TFIP11 promotes replication fork reversal to preserve genome stability

Abstract Replication fork reversal, a critical protective mechanism against replication stress in higher eukaryotic cells, is orchestrated via a series of coordinated enzymatic reactions. The Bloom syndrome gene product, BLM, a member of the highly conserved RecQ helicase family, is implicated in th...

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Bibliographic Details
Main Authors: Junliang Chen, Mingjie Wu, Yulan Yang, Chunyan Ruan, Yi Luo, Lizhi Song, Ting Wu, Jun Huang, Bing Yang, Ting Liu
Format: Article
Language:English
Published: Nature Portfolio 2024-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-45684-3