The Small Molecule BIBR1532 Exerts Potential Anti-cancer Activities in Preclinical Models of Feline Oral Squamous Cell Carcinoma Through Inhibition of Telomerase Activity and Down-Regulation of TERT

The Small Molecule BIBR1532 Exerts Potential Anti-cancer Activities in Preclinical Models of Feline Oral Squamous Cell Carcinoma Through Inhibition of Telomerase Activity and Down-Regulation of TERT

Expression of telomerase reverse transcriptase (TERT) and telomerase activity (TA) is a main feature of cancer, contributing to cell immortalization by causing telomeres dysfunction. BIBR1532 is a potent telomerase inhibitor that showed potential anti-tumor activities in several types of cancer, by...

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Bibliographic Details
Main Authors: Gennaro Altamura, Barbara degli Uberti, Giorgio Galiero, Giovanna De Luca, Karen Power, Luca Licenziato, Paola Maiolino, Giuseppe Borzacchiello
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-01-01
Series:Frontiers in Veterinary Science
Subjects:
BIBR1532
telomerase activity
TERT
EGFR
MMP
cancer
Online Access:https://www.frontiersin.org/articles/10.3389/fvets.2020.620776/full

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