Localized Gastric Amyloidosis with Kappa and Lambda Light Chain Co-Expression
Esophagogastroduodenoscopy for cancer screening was performed in a 55-year-old woman as part of a health screening program, and revealed a depressed lesion approximately 20 mm in diameter in the lesser curvature of the mid-gastric body. Several biopsy specimens were collected as the lesion resembled...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Korean Society of Gastrointestinal Endoscopy
2018-05-01
|
| Series: | Clinical Endoscopy |
| Subjects: | |
| Online Access: | http://www.e-ce.org/upload/pdf/ce-2017-118.pdf |
| _version_ | 1797642615615651840 |
|---|---|
| author | Yong Hwan Ahn Ye Young Rhee Suck Chei Choi Geom Seog Seo |
| author_facet | Yong Hwan Ahn Ye Young Rhee Suck Chei Choi Geom Seog Seo |
| author_sort | Yong Hwan Ahn |
| collection | DOAJ |
| description | Esophagogastroduodenoscopy for cancer screening was performed in a 55-year-old woman as part of a health screening program, and revealed a depressed lesion approximately 20 mm in diameter in the lesser curvature of the mid-gastric body. Several biopsy specimens were collected as the lesion resembled early gastric cancer; however, histopathologic evaluation revealed chronic active gastritis with an ulcer and amorphous eosinophilic material deposition. Congo red staining identified amyloid proteins, and apple-green birefringence was shown using polarized light microscopy. Immunohistochemical staining revealed the presence of kappa and lambda chain-positive plasma cells. There was no evidence of underlying plasma cell dyscrasia or amyloid deposition in other segments of the gastrointestinal tract. Echocardiography and computed tomography of the chest, abdomen, and pelvis did not show any significant findings. Thus, the patient was diagnosed with localized gastric amyloidosis with kappa and lambda light chain coexpression. |
| first_indexed | 2024-03-11T14:02:53Z |
| format | Article |
| id | doaj.art-00f36f3ca5a8404daeb4bf99c033d2ad |
| institution | Directory Open Access Journal |
| issn | 2234-2400 2234-2443 |
| language | English |
| last_indexed | 2024-03-11T14:02:53Z |
| publishDate | 2018-05-01 |
| publisher | Korean Society of Gastrointestinal Endoscopy |
| record_format | Article |
| series | Clinical Endoscopy |
| spelling | doaj.art-00f36f3ca5a8404daeb4bf99c033d2ad2023-11-02T03:39:27ZengKorean Society of Gastrointestinal EndoscopyClinical Endoscopy2234-24002234-24432018-05-0151328528810.5946/ce.2017.1187047Localized Gastric Amyloidosis with Kappa and Lambda Light Chain Co-ExpressionYong Hwan Ahn0Ye Young Rhee1Suck Chei Choi2Geom Seog Seo3 Department of Internal Medicine, Plus Internal Medicine Clinic, Suncheon, Korea Anatomic Pathology Reference Lab, Seegene Medical Foundation, Seoul, Korea Department of Internal medicine, Digestive Disease Research Institute, Wonkwang University College of Medicine, Iksan, Korea Department of Internal medicine, Digestive Disease Research Institute, Wonkwang University College of Medicine, Iksan, KoreaEsophagogastroduodenoscopy for cancer screening was performed in a 55-year-old woman as part of a health screening program, and revealed a depressed lesion approximately 20 mm in diameter in the lesser curvature of the mid-gastric body. Several biopsy specimens were collected as the lesion resembled early gastric cancer; however, histopathologic evaluation revealed chronic active gastritis with an ulcer and amorphous eosinophilic material deposition. Congo red staining identified amyloid proteins, and apple-green birefringence was shown using polarized light microscopy. Immunohistochemical staining revealed the presence of kappa and lambda chain-positive plasma cells. There was no evidence of underlying plasma cell dyscrasia or amyloid deposition in other segments of the gastrointestinal tract. Echocardiography and computed tomography of the chest, abdomen, and pelvis did not show any significant findings. Thus, the patient was diagnosed with localized gastric amyloidosis with kappa and lambda light chain coexpression.http://www.e-ce.org/upload/pdf/ce-2017-118.pdfLocalized gastric amyloidosisLight chain amyloidosisCo-expression |
| spellingShingle | Yong Hwan Ahn Ye Young Rhee Suck Chei Choi Geom Seog Seo Localized Gastric Amyloidosis with Kappa and Lambda Light Chain Co-Expression Clinical Endoscopy Localized gastric amyloidosis Light chain amyloidosis Co-expression |
| title | Localized Gastric Amyloidosis with Kappa and Lambda Light Chain Co-Expression |
| title_full | Localized Gastric Amyloidosis with Kappa and Lambda Light Chain Co-Expression |
| title_fullStr | Localized Gastric Amyloidosis with Kappa and Lambda Light Chain Co-Expression |
| title_full_unstemmed | Localized Gastric Amyloidosis with Kappa and Lambda Light Chain Co-Expression |
| title_short | Localized Gastric Amyloidosis with Kappa and Lambda Light Chain Co-Expression |
| title_sort | localized gastric amyloidosis with kappa and lambda light chain co expression |
| topic | Localized gastric amyloidosis Light chain amyloidosis Co-expression |
| url | http://www.e-ce.org/upload/pdf/ce-2017-118.pdf |
| work_keys_str_mv | AT yonghwanahn localizedgastricamyloidosiswithkappaandlambdalightchaincoexpression AT yeyoungrhee localizedgastricamyloidosiswithkappaandlambdalightchaincoexpression AT suckcheichoi localizedgastricamyloidosiswithkappaandlambdalightchaincoexpression AT geomseogseo localizedgastricamyloidosiswithkappaandlambdalightchaincoexpression |