Microscopies Enabled by Photonic Metamaterials
In recent years, the biosensor research community has made rapid progress in the development of nanostructured materials capable of amplifying the interaction between light and biological matter. A common objective is to concentrate the electromagnetic energy associated with light into nanometer-sca...
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MDPI AG
2022-01-01
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| Series: | Sensors |
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| Online Access: | https://www.mdpi.com/1424-8220/22/3/1086 |
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| author | Yanyu Xiong Nantao Li Congnyu Che Weijing Wang Priyash Barya Weinan Liu Leyang Liu Xiaojing Wang Shaoxiong Wu Huan Hu Brian T. Cunningham |
| author_facet | Yanyu Xiong Nantao Li Congnyu Che Weijing Wang Priyash Barya Weinan Liu Leyang Liu Xiaojing Wang Shaoxiong Wu Huan Hu Brian T. Cunningham |
| author_sort | Yanyu Xiong |
| collection | DOAJ |
| description | In recent years, the biosensor research community has made rapid progress in the development of nanostructured materials capable of amplifying the interaction between light and biological matter. A common objective is to concentrate the electromagnetic energy associated with light into nanometer-scale volumes that, in many cases, can extend below the conventional Abbé diffraction limit. Dating back to the first application of surface plasmon resonance (SPR) for label-free detection of biomolecular interactions, resonant optical structures, including waveguides, ring resonators, and photonic crystals, have proven to be effective conduits for a wide range of optical enhancement effects that include enhanced excitation of photon emitters (such as quantum dots, organic dyes, and fluorescent proteins), enhanced extraction from photon emitters, enhanced optical absorption, and enhanced optical scattering (such as from Raman-scatterers and nanoparticles). The application of photonic metamaterials as a means for enhancing contrast in microscopy is a recent technological development. Through their ability to generate surface-localized and resonantly enhanced electromagnetic fields, photonic metamaterials are an effective surface for magnifying absorption, photon emission, and scattering associated with biological materials while an imaging system records spatial and temporal patterns. By replacing the conventional glass microscope slide with a photonic metamaterial, new forms of contrast and enhanced signal-to-noise are obtained for applications that include cancer diagnostics, infectious disease diagnostics, cell membrane imaging, biomolecular interaction analysis, and drug discovery. This paper will review the current state of the art in which photonic metamaterial surfaces are utilized in the context of microscopy. |
| first_indexed | 2024-03-09T23:07:27Z |
| format | Article |
| id | doaj.art-00f0a6890b3c4318b751a940911f8ba8 |
| institution | Directory Open Access Journal |
| issn | 1424-8220 |
| language | English |
| last_indexed | 2024-03-09T23:07:27Z |
| publishDate | 2022-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Sensors |
| spelling | doaj.art-00f0a6890b3c4318b751a940911f8ba82023-11-23T17:50:16ZengMDPI AGSensors1424-82202022-01-01223108610.3390/s22031086Microscopies Enabled by Photonic MetamaterialsYanyu Xiong0Nantao Li1Congnyu Che2Weijing Wang3Priyash Barya4Weinan Liu5Leyang Liu6Xiaojing Wang7Shaoxiong Wu8Huan Hu9Brian T. Cunningham10Department of Electrical and Computer Engineering, University of Illinois at Urbana-Champaign, Champaign, IL 61822, USADepartment of Electrical and Computer Engineering, University of Illinois at Urbana-Champaign, Champaign, IL 61822, USAHolonyak Micro and Nanotechnology Laboratory, Champaign, IL 61822, USAHolonyak Micro and Nanotechnology Laboratory, Champaign, IL 61822, USADepartment of Electrical and Computer Engineering, University of Illinois at Urbana-Champaign, Champaign, IL 61822, USADepartment of Electrical and Computer Engineering, University of Illinois at Urbana-Champaign, Champaign, IL 61822, USADepartment of Electrical and Computer Engineering, University of Illinois at Urbana-Champaign, Champaign, IL 61822, USAHolonyak Micro and Nanotechnology Laboratory, Champaign, IL 61822, USAZhejiang University-University of Illinois at Urbana-Champaign Institute, International Campus, Zhejiang University, Haining 314400, ChinaZhejiang University-University of Illinois at Urbana-Champaign Institute, International Campus, Zhejiang University, Haining 314400, ChinaDepartment of Electrical and Computer Engineering, University of Illinois at Urbana-Champaign, Champaign, IL 61822, USAIn recent years, the biosensor research community has made rapid progress in the development of nanostructured materials capable of amplifying the interaction between light and biological matter. A common objective is to concentrate the electromagnetic energy associated with light into nanometer-scale volumes that, in many cases, can extend below the conventional Abbé diffraction limit. Dating back to the first application of surface plasmon resonance (SPR) for label-free detection of biomolecular interactions, resonant optical structures, including waveguides, ring resonators, and photonic crystals, have proven to be effective conduits for a wide range of optical enhancement effects that include enhanced excitation of photon emitters (such as quantum dots, organic dyes, and fluorescent proteins), enhanced extraction from photon emitters, enhanced optical absorption, and enhanced optical scattering (such as from Raman-scatterers and nanoparticles). The application of photonic metamaterials as a means for enhancing contrast in microscopy is a recent technological development. Through their ability to generate surface-localized and resonantly enhanced electromagnetic fields, photonic metamaterials are an effective surface for magnifying absorption, photon emission, and scattering associated with biological materials while an imaging system records spatial and temporal patterns. By replacing the conventional glass microscope slide with a photonic metamaterial, new forms of contrast and enhanced signal-to-noise are obtained for applications that include cancer diagnostics, infectious disease diagnostics, cell membrane imaging, biomolecular interaction analysis, and drug discovery. This paper will review the current state of the art in which photonic metamaterial surfaces are utilized in the context of microscopy.https://www.mdpi.com/1424-8220/22/3/1086photonic metamaterialsmicroscopyplasmonicphotonic crystalslabel-freefluorescence |
| spellingShingle | Yanyu Xiong Nantao Li Congnyu Che Weijing Wang Priyash Barya Weinan Liu Leyang Liu Xiaojing Wang Shaoxiong Wu Huan Hu Brian T. Cunningham Microscopies Enabled by Photonic Metamaterials Sensors photonic metamaterials microscopy plasmonic photonic crystals label-free fluorescence |
| title | Microscopies Enabled by Photonic Metamaterials |
| title_full | Microscopies Enabled by Photonic Metamaterials |
| title_fullStr | Microscopies Enabled by Photonic Metamaterials |
| title_full_unstemmed | Microscopies Enabled by Photonic Metamaterials |
| title_short | Microscopies Enabled by Photonic Metamaterials |
| title_sort | microscopies enabled by photonic metamaterials |
| topic | photonic metamaterials microscopy plasmonic photonic crystals label-free fluorescence |
| url | https://www.mdpi.com/1424-8220/22/3/1086 |
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