Oropharynx HPV status and its relation to HIV infection
Background The number of oropharyngeal lesions caused by HPV (Human papillomavirus) has been increasing worldwide in the past years. In spite of the clinical relevance of HPV infection in the anogenital tract of HIV-positive patients, the relevance of oropharynx HPV infection in these patients is no...
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PeerJ Inc.
2018-03-01
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| Online Access: | https://peerj.com/articles/4407.pdf |
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| author | Leonora Maciel de Souza Vianna Fabiana Pirani Carneiro Rivadavio Amorim Eliete Neves da Silva Guerra Florêncio Figueiredo Cavalcanti Neto Valdenize Tiziani Andrea Barretto Motoyama Anamélia Lorenzetti Bocca |
| author_facet | Leonora Maciel de Souza Vianna Fabiana Pirani Carneiro Rivadavio Amorim Eliete Neves da Silva Guerra Florêncio Figueiredo Cavalcanti Neto Valdenize Tiziani Andrea Barretto Motoyama Anamélia Lorenzetti Bocca |
| author_sort | Leonora Maciel de Souza Vianna |
| collection | DOAJ |
| description | Background The number of oropharyngeal lesions caused by HPV (Human papillomavirus) has been increasing worldwide in the past years. In spite of the clinical relevance of HPV infection in the anogenital tract of HIV-positive patients, the relevance of oropharynx HPV infection in these patients is not clear. The aim of the present study was to detect HPV infection, and clinical and cytological changes in the oropharynx of HIV-positive patients. Methods Samples collected from the oropharynx of 100 HIV-positive patients were subjected to hybrid capture (HC), conventional and liquid-based cytology. Clinical data were also collected to investigate the relation with HPV status. Results High and low-risk types of HPV were present in 8% and 16.7% of the total sample. The mean ± sd (maximum-minimum) of the relative ratio light unit (RLU)/cutoff (CO) was 2.94 ± 2.58 (1.09–7.87) and 1.61 ± 0.65 (1.07–2.8) for high- and low-risk-HPV, respectively. By cytology, dysplasia was not detected, but atypical squamous cells of undetermined significance (ASC-US) were diagnosed in two samples. No clinical change, suggestive of dysplasia/cancer, was detected. Conclusion Our study was able to detect and characterize HPV infection by hybrid capture, which may represent a good tool for screening and follow-up of HPV in the studied population. The frequency and viral load of HPV were low. Neither clinical nor cytological changes suggestive of dysplasia/neoplasia were observed in oropharynx of HIV-positive patients. |
| first_indexed | 2024-03-09T07:26:45Z |
| format | Article |
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| issn | 2167-8359 |
| language | English |
| last_indexed | 2024-03-09T07:26:45Z |
| publishDate | 2018-03-01 |
| publisher | PeerJ Inc. |
| record_format | Article |
| series | PeerJ |
| spelling | doaj.art-00f6f15d18284ed0bead2ba87cb66fea2023-12-03T06:52:11ZengPeerJ Inc.PeerJ2167-83592018-03-016e440710.7717/peerj.4407Oropharynx HPV status and its relation to HIV infectionLeonora Maciel de Souza Vianna0Fabiana Pirani Carneiro1Rivadavio Amorim2Eliete Neves da Silva Guerra3Florêncio Figueiredo Cavalcanti Neto4Valdenize Tiziani5Andrea Barretto Motoyama6Anamélia Lorenzetti Bocca7Department of Pathology, School of Medicine, University of Brasilia (UnB), Brasíla, DF, BrazilDepartment of Pathology, School of Medicine, University of Brasilia (UnB), Brasíla, DF, BrazilDepartment of Pathology, School of Medicine, University of Brasilia (UnB), Brasíla, DF, BrazilDepartment of Oral Pathology, School of Dentistry, University of Brasilia (UnB), Brasilia, DF, BrazilDepartment of Pathology, School of Medicine, University of Brasilia (UnB), Brasíla, DF, BrazilCenter for Learning and Research, Brasilia Children Hospital, Brasilia-DF, DF, BrasilDepartment of Pathology, School of Medicine, University of Brasilia (UnB), Brasíla, DF, BrazilDepartment of Pathology, School of Medicine, University of Brasilia (UnB), Brasíla, DF, BrazilBackground The number of oropharyngeal lesions caused by HPV (Human papillomavirus) has been increasing worldwide in the past years. In spite of the clinical relevance of HPV infection in the anogenital tract of HIV-positive patients, the relevance of oropharynx HPV infection in these patients is not clear. The aim of the present study was to detect HPV infection, and clinical and cytological changes in the oropharynx of HIV-positive patients. Methods Samples collected from the oropharynx of 100 HIV-positive patients were subjected to hybrid capture (HC), conventional and liquid-based cytology. Clinical data were also collected to investigate the relation with HPV status. Results High and low-risk types of HPV were present in 8% and 16.7% of the total sample. The mean ± sd (maximum-minimum) of the relative ratio light unit (RLU)/cutoff (CO) was 2.94 ± 2.58 (1.09–7.87) and 1.61 ± 0.65 (1.07–2.8) for high- and low-risk-HPV, respectively. By cytology, dysplasia was not detected, but atypical squamous cells of undetermined significance (ASC-US) were diagnosed in two samples. No clinical change, suggestive of dysplasia/cancer, was detected. Conclusion Our study was able to detect and characterize HPV infection by hybrid capture, which may represent a good tool for screening and follow-up of HPV in the studied population. The frequency and viral load of HPV were low. Neither clinical nor cytological changes suggestive of dysplasia/neoplasia were observed in oropharynx of HIV-positive patients.https://peerj.com/articles/4407.pdfAcquired Immunodeficiency SyndromeOropharynxHuman Papillomavirus TestHuman PapillomavirusHIV |
| spellingShingle | Leonora Maciel de Souza Vianna Fabiana Pirani Carneiro Rivadavio Amorim Eliete Neves da Silva Guerra Florêncio Figueiredo Cavalcanti Neto Valdenize Tiziani Andrea Barretto Motoyama Anamélia Lorenzetti Bocca Oropharynx HPV status and its relation to HIV infection PeerJ Acquired Immunodeficiency Syndrome Oropharynx Human Papillomavirus Test Human Papillomavirus HIV |
| title | Oropharynx HPV status and its relation to HIV infection |
| title_full | Oropharynx HPV status and its relation to HIV infection |
| title_fullStr | Oropharynx HPV status and its relation to HIV infection |
| title_full_unstemmed | Oropharynx HPV status and its relation to HIV infection |
| title_short | Oropharynx HPV status and its relation to HIV infection |
| title_sort | oropharynx hpv status and its relation to hiv infection |
| topic | Acquired Immunodeficiency Syndrome Oropharynx Human Papillomavirus Test Human Papillomavirus HIV |
| url | https://peerj.com/articles/4407.pdf |
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