Prevalence and risk factors of cognitive impairment in Chinese patients with hypertension: a systematic review and meta-analysis
BackgroundCognitive impairment is prevalent in Chinese patients with hypertension; however, current evidence on prevalence and risk factors is required to be synthesized.ObjectivesThis systematic review and meta-analysis aimed to evaluate the prevalence and risk factors of cognitive impairment in Ch...
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| Format: | Article |
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Frontiers Media S.A.
2024-02-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2023.1271437/full |
| _version_ | 1797313018373079040 |
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| author | Cheng Xie Dongling Zhong Yue Zhang Xiaobo Liu Lili Zhang Xiao Luo Yimeng Gong Wei Jiang Rongjiang Jin Juan Li Juan Li |
| author_facet | Cheng Xie Dongling Zhong Yue Zhang Xiaobo Liu Lili Zhang Xiao Luo Yimeng Gong Wei Jiang Rongjiang Jin Juan Li Juan Li |
| author_sort | Cheng Xie |
| collection | DOAJ |
| description | BackgroundCognitive impairment is prevalent in Chinese patients with hypertension; however, current evidence on prevalence and risk factors is required to be synthesized.ObjectivesThis systematic review and meta-analysis aimed to evaluate the prevalence and risk factors of cognitive impairment in Chinese patients with hypertension.MethodsTwo reviewers independently searched PubMed, Web of Science, Embase, The Cochrane Library, CNKI, CBM, the Wanfang database, and the VIP database from their inception to 7 June 2023. The gray literature and the reference lists of the included studies were also retrieved manually. Moreover, we also independently performed the eligibility screening, data extraction, and data synthesis. The primary outcome was the prevalence of cognitive impairment in Chinese patients with hypertension, and the secondary outcomes were the risk factors for cognitive impairment in patients with hypertension. R (version 4.0.3) was used for data synthesis.ResultsIn total, 82 studies involving 53,623 patients with hypertension were included in this meta-analysis. The pooled prevalence of cognitive impairment in patients with hypertension was 37.6% (95% CI: 33.2–42.2%). A total of 12 risk factors, including advanced age (r = −0.34, 95% CI: −0.45, −0.21), female sex (OR = 1.15, 95% CI: 1.01–1.32), BMI > 24 Kg/m2 (OR = 1.76, 95% CI: 1.04–3.00), lower educational level (OR = 2.01, 95% CI: 1.10–3.67), single status (OR = 1.63, 95% CI: 1.32–2.02), complications with diabetes (OR = 1.44, 95% CI: 1.14–1.80), coronary heart disease (OR = 1.49, 95% CI: 1.12–1.97), higher stage of hypertension [stage 3 vs. stage 1, OR = 3.08, 95% CI: 1.82–5.22; stage 2 vs. stage 1, OR = 1.83, 95% CI: 1.29–2.60], no regular physical activity (OR = 0.40, 95% CI: 0.21–0.77), higher levels of systolic blood pressure (r = −0.25, 95% CI: −0.42, −0.08), Hcy (r = −0.39, 95% CI: −0.63, −0.09), and IL-6 (r = −0.26, 95% CI: −0.48, −0.02) were detected.ConclusionCognitive impairment is prevalent in Chinese patients with hypertension, and the increased prevalence was associated with several demographic characteristics, complicated disease, no regular physical activity, worse hypertension status (higher stages and SBP), and high levels of biomarkers. Therefore, more attention should be paid to the early identification and treatment of patients with hypertension who are at high risk for cognitive impairment in clinical practice. In addition, relevant risk factors should be controlled to reduce the incidence of cognitive impairment.Systematic review registrationhttp://www.crd.york.ac.uk/PROSPERO, identifier [CRD42023410437]. |
| first_indexed | 2024-03-08T02:23:40Z |
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| institution | Directory Open Access Journal |
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| language | English |
| last_indexed | 2024-03-08T02:23:40Z |
| publishDate | 2024-02-01 |
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| series | Frontiers in Neurology |
| spelling | doaj.art-00eebbdca2f440a687d4913e2defeeb22024-02-13T14:14:00ZengFrontiers Media S.A.Frontiers in Neurology1664-22952024-02-011410.3389/fneur.2023.12714371271437Prevalence and risk factors of cognitive impairment in Chinese patients with hypertension: a systematic review and meta-analysisCheng Xie0Dongling Zhong1Yue Zhang2Xiaobo Liu3Lili Zhang4Xiao Luo5Yimeng Gong6Wei Jiang7Rongjiang Jin8Juan Li9Juan Li10School of Health Preservation and Rehabilitation, Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaSchool of Health Preservation and Rehabilitation, Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaSchool of Health Preservation and Rehabilitation, Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaSchool of Health Preservation and Rehabilitation, Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaFirst Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, ChinaSchool