Butyrate-producing human gut symbiont, Clostridium butyricum, and its role in health and disease
Clostridium butyricum is a butyrate-producing human gut symbiont that has been safely used as a probiotic for decades. C. butyricum strains have been investigated for potential protective or ameliorative effects in a wide range of human diseases, including gut-acquired infection, intestinal injury,...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2021-01-01
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| Series: | Gut Microbes |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/19490976.2021.1907272 |
| _version_ | 1818324052863877120 |
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| author | Magdalena K. Stoeva Jeewon Garcia-So Nicholas Justice Julia Myers Surabhi Tyagi Madeleine Nemchek Paul J. McMurdie Orville Kolterman John Eid |
| author_facet | Magdalena K. Stoeva Jeewon Garcia-So Nicholas Justice Julia Myers Surabhi Tyagi Madeleine Nemchek Paul J. McMurdie Orville Kolterman John Eid |
| author_sort | Magdalena K. Stoeva |
| collection | DOAJ |
| description | Clostridium butyricum is a butyrate-producing human gut symbiont that has been safely used as a probiotic for decades. C. butyricum strains have been investigated for potential protective or ameliorative effects in a wide range of human diseases, including gut-acquired infection, intestinal injury, irritable bowel syndrome, inflammatory bowel disease, neurodegenerative disease, metabolic disease, and colorectal cancer. In this review we summarize the studies on C. butyricum supplementation with special attention to proposed mechanisms for the associated health benefits and the supporting experimental evidence. These mechanisms center on molecular signals (especially butyrate) as well as immunological signals in the digestive system that cascade well beyond the gut to the liver, adipose tissue, brain, and more. The safety of probiotic C. butyricum strains appears well-established. We identify areas where additional human randomized controlled trials would provide valuable further data related to the strains’ utility as an intervention. |
| first_indexed | 2024-12-13T11:22:28Z |
| format | Article |
| id | doaj.art-00eb9a2a85fe4c38aefea5ce619ea619 |
| institution | Directory Open Access Journal |
| issn | 1949-0976 1949-0984 |
| language | English |
| last_indexed | 2024-12-13T11:22:28Z |
| publishDate | 2021-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Gut Microbes |
| spelling | doaj.art-00eb9a2a85fe4c38aefea5ce619ea6192022-12-21T23:48:25ZengTaylor & Francis GroupGut Microbes1949-09761949-09842021-01-0113110.1080/19490976.2021.19072721907272Butyrate-producing human gut symbiont, Clostridium butyricum, and its role in health and diseaseMagdalena K. Stoeva0Jeewon Garcia-So1Nicholas Justice2Julia Myers3Surabhi Tyagi4Madeleine Nemchek5Paul J. McMurdie6Orville Kolterman7John Eid8Pendulum Therapeutics, IncPendulum Therapeutics, IncPendulum Therapeutics, IncPendulum Therapeutics, IncPendulum Therapeutics, IncPendulum Therapeutics, IncPendulum Therapeutics, IncPendulum Therapeutics, IncPendulum Therapeutics, IncClostridium butyricum is a butyrate-producing human gut symbiont that has been safely used as a probiotic for decades. C. butyricum strains have been investigated for potential protective or ameliorative effects in a wide range of human diseases, including gut-acquired infection, intestinal injury, irritable bowel syndrome, inflammatory bowel disease, neurodegenerative disease, metabolic disease, and colorectal cancer. In this review we summarize the studies on C. butyricum supplementation with special attention to proposed mechanisms for the associated health benefits and the supporting experimental evidence. These mechanisms center on molecular signals (especially butyrate) as well as immunological signals in the digestive system that cascade well beyond the gut to the liver, adipose tissue, brain, and more. The safety of probiotic C. butyricum strains appears well-established. We identify areas where additional human randomized controlled trials would provide valuable further data related to the strains’ utility as an intervention.http://dx.doi.org/10.1080/19490976.2021.1907272clostridium butyricumshort chain fatty acidbutyrateimmunityintestinal barrierinflammationirritable bowel syndromemetabolic diseasecancerneurodegeneration |
| spellingShingle | Magdalena K. Stoeva Jeewon Garcia-So Nicholas Justice Julia Myers Surabhi Tyagi Madeleine Nemchek Paul J. McMurdie Orville Kolterman John Eid Butyrate-producing human gut symbiont, Clostridium butyricum, and its role in health and disease Gut Microbes clostridium butyricum short chain fatty acid butyrate immunity intestinal barrier inflammation irritable bowel syndrome metabolic disease cancer neurodegeneration |
| title | Butyrate-producing human gut symbiont, Clostridium butyricum, and its role in health and disease |
| title_full | Butyrate-producing human gut symbiont, Clostridium butyricum, and its role in health and disease |
| title_fullStr | Butyrate-producing human gut symbiont, Clostridium butyricum, and its role in health and disease |
| title_full_unstemmed | Butyrate-producing human gut symbiont, Clostridium butyricum, and its role in health and disease |
| title_short | Butyrate-producing human gut symbiont, Clostridium butyricum, and its role in health and disease |
| title_sort | butyrate producing human gut symbiont clostridium butyricum and its role in health and disease |
| topic | clostridium butyricum short chain fatty acid butyrate immunity intestinal barrier inflammation irritable bowel syndrome metabolic disease cancer neurodegeneration |
| url | http://dx.doi.org/10.1080/19490976.2021.1907272 |
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