The Role of Interleukin-20 in Paclitaxel-Associated Peripheral Neuropathy in Non-Metastatic Breast Cancer Patients Receiving Chemotherapy
Introduction: This study investigated the relationship between serum interleukin-20 (IL-20) levels and paclitaxel-associated neuropathy in patients with non-metastatic breast cancer. Paclitaxel-induced peripheral neuropathy (PIPN) is a significant side effect of paclitaxel chemotherapy, and the exac...
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| Format: | Article |
| Language: | English |
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Galenos Yayinevi
2023-11-01
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| Series: | İstanbul Medical Journal |
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http://istanbulmedicaljournal.org/archives/archive-detail/article-preview/the-role-of-nterleukin-20-in-paclitaxel-associated/63647
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| _version_ | 1797447484065185792 |
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| author | Kubilay Karaboyun Eyyüp Çavdar Yakup İriağaç Ahsen Yılmaz Aliye Çelikkol Okan Avcı Erdoğan Selçuk Şeber |
| author_facet | Kubilay Karaboyun Eyyüp Çavdar Yakup İriağaç Ahsen Yılmaz Aliye Çelikkol Okan Avcı Erdoğan Selçuk Şeber |
| author_sort | Kubilay Karaboyun |
| collection | DOAJ |
| description | Introduction: This study investigated the relationship between serum interleukin-20 (IL-20) levels and paclitaxel-associated neuropathy in patients with non-metastatic breast cancer. Paclitaxel-induced peripheral neuropathy (PIPN) is a significant side effect of paclitaxel chemotherapy, and the exact mechanism underlying PIPN is not fully understood. Methods: This prospective observational study was conducted with non-metastatic breast cancer patients between January 2022 and November 2022. Neuropathy symptoms were evaluated using the QLQ-CIPN20 questionnaire, and serum IL-20 levels were measured at three time points: before chemotherapy, on the 7th day after the first paclitaxel treatment, and after the last treatment. Univariate and multivariate logistic regression analyses were performed to identify factors predicting PIPN. Results: This study was completed with 59 female patients. During the study, 47 patients (79.6%) reported any degree of neuropathy, whereas 12 patients (20.4%) had no neuropathy. Univariate analysis to predict neuropathy measured on day 7 after first paclitaxel administration demonstrated that age, body mass index, 7th-day serum IL-20 level, and last cycle serum IL-20 level were predictive for PIPN. Conclusion: This study demonstrated the relationship between serum IL-20 levels and paclitaxel-related neuropathy in breast cancer patients. Further research targeting the function of IL-20 is needed to investigate potential strategies to prevent and treat PIPN. |
| first_indexed | 2024-03-09T13:56:40Z |
| format | Article |
| id | doaj.art-00fa245f61584df0bf0c7b2538848134 |
| institution | Directory Open Access Journal |
| issn | 2619-9793 2148-094X |
| language | English |
| last_indexed | 2024-03-09T13:56:40Z |
| publishDate | 2023-11-01 |
| publisher | Galenos Yayinevi |
| record_format | Article |
| series | İstanbul Medical Journal |
