Self-synergistic effect of Prussian blue nanoparticles for cancer therapy: driving photothermal therapy and reducing hyperthermia-induced side effects
Abstract Background Photothermal therapy (PTT), involving application of localized hyperthermia to kill cancer cells, has attracted wide attention in cancer therapy. The production of reactive oxygen species (ROS) during PTT may cause irreversible damage to healthy tissues around the tumor. Simultan...
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| Format: | Article |
| Language: | English |
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BMC
2021-05-01
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| Series: | Journal of Nanobiotechnology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12951-021-00819-2 |
| _version_ | 1811186026370039808 |
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| author | Xue Xie Wei Gao Junnian Hao Jianrong Wu Xiaojun Cai Yuanyi Zheng |
| author_facet | Xue Xie Wei Gao Junnian Hao Jianrong Wu Xiaojun Cai Yuanyi Zheng |
| author_sort | Xue Xie |
| collection | DOAJ |
| description | Abstract Background Photothermal therapy (PTT), involving application of localized hyperthermia to kill cancer cells, has attracted wide attention in cancer therapy. The production of reactive oxygen species (ROS) during PTT may cause irreversible damage to healthy tissues around the tumor. Simultaneously, hyperthermia can stimulate inflammatory response, thus promoting tumor recurrence and metastasis. Therefore, it is of paramount importance to reduce the undesired side effects for further development of PTT. Results Using a hydrothermal method, spherical Prussian blue nanoparticles (PBs) with uniform size were prepared. The PBs exhibited good dispersion and stability in saline with an average hydrodynamic size of 110 nm. The prepared PBs had a high photothermal conversion efficiency and photothermal stability. The PBs showed intrinsic ROS scavenging properties in vitro. Antioxidant and anti-inflammatory effects of PBs were also observed in vivo. Assessment of toxicity and endoplasmic reticulum stress-inducing ability showed that PBs did not induce an inflammatory response. Tissues of major organs of mice stained with hematoxylin–eosin showed no significant damage, indicating good biocompatibility and safety of PBs. Conclusion The designed single-component PBs with intrinsic ROS scavenging and anti-inflammatory properties could avoid inflammatory response and heat stress-induced ROS during PTT. Thus, further research on PBs is worthwhile to achieve their clinical translation and promote the development of PTT. |
| first_indexed | 2024-04-11T13:39:19Z |
| format | Article |
| id | doaj.art-00f732ef3ac244d7a447ab9d652d4d52 |
| institution | Directory Open Access Journal |
| issn | 1477-3155 |
| language | English |
| last_indexed | 2024-04-11T13:39:19Z |
| publishDate | 2021-05-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Nanobiotechnology |
| spelling | doaj.art-00f732ef3ac244d7a447ab9d652d4d522022-12-22T04:21:19ZengBMCJournal of Nanobiotechnology1477-31552021-05-0119111410.1186/s12951-021-00819-2Self-synergistic effect of Prussian blue nanoparticles for cancer therapy: driving photothermal therapy and reducing hyperthermia-induced side effectsXue Xie0Wei Gao1Junnian Hao2Jianrong Wu3Xiaojun Cai4Yuanyi Zheng5Shanghai Institute of Ultrasound in Medicine, Shanghai Jiao Tong University Affiliated Sixth People’s HospitalShanghai Institute of Ultrasound in Medicine, Shanghai Jiao Tong University Affiliated Sixth People’s HospitalShanghai Institute of Ultrasound in Medicine, Shanghai Jiao Tong University Affiliated Sixth People’s HospitalShanghai Institute of Ultrasound in Medicine, Shanghai Jiao Tong University Affiliated Sixth People’s HospitalShanghai Institute of Ultrasound in Medicine, Shanghai Jiao Tong University Affiliated Sixth People’s HospitalShanghai Institute of Ultrasound in Medicine, Shanghai Jiao Tong University Affiliated Sixth People’s HospitalAbstract Background Photothermal therapy (PTT), involving application of localized hyperthermia to kill cancer cells, has attracted wide attention in cancer therapy. The production of reactive oxygen species (ROS) during PTT may cause irreversible damage to healthy tissues around the tumor. Simultaneously, hyperthermia can stimulate inflammatory response, thus promoting tumor recurrence and metastasis. Therefore, it is of paramount importance to reduce the undesired side effects for further development of PTT. Results Using a hydrothermal method, spherical Prussian blue nanoparticles (PBs) with uniform size were prepared. The PBs exhibited good dispersion and stability in saline with an average hydrodynamic size of 110 nm. The prepared PBs had a high photothermal conversion efficiency and photothermal stability. The PBs showed intrinsic ROS scavenging properties in vitro. Antioxidant and anti-inflammatory effects of PBs were also observed in vivo. Assessment of toxicity and endoplasmic reticulum stress-inducing ability showed that PBs did not induce an inflammatory response. Tissues of major organs of mice stained with hematoxylin–eosin showed no significant damage, indicating good biocompatibility and safety of PBs. Conclusion The designed single-component PBs with intrinsic ROS scavenging and anti-inflammatory properties could avoid inflammatory response and heat stress-induced ROS during PTT. Thus, further research on PBs is worthwhile to achieve their clinical translation and promote the development of PTT.https://doi.org/10.1186/s12951-021-00819-2Photothermal therapyInflammationReactive oxygen speciesPrussian blue |
| spellingShingle | Xue Xie Wei Gao Junnian Hao Jianrong Wu Xiaojun Cai Yuanyi Zheng Self-synergistic effect of Prussian blue nanoparticles for cancer therapy: driving photothermal therapy and reducing hyperthermia-induced side effects Journal of Nanobiotechnology Photothermal therapy Inflammation Reactive oxygen species Prussian blue |
| title | Self-synergistic effect of Prussian blue nanoparticles for cancer therapy: driving photothermal therapy and reducing hyperthermia-induced side effects |
| title_full | Self-synergistic effect of Prussian blue nanoparticles for cancer therapy: driving photothermal therapy and reducing hyperthermia-induced side effects |
| title_fullStr | Self-synergistic effect of Prussian blue nanoparticles for cancer therapy: driving photothermal therapy and reducing hyperthermia-induced side effects |
| title_full_unstemmed | Self-synergistic effect of Prussian blue nanoparticles for cancer therapy: driving photothermal therapy and reducing hyperthermia-induced side effects |
| title_short | Self-synergistic effect of Prussian blue nanoparticles for cancer therapy: driving photothermal therapy and reducing hyperthermia-induced side effects |
| title_sort | self synergistic effect of prussian blue nanoparticles for cancer therapy driving photothermal therapy and reducing hyperthermia induced side effects |
| topic | Photothermal therapy Inflammation Reactive oxygen species Prussian blue |
| url | https://doi.org/10.1186/s12951-021-00819-2 |
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