Role of Apoptosis in Wound Healing and Apoptosis Alterations in Microgravity
Functioning as the outermost self-renewing protective layer of the human organism, skin protects against a multitude of harmful biological and physical stimuli. Consisting of ectodermal, mesenchymal, and neural crest-derived cell lineages, tissue homeostasis, and signal transduction are finely tuned...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-06-01
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| Series: | Frontiers in Bioengineering and Biotechnology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fbioe.2021.679650/full |
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| author | Stefan Riwaldt Thomas J. Corydon Thomas J. Corydon Desiré Pantalone Jayashree Sahana Petra Wise Markus Wehland Markus Wehland Marcus Krüger Marcus Krüger Daniela Melnik Sascha Kopp Sascha Kopp Manfred Infanger Manfred Infanger Daniela Grimm Daniela Grimm Daniela Grimm |
| author_facet | Stefan Riwaldt Thomas J. Corydon Thomas J. Corydon Desiré Pantalone Jayashree Sahana Petra Wise Markus Wehland Markus Wehland Marcus Krüger Marcus Krüger Daniela Melnik Sascha Kopp Sascha Kopp Manfred Infanger Manfred Infanger Daniela Grimm Daniela Grimm Daniela Grimm |
| author_sort | Stefan Riwaldt |
| collection | DOAJ |
| description | Functioning as the outermost self-renewing protective layer of the human organism, skin protects against a multitude of harmful biological and physical stimuli. Consisting of ectodermal, mesenchymal, and neural crest-derived cell lineages, tissue homeostasis, and signal transduction are finely tuned through the interplay of various pathways. A health problem of astronauts in space is skin deterioration. Until today, wound healing has not been considered as a severe health concern for crew members. This can change with deep space exploration missions and commercial spaceflights together with space tourism. Albeit the molecular process of wound healing is not fully elucidated yet, there have been established significant conceptual gains and new scientific methods. Apoptosis, e.g., programmed cell death, enables orchestrated development and cell removal in wounded or infected tissue. Experimental designs utilizing microgravity allow new insights into the role of apoptosis in wound healing. Furthermore, impaired wound healing in unloading conditions would depict a significant challenge in human-crewed exploration space missions. In this review, we provide an overview of alterations in the behavior of cutaneous cell lineages under microgravity in regard to the impact of apoptosis in wound healing. We discuss the current knowledge about wound healing in space and simulated microgravity with respect to apoptosis and available therapeutic strategies. |
| first_indexed | 2024-12-20T00:52:12Z |
| format | Article |
| id | doaj.art-00f9bbc544d944d49fdf3e9cbcf4bef8 |
| institution | Directory Open Access Journal |
| issn | 2296-4185 |
| language | English |
| last_indexed | 2024-12-20T00:52:12Z |
| publishDate | 2021-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Bioengineering and Biotechnology |
| spelling | doaj.art-00f9bbc544d944d49fdf3e9cbcf4bef82022-12-21T19:59:12ZengFrontiers Media S.A.Frontiers in Bioengineering and Biotechnology2296-41852021-06-01910.3389/fbioe.2021.679650679650Role of Apoptosis in Wound Healing and Apoptosis Alterations in MicrogravityStefan Riwaldt0Thomas J. Corydon1Thomas J. Corydon2Desiré Pantalone3Jayashree Sahana4Petra Wise5Markus Wehland6Markus Wehland7Marcus Krüger8Marcus Krüger9Daniela Melnik10Sascha Kopp11Sascha Kopp12Manfred Infanger13Manfred Infanger14Daniela Grimm15Daniela Grimm16Daniela Grimm17Department of Microgravity and Translational Regenerative Medicine, University Clinic for Plastic, Aesthetic and Hand Surgery, Otto-von-Guericke University, Magdeburg, GermanyDepartment of Biomedicine, Aarhus University, Aarhus, DenmarkDepartment of Ophthalmology, Aarhus University Hospital, Aarhus, DenmarkDepartment of Experimental and Clinical Medicine, University of Florence, Florence, ItalyDepartment of Biomedicine, Aarhus University, Aarhus, DenmarkThe Saban Research Institute, Children's Hospital Los Angeles, University of Southern California, Los Angeles, CA, United StatesDepartment of Microgravity and Translational Regenerative Medicine, University Clinic for Plastic, Aesthetic and Hand Surgery, Otto-von-Guericke University, Magdeburg, GermanyResearch Group “Magdeburger Arbeitsgemeinschaft für Forschung unter Raumfahrt-und