Natural Aporphine Alkaloids with Potential to Impact Metabolic Syndrome
The incidence and prevalence of metabolic syndrome has steadily increased worldwide. As a major risk factor for various diseases, metabolic syndrome has come into focus in recent years. Some natural aporphine alkaloids are very promising agents in the prevention and treatment of metabolic syndrome a...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-10-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/26/20/6117 |
| _version_ | 1827679002243891200 |
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| author | Fei-Xuan Wang Nan Zhu Fan Zhou Dong-Xiang Lin |
| author_facet | Fei-Xuan Wang Nan Zhu Fan Zhou Dong-Xiang Lin |
| author_sort | Fei-Xuan Wang |
| collection | DOAJ |
| description | The incidence and prevalence of metabolic syndrome has steadily increased worldwide. As a major risk factor for various diseases, metabolic syndrome has come into focus in recent years. Some natural aporphine alkaloids are very promising agents in the prevention and treatment of metabolic syndrome and its components because of their wide variety of biological activities. These natural aporphine alkaloids have protective effects on the different risk factors characterizing metabolic syndrome. In this review, we highlight the activities of bioactive aporphine alkaloids: thaliporphine, boldine, nuciferine, pronuciferine, roemerine, dicentrine, magnoflorine, anonaine, apomorphine, glaucine, predicentrine, isolaureline, xylopine, methylbulbocapnine, and crebanine. We particularly focused on their impact on metabolic syndrome and its components, including insulin resistance and type 2 diabetes mellitus, endothelial dysfunction, hypertension and cardiovascular disease, hyperlipidemia and obesity, non-alcoholic fatty liver disease, hyperuricemia and kidney damage, erectile dysfunction, central nervous system-related disorder, and intestinal microbiota dysbiosis. We also discussed the potential mechanisms of actions by aporphine alkaloids in metabolic syndrome. |
| first_indexed | 2024-03-10T06:20:42Z |
| format | Article |
| id | doaj.art-00f4b7f322a74e91a6c93ef7cb95b165 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-10T06:20:42Z |
| publishDate | 2021-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-00f4b7f322a74e91a6c93ef7cb95b1652023-11-22T19:18:16ZengMDPI AGMolecules1420-30492021-10-012620611710.3390/molecules26206117Natural Aporphine Alkaloids with Potential to Impact Metabolic SyndromeFei-Xuan Wang0Nan Zhu1Fan Zhou2Dong-Xiang Lin3Nanjing Institute of Product Quality Inspection, Nanjing 210019, ChinaNanjing Institute of Product Quality Inspection, Nanjing 210019, ChinaNanjing Institute of Product Quality Inspection, Nanjing 210019, ChinaNanjing Institute of Product Quality Inspection, Nanjing 210019, ChinaThe incidence and prevalence of metabolic syndrome has steadily increased worldwide. As a major risk factor for various diseases, metabolic syndrome has come into focus in recent years. Some natural aporphine alkaloids are very promising agents in the prevention and treatment of metabolic syndrome and its components because of their wide variety of biological activities. These natural aporphine alkaloids have protective effects on the different risk factors characterizing metabolic syndrome. In this review, we highlight the activities of bioactive aporphine alkaloids: thaliporphine, boldine, nuciferine, pronuciferine, roemerine, dicentrine, magnoflorine, anonaine, apomorphine, glaucine, predicentrine, isolaureline, xylopine, methylbulbocapnine, and crebanine. We particularly focused on their impact on metabolic syndrome and its components, including insulin resistance and type 2 diabetes mellitus, endothelial dysfunction, hypertension and cardiovascular disease, hyperlipidemia and obesity, non-alcoholic fatty liver disease, hyperuricemia and kidney damage, erectile dysfunction, central nervous system-related disorder, and intestinal microbiota dysbiosis. We also discussed the potential mechanisms of actions by aporphine alkaloids in metabolic syndrome.https://www.mdpi.com/1420-3049/26/20/6117natural aporphine alkaloidsmetabolic syndromethaliporphineboldinenuciferine |
| spellingShingle | Fei-Xuan Wang Nan Zhu Fan Zhou Dong-Xiang Lin Natural Aporphine Alkaloids with Potential to Impact Metabolic Syndrome Molecules natural aporphine alkaloids metabolic syndrome thaliporphine boldine nuciferine |
| title | Natural Aporphine Alkaloids with Potential to Impact Metabolic Syndrome |
| title_full | Natural Aporphine Alkaloids with Potential to Impact Metabolic Syndrome |
| title_fullStr | Natural Aporphine Alkaloids with Potential to Impact Metabolic Syndrome |
| title_full_unstemmed | Natural Aporphine Alkaloids with Potential to Impact Metabolic Syndrome |
| title_short | Natural Aporphine Alkaloids with Potential to Impact Metabolic Syndrome |
| title_sort | natural aporphine alkaloids with potential to impact metabolic syndrome |
| topic | natural aporphine alkaloids metabolic syndrome thaliporphine boldine nuciferine |
| url | https://www.mdpi.com/1420-3049/26/20/6117 |
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