Cell-type specific mechanisms of D-serine uptake and release in the brain
Accumulating evidence during the last decade established that D-serine is a key signaling molecule utilized by neurons and astroglia in the mammalian central nervous system. D-serine is increasingly appreciated as the main physiological endogenous coagonist for synaptic NMDA receptors at central exc...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2014-05-01
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| Series: | Frontiers in Synaptic Neuroscience |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fnsyn.2014.00012/full |
| _version_ | 1818020734338859008 |
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| author | Magalie eMartineau Vladimir eParpura Vladimir eParpura Jean-Pierre eMothet |
| author_facet | Magalie eMartineau Vladimir eParpura Vladimir eParpura Jean-Pierre eMothet |
| author_sort | Magalie eMartineau |
| collection | DOAJ |
| description | Accumulating evidence during the last decade established that D-serine is a key signaling molecule utilized by neurons and astroglia in the mammalian central nervous system. D-serine is increasingly appreciated as the main physiological endogenous coagonist for synaptic NMDA receptors at central excitatory synapses; it is mandatory for long-term changes in synaptic strength, memory, learning, and social interactions. Alterations in the extracellular levels of D-serine leading to disrupted cell-cell signaling are a trademark of many chronic or acute neurological (i.e. Alzheimer disease, epilepsy, stroke) and psychiatric (i.e. schizophrenia) disorders, and are associated with addictive behavior (i.e. cocaine addiction). Indeed, fine tuning of the extracellular levels of D-serine, achieved by various molecular machineries and signaling pathways, is necessary for maintenance of accurate NMDA receptor functions. Here, we review the experimental data supporting the notion that astroglia and neurons use different pathways to regulate levels of extracellular D-serine. |
| first_indexed | 2024-04-14T08:08:38Z |
| format | Article |
| id | doaj.art-00fa8b6c79604914a15ce55b6bb5e5d2 |
| institution | Directory Open Access Journal |
| issn | 1663-3563 |
| language | English |
| last_indexed | 2024-04-14T08:08:38Z |
| publishDate | 2014-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Synaptic Neuroscience |
| spelling | doaj.art-00fa8b6c79604914a15ce55b6bb5e5d22022-12-22T02:04:37ZengFrontiers Media S.A.Frontiers in Synaptic Neuroscience1663-35632014-05-01610.3389/fnsyn.2014.0001294877Cell-type specific mechanisms of D-serine uptake and release in the brainMagalie eMartineau0Vladimir eParpura1Vladimir eParpura2Jean-Pierre eMothet3University of MünsterUniversity of Alabama at BirminghamUniversity of RijekaCNRS - Aix Marseille UniversityAccumulating evidence during the last decade established that D-serine is a key signaling molecule utilized by neurons and astroglia in the mammalian central nervous system. D-serine is increasingly appreciated as the main physiological endogenous coagonist for synaptic NMDA receptors at central excitatory synapses; it is mandatory for long-term changes in synaptic strength, memory, learning, and social interactions. Alterations in the extracellular levels of D-serine leading to disrupted cell-cell signaling are a trademark of many chronic or acute neurological (i.e. Alzheimer disease, epilepsy, stroke) and psychiatric (i.e. schizophrenia) disorders, and are associated with addictive behavior (i.e. cocaine addiction). Indeed, fine tuning of the extracellular levels of D-serine, achieved by various molecular machineries and signaling pathways, is necessary for maintenance of accurate NMDA receptor functions. Here, we review the experimental data supporting the notion that astroglia and neurons use different pathways to regulate levels of extracellular D-serine.http://journal.frontiersin.org/Journal/10.3389/fnsyn.2014.00012/fullAstrocytesCalciumExocytosisNeuronsSecretory Vesiclestransporters |
| spellingShingle | Magalie eMartineau Vladimir eParpura Vladimir eParpura Jean-Pierre eMothet Cell-type specific mechanisms of D-serine uptake and release in the brain Frontiers in Synaptic Neuroscience Astrocytes Calcium Exocytosis Neurons Secretory Vesicles transporters |
| title | Cell-type specific mechanisms of D-serine uptake and release in the brain |
| title_full | Cell-type specific mechanisms of D-serine uptake and release in the brain |
| title_fullStr | Cell-type specific mechanisms of D-serine uptake and release in the brain |
| title_full_unstemmed | Cell-type specific mechanisms of D-serine uptake and release in the brain |
| title_short | Cell-type specific mechanisms of D-serine uptake and release in the brain |
| title_sort | cell type specific mechanisms of d serine uptake and release in the brain |
| topic | Astrocytes Calcium Exocytosis Neurons Secretory Vesicles transporters |
| url | http://journal.frontiersin.org/Journal/10.3389/fnsyn.2014.00012/full |
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