Schwerelosigkeitsbedingungen” (MARS), Otto-von-Guericke University, Magdeburg, GermanyDepartment of Microgravity and Translational Regenerative Medicine, University Clinic for Plastic, Aesthetic and Hand Surgery, Otto-von-Guericke University, Magdeburg, GermanyResearch Group “Magdeburger Arbeitsgemeinschaft für Forschung unter Raumfahrt-und Schwerelosigkeitsbedingungen” (MARS), Otto-von-Guericke University, Magdeburg, GermanyDepartment of Microgravity and Translational Regenerative Medicine, University Clinic for Plastic, Aesthetic and Hand Surgery, Otto-von-Guericke University, Magdeburg, GermanyDepartment of Microgravity and Translational Regenerative Medicine, University Clinic for Plastic, Aesthetic and Hand Surgery, Otto-von-Guericke University, Magdeburg, GermanyResearch Group “Magdeburger Arbeitsgemeinschaft für Forschung unter Raumfahrt-und Schwerelosigkeitsbedingungen” (MARS), Otto-von-Guericke University, Magdeburg, GermanyDepartment of Microgravity and Translational Regenerative Medicine, University Clinic for Plastic, Aesthetic and Hand Surgery, Otto-von-Guericke University, Magdeburg, GermanyResearch Group “Magdeburger Arbeitsgemeinschaft für Forschung unter Raumfahrt-und Schwerelosigkeitsbedingungen” (MARS), Otto-von-Guericke University, Magdeburg, GermanyDepartment of Microgravity and Translational Regenerative Medicine, University Clinic for Plastic, Aesthetic and Hand Surgery, Otto-von-Guericke University, Magdeburg, GermanyDepartment of Biomedicine, Aarhus University, Aarhus, DenmarkResearch Group “Magdeburger Arbeitsgemeinschaft für Forschung unter Raumfahrt-und Schwerelosigkeitsbedingungen” (MARS), Otto-von-Guericke University, Magdeburg, GermanyFunctioning as the outermost self-renewing protective layer of the human organism, skin protects against a multitude of harmful biological and physical stimuli. Consisting of ectodermal, mesenchymal, and neural crest-derived cell lineages, tissue homeostasis, and signal transduction are finely tuned through the interplay of various pathways. A health problem of astronauts in space is skin deterioration. Until today, wound healing has not been considered as a severe health concern for crew members. This can change with deep space exploration missions and commercial spaceflights together with space tourism. Albeit the molecular process of wound healing is not fully elucidated yet, there have been established significant conceptual gains and new scientific methods. Apoptosis, e.g., programmed cell death, enables orchestrated development and cell removal in wounded or infected tissue. Experimental designs utilizing microgravity allow new insights into the role of apoptosis in wound healing. Furthermore, impaired wound healing in unloading conditions would depict a significant challenge in human-crewed exploration space missions. In this review, we provide an overview of alterations in the behavior of cutaneous cell lineages under microgravity in regard to the impact of apoptosis in wound healing. We discuss the current knowledge about wound healing in space and simulated microgravity with respect to apoptosis and available therapeutic strategies.https://www.frontiersin.org/articles/10.3389/fbioe.2021.679650/fullskinwound healingapoptosismicrogravitysurgeryspaceflight |
| spellingShingle | Stefan Riwaldt Thomas J. Corydon Thomas J. Corydon Desiré Pantalone Jayashree Sahana Petra Wise Markus Wehland Markus Wehland Marcus Krüger Marcus Krüger Daniela Melnik Sascha Kopp Sascha Kopp Manfred Infanger Manfred Infanger Daniela Grimm Daniela Grimm Daniela Grimm Role of Apoptosis in Wound Healing and Apoptosis Alterations in Microgravity Frontiers in Bioengineering and Biotechnology skin wound healing apoptosis microgravity surgery spaceflight |
| title | Role of Apoptosis in Wound Healing and Apoptosis Alterations in Microgravity |
| title_full | Role of Apoptosis in Wound Healing and Apoptosis Alterations in Microgravity |
| title_fullStr | Role of Apoptosis in Wound Healing and Apoptosis Alterations in Microgravity |
| title_full_unstemmed | Role of Apoptosis in Wound Healing and Apoptosis Alterations in Microgravity |
| title_short | Role of Apoptosis in Wound Healing and Apoptosis Alterations in Microgravity |
| title_sort | role of apoptosis in wound healing and apoptosis alterations in microgravity |
| topic | skin wound healing apoptosis microgravity surgery spaceflight |
| url | https://www.frontiersin.org/articles/10.3389/fbioe.2021.679650/full |
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