Is there a role for B lymphocyte chimerism in the monitoring of B-acute lymphoblastic leukemia patients receiving allogeneic stem cell transplantation?
Objective: To determine the sensitivity and significance of B-cell chimerism for the detection of early engraftment, transplant rejection, and disease relapse. Methods: The dynamic monitoring of lineage-specific cell subtypes (B, T, and NK cells) was made in 20 B-cell acute lymphoblastic leukemia (B...
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| Format: | Article |
| Language: | English |
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Wiley
2015-03-01
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| Series: | Chronic Diseases and Translational Medicine |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2095882X15000055 |
| _version_ | 1811319685020385280 |
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| author | Yi-Ning Yang Xiao-Rui Wang You-Wen Qin Li-Ping Wan Ying Jiang Chun Wang |
| author_facet | Yi-Ning Yang Xiao-Rui Wang You-Wen Qin Li-Ping Wan Ying Jiang Chun Wang |
| author_sort | Yi-Ning Yang |
| collection | DOAJ |
| description | Objective: To determine the sensitivity and significance of B-cell chimerism for the detection of early engraftment, transplant rejection, and disease relapse. Methods: The dynamic monitoring of lineage-specific cell subtypes (B, T, and NK cells) was made in 20 B-cell acute lymphoblastic leukemia (B-ALL) patients following allogeneic hematopoietic stem cell transplantation (allo-HSCT). In the early period after allo-HSCT, the latest establishment of B-cell complete chimerism (CC) was observed in a majority of patients. Results: The percentage of donor cells of B-cell lineage was lower than the percent of T-cell lineage in most of the mixed chimerism (MC) patients. During graft rejection, the frequency of patients with decreasing MC of B-, T- and NK-cell lineage were 5/5, 2/5, and 2/5. When disease relapsed, five patients showed a faster decrease of the donor percent of B-cells than of T- or NK-cells. Only one patient displayed a more rapid decrease in NK-cells than in T- or B-cells. Conclusion: Monitoring of B-cell chimerism after HSCT seems to be valuable for insuring complete engraftment, anticipating graft rejection, and relapse in B-ALL patients. Keywords: B cell acute lymphoblastic leukemia (B-ALL), B-cell, T-cell, Chimerism, Allogeneic hematopoietic stem cell transplantation (allo-HSCT) |
| first_indexed | 2024-04-13T12:46:06Z |
| format | Article |
| id | doaj.art-00ebe62a75014ea78d576a7d41fd2321 |
| institution | Directory Open Access Journal |
| issn | 2095-882X |
| language | English |
| last_indexed | 2024-04-13T12:46:06Z |
| publishDate | 2015-03-01 |
| publisher | Wiley |
| record_format | Article |
| series | Chronic Diseases and Translational Medicine |
| spelling | doaj.art-00ebe62a75014ea78d576a7d41fd23212022-12-22T02:46:21ZengWileyChronic Diseases and Translational Medicine2095-882X2015-03-01114854Is there a role for B lymphocyte chimerism in the monitoring of B-acute lymphoblastic leukemia patients receiving allogeneic stem cell transplantation?Yi-Ning Yang0Xiao-Rui Wang1You-Wen Qin2Li-Ping Wan3Ying Jiang4Chun Wang5Department of Hematology, Shanghai Jiao Tong University affiliated with Shanghai General Hospital, Shanghai 200000, ChinaDepartment of Hematology, Shanghai Jiao Tong University affiliated with Shanghai General Hospital, Shanghai 200000, ChinaCorresponding author.; Department of Hematology, Shanghai Jiao Tong University affiliated with Shanghai General Hospital, Shanghai 200000, ChinaDepartment of Hematology, Shanghai Jiao Tong University affiliated with Shanghai General Hospital, Shanghai 200000, ChinaDepartment of Hematology, Shanghai Jiao Tong University affiliated with Shanghai General Hospital, Shanghai 200000, ChinaDepartment of Hematology, Shanghai Jiao Tong University affiliated with Shanghai General Hospital, Shanghai 200000, ChinaObjective: To determine the sensitivity and significance of B-cell chimerism for the detection of early engraftment, transplant rejection, and disease relapse. Methods: The dynamic monitoring of lineage-specific cell subtypes (B, T, and NK cells) was made in 20 B-cell acute lymphoblastic leukemia (B-ALL) patients following allogeneic hematopoietic stem cell transplantation (allo-HSCT). In the early period after allo-HSCT, the latest establishment of B-cell complete chimerism (CC) was observed in a majority of patients. Results: The percentage of donor cells of B-cell lineage was lower than the percent of T-cell lineage in most of the mixed chimerism (MC) patients. During graft rejection, the frequency of patients with decreasing MC of B-, T- and NK-cell lineage were 5/5, 2/5, and 2/5. When disease relapsed, five patients showed a faster decrease of the donor percent of B-cells than of T- or NK-cells. Only one patient displayed a more rapid decrease in NK-cells than in T- or B-cells. Conclusion: Monitoring of B-cell chimerism after HSCT seems to be valuable for insuring complete engraftment, anticipating graft rejection, and relapse in B-ALL patients. Keywords: B cell acute lymphoblastic leukemia (B-ALL), B-cell, T-cell, Chimerism, Allogeneic hematopoietic stem cell transplantation (allo-HSCT)http://www.sciencedirect.com/science/article/pii/S2095882X15000055 |
| spellingShingle | Yi-Ning Yang Xiao-Rui Wang You-Wen Qin Li-Ping Wan Ying Jiang Chun Wang Is there a role for B lymphocyte chimerism in the monitoring of B-acute lymphoblastic leukemia patients receiving allogeneic stem cell transplantation? Chronic Diseases and Translational Medicine |
| title | Is there a role for B lymphocyte chimerism in the monitoring of B-acute lymphoblastic leukemia patients receiving allogeneic stem cell transplantation? |
| title_full | Is there a role for B lymphocyte chimerism in the monitoring of B-acute lymphoblastic leukemia patients receiving allogeneic stem cell transplantation? |
| title_fullStr | Is there a role for B lymphocyte chimerism in the monitoring of B-acute lymphoblastic leukemia patients receiving allogeneic stem cell transplantation? |
| title_full_unstemmed | Is there a role for B lymphocyte chimerism in the monitoring of B-acute lymphoblastic leukemia patients receiving allogeneic stem cell transplantation? |
| title_short | Is there a role for B lymphocyte chimerism in the monitoring of B-acute lymphoblastic leukemia patients receiving allogeneic stem cell transplantation? |
| title_sort | is there a role for b lymphocyte chimerism in the monitoring of b acute lymphoblastic leukemia patients receiving allogeneic stem cell transplantation |
| url | http://www.sciencedirect.com/science/article/pii/S2095882X15000055 |
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