The Multifaceted Role of Curcumin in Advanced Nanocurcumin Form in the Treatment and Management of Chronic Disorders
Curcumin is the primary polyphenol in turmeric’s curcuminoid class. It has a wide range of therapeutic applications, such as anti-inflammatory, antioxidant, antidiabetic, hepatoprotective, antibacterial, and anticancer effects against various cancers, but has poor solubility and low bioavailability....
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| Format: | Article |
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MDPI AG
2021-11-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/26/23/7109 |
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| author | Priti Tagde Pooja Tagde Fahadul Islam Sandeep Tagde Muddaser Shah Zareen Delawar Hussain Md. Habibur Rahman Agnieszka Najda Ibtesam S. Alanazi Mousa O. Germoush Hanan R. H. Mohamed Mardi M. Algandaby Mohammed Z. Nasrullah Natalia Kot Mohamed M. Abdel-Daim |
| author_facet | Priti Tagde Pooja Tagde Fahadul Islam Sandeep Tagde Muddaser Shah Zareen Delawar Hussain Md. Habibur Rahman Agnieszka Najda Ibtesam S. Alanazi Mousa O. Germoush Hanan R. H. Mohamed Mardi M. Algandaby Mohammed Z. Nasrullah Natalia Kot Mohamed M. Abdel-Daim |
| author_sort | Priti Tagde |
| collection | DOAJ |
| description | Curcumin is the primary polyphenol in turmeric’s curcuminoid class. It has a wide range of therapeutic applications, such as anti-inflammatory, antioxidant, antidiabetic, hepatoprotective, antibacterial, and anticancer effects against various cancers, but has poor solubility and low bioavailability. Objective: To improve curcumin’s bioavailability, plasma concentration, and cellular permeability processes. The nanocurcumin approach over curcumin has been proven appropriate for encapsulating or loading curcumin (nanocurcumin) to increase its therapeutic potential. Conclusion: Though incorporating curcumin into nanocurcumin form may be a viable method for overcoming its intrinsic limitations, and there are reasonable concerns regarding its toxicological safety once it enters biological pathways. This review article mainly highlights the therapeutic benefits of nanocurcumin over curcumin. |
| first_indexed | 2024-03-10T04:47:57Z |
| format | Article |
| id | doaj.art-00f04822612a45eebb08235a3eb9c0ea |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-10T04:47:57Z |
| publishDate | 2021-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-00f04822612a45eebb08235a3eb9c0ea2023-11-23T02:47:30ZengMDPI AGMolecules1420-30492021-11-012623710910.3390/molecules26237109The Multifaceted Role of Curcumin in Advanced Nanocurcumin Form in the Treatment and Management of Chronic DisordersPriti Tagde0Pooja Tagde1Fahadul Islam2Sandeep Tagde3Muddaser Shah4Zareen Delawar Hussain5Md. Habibur Rahman6Agnieszka Najda7Ibtesam S. Alanazi8Mousa O. Germoush9Hanan R. H. Mohamed10Mardi M. Algandaby11Mohammed Z. Nasrullah12Natalia Kot13Mohamed M. Abdel-Daim14Amity Institute of Pharmacy, Amity University, Noida 201303, IndiaPractice of Medicine Department, Government Homeopathy College, Bhopa l462016, IndiaDepartment of Pharmacy, Faculty of Allied Health Sciences, Daffodil International University, Dhaka 1207, BangladeshPRISAL Foundation (Pharmaceutical Royal International Society), Bhopa l462026, IndiaDepartment of Botany, Abdul Wali Khan University Mardan, Mardan 23200, PakistanIntegro Pharma Ltd., Dhaka 1206, BangladeshDepartment of Pharmacy, Southeast University, Banani, Dhaka 1213, BangladeshDepartment of Vegetable and Herbal Crops, University of Life Sciences in Lublin, 50A Doświadczalna Street, 20-280 Lublin, PolandDepartment of Biology, Faculty of Sciences, University of Hafr Al Batin, Hafr Al Batin 39524, Saudi ArabiaBiology Department, College of Science, Jouf University, Sakaka P.O. Box 2014, Saudi ArabiaZoology Department, Faculty of Science, Cairo University, Giza 12613, EgyptDepartment of Biological Sciences, Faculty of Science, King Abdulaziz University, Jeddah 21589, Saudi ArabiaDepartment of Pharmacology and Toxicology, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi ArabiaDepartment of Landscape Architecture, University of Life Science in Lublin, 28 Gleboka Street, 20-612 Lublin, PolandPharmacy Program, Department of Pharmaceutical Sciences, Batterjee Medical College, Jeddah 21442, Saudi ArabiaCurcumin is the primary polyphenol in turmeric’s curcuminoid class. It has a wide range of therapeutic applications, such as anti-inflammatory, antioxidant, antidiabetic, hepatoprotective, antibacterial, and anticancer effects against various cancers, but has poor solubility and low bioavailability. Objective: To improve curcumin’s bioavailability, plasma concentration, and cellular permeability processes. The nanocurcumin approach over curcumin has been proven appropriate for encapsulating or loading curcumin (nanocurcumin) to increase its therapeutic potential. Conclusion: Though incorporating curcumin into nanocurcumin form may be a viable method for overcoming its intrinsic limitations, and there are reasonable concerns regarding its toxicological safety once it enters biological pathways. This review article mainly highlights the therapeutic benefits of nanocurcumin over curcumin.https://www.mdpi.com/1420-3049/26/23/7109nanocurcuminsolubilityantioxidant effectanti-inflammatory actionanticancerneurodegenerative disease |
| spellingShingle | Priti Tagde Pooja Tagde Fahadul Islam Sandeep Tagde Muddaser Shah Zareen Delawar Hussain Md. Habibur Rahman Agnieszka Najda Ibtesam S. Alanazi Mousa O. Germoush Hanan R. H. Mohamed Mardi M. Algandaby Mohammed Z. Nasrullah Natalia Kot Mohamed M. Abdel-Daim The Multifaceted Role of Curcumin in Advanced Nanocurcumin Form in the Treatment and Management of Chronic Disorders Molecules nanocurcumin solubility antioxidant effect anti-inflammatory action anticancer neurodegenerative disease |
| title | The Multifaceted Role of Curcumin in Advanced Nanocurcumin Form in the Treatment and Management of Chronic Disorders |
| title_full | The Multifaceted Role of Curcumin in Advanced Nanocurcumin Form in the Treatment and Management of Chronic Disorders |
| title_fullStr | The Multifaceted Role of Curcumin in Advanced Nanocurcumin Form in the Treatment and Management of Chronic Disorders |
| title_full_unstemmed | The Multifaceted Role of Curcumin in Advanced Nanocurcumin Form in the Treatment and Management of Chronic Disorders |
| title_short | The Multifaceted Role of Curcumin in Advanced Nanocurcumin Form in the Treatment and Management of Chronic Disorders |
| title_sort | multifaceted role of curcumin in advanced nanocurcumin form in the treatment and management of chronic disorders |
| topic | nanocurcumin solubility antioxidant effect anti-inflammatory action anticancer neurodegenerative disease |
| url | https://www.mdpi.com/1420-3049/26/23/7109 |
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