients and the high cost of medical care. To this end, various types of biomaterials coated with polymer-drug layers are being designed to reduce their thrombogenicity and improve their hemocompatibility. This review presents the latest developments in the use of polymer-drug systems to produce anti-thrombogenic surfaces in medical devices in contact with blood, such as stents, catheters, blood pumps, heart valves, artificial lungs, blood vessels, blood oxygenators, and various types of tubing (such as for hemodialysis) as well as microfluidic devices. This paper presents research directions and potential clinical applications, emphasizing the importance of continued progress and innovation in the field. |
| first_indexed | 2024-04-24T17:54:33Z |
| format | Article |
| id | doaj.art-00eaff41857848b3bed403763baf2c63 |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-04-24T17:54:33Z |
| publishDate | 2024-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-00eaff41857848b3bed403763baf2c632024-03-27T13:59:53ZengMDPI AGPharmaceutics1999-49232024-03-0116343210.3390/pharmaceutics16030432Polymer-Drug Anti-Thrombogenic and Hemocompatible Coatings as Surface ModificationsBarbara Zawidlak-Węgrzyńska0Joanna Rydz1Marta Musioł2Aneta Radziwon-Balicka3Department of Chemistry, Faculty of Medicine in Zabrze, Academy of Silesia in Katowice, 40-555 Katowice, PolandCentre of Polymer and Carbon Materials, Polish Academy of Sciences, 41-819 Zabrze, PolandCentre of Polymer and Carbon Materials, Polish Academy of Sciences, 41-819 Zabrze, PolandDepartment of Respiratory and Infectious Diseases, Center for Translational Research, Bispebjerg Hospital, University of Copenhagen, 1172 København, DenmarkSince the 1960s, efforts have been made to develop new technologies to eliminate the risk of thrombosis in medical devices that come into contact with blood. Preventing thrombosis resulting from the contact of a medical device, such as an implant, with blood is a challenge due to the high mortality rate of patients and the high cost of medical care. To this end, various types of biomaterials coated with polymer-drug layers are being designed to reduce their thrombogenicity and improve their hemocompatibility. This review presents the latest developments in the use of polymer-drug systems to produce anti-thrombogenic surfaces in medical devices in contact with blood, such as stents, catheters, blood pumps, heart valves, artificial lungs, blood vessels, blood oxygenators, and various types of tubing (such as for hemodialysis) as well as microfluidic devices. This paper presents research directions and potential clinical applications, emphasizing the importance of continued progress and innovation in the field.https://www.mdpi.com/1999-4923/16/3/432surface modificationdruganti-thrombogenic surface |
| spellingShingle | Barbara Zawidlak-Węgrzyńska Joanna Rydz Marta Musioł Aneta Radziwon-Balicka Polymer-Drug Anti-Thrombogenic and Hemocompatible Coatings as Surface Modifications Pharmaceutics surface modification drug anti-thrombogenic surface |
| title | Polymer-Drug Anti-Thrombogenic and Hemocompatible Coatings as Surface Modifications |
| title_full | Polymer-Drug Anti-Thrombogenic and Hemocompatible Coatings as Surface Modifications |
| title_fullStr | Polymer-Drug Anti-Thrombogenic and Hemocompatible Coatings as Surface Modifications |
| title_full_unstemmed | Polymer-Drug Anti-Thrombogenic and Hemocompatible Coatings as Surface Modifications |
| title_short | Polymer-Drug Anti-Thrombogenic and Hemocompatible Coatings as Surface Modifications |
| title_sort | polymer drug anti thrombogenic and hemocompatible coatings as surface modifications |
| topic | surface modification drug anti-thrombogenic surface |
| url | https://www.mdpi.com/1999-4923/16/3/432 |
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