of Health Preservation and Rehabilitation, Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaSchool of Health Preservation and Rehabilitation, Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaDepartment of Orthopedics, Pingshan County Hospital of Traditional Chinese Medicine, Yibing, ChinaSchool of Health Preservation and Rehabilitation, Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaSchool of Health Preservation and Rehabilitation, Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaAffiliated Sichuan Provincial Rehabilitation Hospital of Chengdu University of Traditional Chinese Medicine and Sichuan Provincial BAYI Rehabilitation Center, Chengdu, ChinaBackgroundCognitive impairment is prevalent in Chinese patients with hypertension; however, current evidence on prevalence and risk factors is required to be synthesized.ObjectivesThis systematic review and meta-analysis aimed to evaluate the prevalence and risk factors of cognitive impairment in Chinese patients with hypertension.MethodsTwo reviewers independently searched PubMed, Web of Science, Embase, The Cochrane Library, CNKI, CBM, the Wanfang database, and the VIP database from their inception to 7 June 2023. The gray literature and the reference lists of the included studies were also retrieved manually. Moreover, we also independently performed the eligibility screening, data extraction, and data synthesis. The primary outcome was the prevalence of cognitive impairment in Chinese patients with hypertension, and the secondary outcomes were the risk factors for cognitive impairment in patients with hypertension. R (version 4.0.3) was used for data synthesis.ResultsIn total, 82 studies involving 53,623 patients with hypertension were included in this meta-analysis. The pooled prevalence of cognitive impairment in patients with hypertension was 37.6% (95% CI: 33.2–42.2%). A total of 12 risk factors, including advanced age (r = −0.34, 95% CI: −0.45, −0.21), female sex (OR = 1.15, 95% CI: 1.01–1.32), BMI > 24 Kg/m2 (OR = 1.76, 95% CI: 1.04–3.00), lower educational level (OR = 2.01, 95% CI: 1.10–3.67), single status (OR = 1.63, 95% CI: 1.32–2.02), complications with diabetes (OR = 1.44, 95% CI: 1.14–1.80), coronary heart disease (OR = 1.49, 95% CI: 1.12–1.97), higher stage of hypertension [stage 3 vs. stage 1, OR = 3.08, 95% CI: 1.82–5.22; stage 2 vs. stage 1, OR = 1.83, 95% CI: 1.29–2.60], no regular physical activity (OR = 0.40, 95% CI: 0.21–0.77), higher levels of systolic blood pressure (r = −0.25, 95% CI: −0.42, −0.08), Hcy (r = −0.39, 95% CI: −0.63, −0.09), and IL-6 (r = −0.26, 95% CI: −0.48, −0.02) were detected.ConclusionCognitive impairment is prevalent in Chinese patients with hypertension, and the increased prevalence was associated with several demographic characteristics, complicated disease, no regular physical activity, worse hypertension status (higher stages and SBP), and high levels of biomarkers. Therefore, more attention should be paid to the early identification and treatment of patients with hypertension who are at high risk for cognitive impairment in clinical practice. In addition, relevant risk factors should be controlled to reduce the incidence of cognitive impairment.Systematic review registrationhttp://www.crd.york.ac.uk/PROSPERO, identifier [CRD42023410437].https://www.frontiersin.org/articles/10.3389/fneur.2023.1271437/fullcognitive impairmenthypertensionprevalencerisk factorsChinameta |
| spellingShingle | Cheng Xie Dongling Zhong Yue Zhang Xiaobo Liu Lili Zhang Xiao Luo Yimeng Gong Wei Jiang Rongjiang Jin Juan Li Juan Li Prevalence and risk factors of cognitive impairment in Chinese patients with hypertension: a systematic review and meta-analysis Frontiers in Neurology cognitive impairment hypertension prevalence risk factors China meta |
| title | Prevalence and risk factors of cognitive impairment in Chinese patients with hypertension: a systematic review and meta-analysis |
| title_full | Prevalence and risk factors of cognitive impairment in Chinese patients with hypertension: a systematic review and meta-analysis |
| title_fullStr | Prevalence and risk factors of cognitive impairment in Chinese patients with hypertension: a systematic review and meta-analysis |
| title_full_unstemmed | Prevalence and risk factors of cognitive impairment in Chinese patients with hypertension: a systematic review and meta-analysis |
| title_short | Prevalence and risk factors of cognitive impairment in Chinese patients with hypertension: a systematic review and meta-analysis |
| title_sort | prevalence and risk factors of cognitive impairment in chinese patients with hypertension a systematic review and meta analysis |
| topic | cognitive impairment hypertension prevalence risk factors China meta |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2023.1271437/full |
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