A Case of Cushing’s Syndrome from Well-Differentiated Neuroendocrine Tumors of the Small Bowel and Its Mesentery
Adrenocorticotropic (ACTH)-producing neuroendocrine tumours (NETs) are rarely found in the small bowel, and primary mesenteric NETs have only been reported in a few cases globally. We report the case of a 68-year-old female with ectopic Cushing’s syndrome due to excessive ACTH secretion from small b...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-04-01
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| Series: | Current Oncology |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1718-7729/30/4/312 |
| _version_ | 1797605758285643776 |
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| author | Kirsten Rose Carlaw Ahmer Hameed Anthony Shakeshaft |
| author_facet | Kirsten Rose Carlaw Ahmer Hameed Anthony Shakeshaft |
| author_sort | Kirsten Rose Carlaw |
| collection | DOAJ |
| description | Adrenocorticotropic (ACTH)-producing neuroendocrine tumours (NETs) are rarely found in the small bowel, and primary mesenteric NETs have only been reported in a few cases globally. We report the case of a 68-year-old female with ectopic Cushing’s syndrome due to excessive ACTH secretion from small bowel primary lesions and mesenteric metastasis. Initially, only the mesenteric mass was detected on imaging and endoscopy/colonoscopy, and it was only with surgical exploration that the small bowel lesions were found. This highlights the importance of high clinical suspicion and robust investigation when locating NETs. Surgical resection of the affected small bowel and mesentery was the definitive treatment for this patient. Initial hydrocortisone replacement therapy was needed, and subsequent biochemical tests and clinical reviews demonstrated no recurrence. |
| first_indexed | 2024-03-11T05:05:36Z |
| format | Article |
| id | doaj.art-00f4637d88d54494873d464911e5081c |
| institution | Directory Open Access Journal |
| issn | 1198-0052 1718-7729 |
| language | English |
| last_indexed | 2024-03-11T05:05:36Z |
| publishDate | 2023-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Current Oncology |
| spelling | doaj.art-00f4637d88d54494873d464911e5081c2023-11-17T18:52:59ZengMDPI AGCurrent Oncology1198-00521718-77292023-04-013044110411610.3390/curroncol30040312A Case of Cushing’s Syndrome from Well-Differentiated Neuroendocrine Tumors of the Small Bowel and Its MesenteryKirsten Rose Carlaw0Ahmer Hameed1Anthony Shakeshaft2Colorectal Surgery Department, Nepean Hospital, Kingswood, NSW 2747, AustraliaColorectal Surgery Department, Nepean Hospital, Kingswood, NSW 2747, AustraliaColorectal Surgery Department, Nepean Hospital, Kingswood, NSW 2747, AustraliaAdrenocorticotropic (ACTH)-producing neuroendocrine tumours (NETs) are rarely found in the small bowel, and primary mesenteric NETs have only been reported in a few cases globally. We report the case of a 68-year-old female with ectopic Cushing’s syndrome due to excessive ACTH secretion from small bowel primary lesions and mesenteric metastasis. Initially, only the mesenteric mass was detected on imaging and endoscopy/colonoscopy, and it was only with surgical exploration that the small bowel lesions were found. This highlights the importance of high clinical suspicion and robust investigation when locating NETs. Surgical resection of the affected small bowel and mesentery was the definitive treatment for this patient. Initial hydrocortisone replacement therapy was needed, and subsequent biochemical tests and clinical reviews demonstrated no recurrence.https://www.mdpi.com/1718-7729/30/4/312ectopic ACTHneuroendocrine tumourNETmesenteric NETsmall bowel NET |
| spellingShingle | Kirsten Rose Carlaw Ahmer Hameed Anthony Shakeshaft A Case of Cushing’s Syndrome from Well-Differentiated Neuroendocrine Tumors of the Small Bowel and Its Mesentery Current Oncology ectopic ACTH neuroendocrine tumour NET mesenteric NET small bowel NET |
| title | A Case of Cushing’s Syndrome from Well-Differentiated Neuroendocrine Tumors of the Small Bowel and Its Mesentery |
| title_full | A Case of Cushing’s Syndrome from Well-Differentiated Neuroendocrine Tumors of the Small Bowel and Its Mesentery |
| title_fullStr | A Case of Cushing’s Syndrome from Well-Differentiated Neuroendocrine Tumors of the Small Bowel and Its Mesentery |
| title_full_unstemmed | A Case of Cushing’s Syndrome from Well-Differentiated Neuroendocrine Tumors of the Small Bowel and Its Mesentery |
| title_short | A Case of Cushing’s Syndrome from Well-Differentiated Neuroendocrine Tumors of the Small Bowel and Its Mesentery |
| title_sort | case of cushing s syndrome from well differentiated neuroendocrine tumors of the small bowel and its mesentery |
| topic | ectopic ACTH neuroendocrine tumour NET mesenteric NET small bowel NET |
| url | https://www.mdpi.com/1718-7729/30/4/312 |
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