Fucoxanthin Inhibits Myofibroblast Differentiation and Extracellular Matrix Production in Nasal Polyp-Derived Fibroblasts via Modulation of Smad-Dependent and Smad-Independent Signaling Pathways

Fucoxanthin Inhibits Myofibroblast Differentiation and Extracellular Matrix Production in Nasal Polyp-Derived Fibroblasts via Modulation of Smad-Dependent and Smad-Independent Signaling Pathways

Nasal polyps (NPs) are a multifactorial disorder associated with a chronic inflammatory state of the nasal mucosa. Fucoxanthin (Fx) is a characteristic orange carotenoid obtained from brown algae and has diverse immunological properties. The present study investigated whether Fx inhibits fibrosis-re...

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Bibliographic Details
Main Authors: Hyun Jung, Dae-Sung Lee, Seong Kook Park, Jung Sik Choi, Won-Kyo Jung, Won Sun Park, Il-Whan Choi
Format: Article
Language:English
Published: MDPI AG 2018-09-01
Series:Marine Drugs
Subjects:
nasal polyps
fucoxantin
transforming growth factor
extracellular matrix accumulation
fibroblasts
Online Access:http://www.mdpi.com/1660-3397/16/9/323

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