The dual role of autophagy in periprosthetic osteolysis
Periprosthetic osteolysis (PPO) induced by wear particles is an important cause of aseptic loosening after artificial joint replacement, among which the imbalance of osteogenesis and osteoclastic processes occupies a central position. The cells involved in PPO mainly include osteoclasts (macrophages...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-03-01
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| Series: | Frontiers in Cell and Developmental Biology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2023.1123753/full |
| _version_ | 1827980591342026752 |
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| author | Zhaoyang Yin Ge Gong Xiang Wang Wei Liu Bin Wang Jian Yin |
| author_facet | Zhaoyang Yin Ge Gong Xiang Wang Wei Liu Bin Wang Jian Yin |
| author_sort | Zhaoyang Yin |
| collection | DOAJ |
| description | Periprosthetic osteolysis (PPO) induced by wear particles is an important cause of aseptic loosening after artificial joint replacement, among which the imbalance of osteogenesis and osteoclastic processes occupies a central position. The cells involved in PPO mainly include osteoclasts (macrophages), osteoblasts, osteocytes, and fibroblasts. RANKL/RANK/OGP axis is a typical way for osteolysis. Autophagy, a mode of regulatory cell death and maintenance of cellular homeostasis, has a dual role in PPO. Although autophagy is activated in various periprosthetic cells and regulates the release of inflammatory cytokines, osteoclast activation, and osteoblast differentiation, its beneficial or detrimental role remains controversy. In particular, differences in the temporal control and intensity of autophagy may have different effects. This article focuses on the role of autophagy in PPO, and expects the regulation of autophagy to become a powerful target for clinical treatment of PPO. |
| first_indexed | 2024-04-09T21:55:55Z |
| format | Article |
| id | doaj.art-00ed6097e93245fcaa0b4ccda5ef0837 |
| institution | Directory Open Access Journal |
| issn | 2296-634X |
| language | English |
| last_indexed | 2024-04-09T21:55:55Z |
| publishDate | 2023-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj.art-00ed6097e93245fcaa0b4ccda5ef08372023-03-24T05:05:07ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2023-03-011110.3389/fcell.2023.11237531123753The dual role of autophagy in periprosthetic osteolysisZhaoyang Yin0Ge Gong1Xiang Wang2Wei Liu3Bin Wang4Jian Yin5Department of Orthopedics, The First People’s Hospital of Lianyungang, The Affiliated Lianyungang Hospital of Xuzhou Medical University, Lianyungang, ChinaDepartment of Geriatrics, Jinling Hospital, Medical School of Nanjing University, Nanjing, ChinaDepartment of Orthopedics, The Affiliated Jiangning Hospital with Nanjing Medical University, Nanjing, ChinaDepartment of Orthopedics, The Affiliated Jiangning Hospital with Nanjing Medical University, Nanjing, ChinaDepartment of Orthopedics, The Affiliated Jiangning Hospital with Nanjing Medical University, Nanjing, ChinaDepartment of Orthopedics, The Affiliated Jiangning Hospital with Nanjing Medical University, Nanjing, ChinaPeriprosthetic osteolysis (PPO) induced by wear particles is an important cause of aseptic loosening after artificial joint replacement, among which the imbalance of osteogenesis and osteoclastic processes occupies a central position. The cells involved in PPO mainly include osteoclasts (macrophages), osteoblasts, osteocytes, and fibroblasts. RANKL/RANK/OGP axis is a typical way for osteolysis. Autophagy, a mode of regulatory cell death and maintenance of cellular homeostasis, has a dual role in PPO. Although autophagy is activated in various periprosthetic cells and regulates the release of inflammatory cytokines, osteoclast activation, and osteoblast differentiation, its beneficial or detrimental role remains controversy. In particular, differences in the temporal control and intensity of autophagy may have different effects. This article focuses on the role of autophagy in PPO, and expects the regulation of autophagy to become a powerful target for clinical treatment of PPO.https://www.frontiersin.org/articles/10.3389/fcell.2023.1123753/fullperiprosthetic osteolysisautophagymitophagyaseptic looseningRANKL |
| spellingShingle | Zhaoyang Yin Ge Gong Xiang Wang Wei Liu Bin Wang Jian Yin The dual role of autophagy in periprosthetic osteolysis Frontiers in Cell and Developmental Biology periprosthetic osteolysis autophagy mitophagy aseptic loosening RANKL |
| title | The dual role of autophagy in periprosthetic osteolysis |
| title_full | The dual role of autophagy in periprosthetic osteolysis |
| title_fullStr | The dual role of autophagy in periprosthetic osteolysis |
| title_full_unstemmed | The dual role of autophagy in periprosthetic osteolysis |
| title_short | The dual role of autophagy in periprosthetic osteolysis |
| title_sort | dual role of autophagy in periprosthetic osteolysis |
| topic | periprosthetic osteolysis autophagy mitophagy aseptic loosening RANKL |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2023.1123753/full |
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