| spelling | doaj.art-00fa245f61584df0bf0c7b25388481342023-11-30T12:44:52ZengGalenos Yayineviİstanbul Medical Journal2619-97932148-094X2023-11-0124433433910.4274/imj.galenos.2023.5990813049054The Role of Interleukin-20 in Paclitaxel-Associated Peripheral Neuropathy in Non-Metastatic Breast Cancer Patients Receiving ChemotherapyKubilay Karaboyun0Eyyüp Çavdar1Yakup İriağaç2Ahsen Yılmaz3Aliye Çelikkol4Okan Avcı5Erdoğan Selçuk Şeber6 Namık Kemal University Faculty of Medicine, Department of Medical Oncology, Tekirdağ, Turkey Adıyaman Training and Research Hospital, Clinic of Medical Oncology, Adıyaman, Turkey Atatürk City Hospital, Clinic of Medical Oncology, Balıkesir, Turkey Namık Kemal University Faculty of Medicine, Department of Biochemistry, Tekirdağ, Turkey Namık Kemal University Faculty of Medicine, Department of Biochemistry, Tekirdağ, Turkey Namık Kemal University Faculty of Medicine, Department of Medical Oncology, Tekirdağ, Turkey Namık Kemal University Faculty of Medicine, Department of Medical Oncology, Tekirdağ, Turkey Introduction: This study investigated the relationship between serum interleukin-20 (IL-20) levels and paclitaxel-associated neuropathy in patients with non-metastatic breast cancer. Paclitaxel-induced peripheral neuropathy (PIPN) is a significant side effect of paclitaxel chemotherapy, and the exact mechanism underlying PIPN is not fully understood. Methods: This prospective observational study was conducted with non-metastatic breast cancer patients between January 2022 and November 2022. Neuropathy symptoms were evaluated using the QLQ-CIPN20 questionnaire, and serum IL-20 levels were measured at three time points: before chemotherapy, on the 7th day after the first paclitaxel treatment, and after the last treatment. Univariate and multivariate logistic regression analyses were performed to identify factors predicting PIPN. Results: This study was completed with 59 female patients. During the study, 47 patients (79.6%) reported any degree of neuropathy, whereas 12 patients (20.4%) had no neuropathy. Univariate analysis to predict neuropathy measured on day 7 after first paclitaxel administration demonstrated that age, body mass index, 7th-day serum IL-20 level, and last cycle serum IL-20 level were predictive for PIPN. Conclusion: This study demonstrated the relationship between serum IL-20 levels and paclitaxel-related neuropathy in breast cancer patients. Further research targeting the function of IL-20 is needed to investigate potential strategies to prevent and treat PIPN. http://istanbulmedicaljournal.org/archives/archive-detail/article-preview/the-role-of-nterleukin-20-in-paclitaxel-associated/63647 paclitaxelperipheral neuropathybreast canceril-20qlq-cipn20 |
| spellingShingle | Kubilay Karaboyun Eyyüp Çavdar Yakup İriağaç Ahsen Yılmaz Aliye Çelikkol Okan Avcı Erdoğan Selçuk Şeber The Role of Interleukin-20 in Paclitaxel-Associated Peripheral Neuropathy in Non-Metastatic Breast Cancer Patients Receiving Chemotherapy İstanbul Medical Journal paclitaxel peripheral neuropathy breast cancer il-20 qlq-cipn20 |
| title | The Role of Interleukin-20 in Paclitaxel-Associated Peripheral Neuropathy in Non-Metastatic Breast Cancer Patients Receiving Chemotherapy |
| title_full | The Role of Interleukin-20 in Paclitaxel-Associated Peripheral Neuropathy in Non-Metastatic Breast Cancer Patients Receiving Chemotherapy |
| title_fullStr | The Role of Interleukin-20 in Paclitaxel-Associated Peripheral Neuropathy in Non-Metastatic Breast Cancer Patients Receiving Chemotherapy |
| title_full_unstemmed | The Role of Interleukin-20 in Paclitaxel-Associated Peripheral Neuropathy in Non-Metastatic Breast Cancer Patients Receiving Chemotherapy |
| title_short | The Role of Interleukin-20 in Paclitaxel-Associated Peripheral Neuropathy in Non-Metastatic Breast Cancer Patients Receiving Chemotherapy |
| title_sort | role of interleukin 20 in paclitaxel associated peripheral neuropathy in non metastatic breast cancer patients receiving chemotherapy |
| topic | paclitaxel peripheral neuropathy breast cancer il-20 qlq-cipn20 |
| url |
http://istanbulmedicaljournal.org/archives/archive-detail/article-preview/the-role-of-nterleukin-20-in-paclitaxel-associated/63647
|
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