Ribonucleotide reductase M2 (RRM2): Regulation, function and targeting strategy in human cancer
Ribonucleotide reductase M2 (RRM2) is a small subunit in ribonucleotide reductases, which participate in nucleotide metabolism and catalyze the conversion of nucleotides to deoxynucleotides, maintaining the dNTP pools for DNA biosynthesis, repair, and replication. RRM2 performs a critical role in th...
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| Format: | Article |
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KeAi Communications Co., Ltd.
2024-01-01
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| Series: | Genes and Diseases |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352304222003245 |
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| author | Zanwen Zuo Zerong Zhou Yuzhou Chang Yan Liu Yuping Shen Qizhang Li Lei Zhang |
| author_facet | Zanwen Zuo Zerong Zhou Yuzhou Chang Yan Liu Yuping Shen Qizhang Li Lei Zhang |
| author_sort | Zanwen Zuo |
| collection | DOAJ |
| description | Ribonucleotide reductase M2 (RRM2) is a small subunit in ribonucleotide reductases, which participate in nucleotide metabolism and catalyze the conversion of nucleotides to deoxynucleotides, maintaining the dNTP pools for DNA biosynthesis, repair, and replication. RRM2 performs a critical role in the malignant biological behaviors of cancers. The structure, regulation, and function of RRM2 and its inhibitors were discussed. RRM2 gene can produce two transcripts encoding the same ORF. RRM2 expression is regulated at multiple levels during the processes from transcription to translation. Moreover, this gene is associated with resistance, regulated cell death, and tumor immunity. In order to develop and design inhibitors of RRM2, appropriate strategies can be adopted based on different mechanisms. Thus, a greater appreciation of the characteristics of RRM2 is a benefit for understanding tumorigenesis, resistance in cancer, and tumor microenvironment. Moreover, RRM2-targeted therapy will be more attention in future therapeutic approaches for enhancement of treatment effects and amelioration of the dismal prognosis. |
| first_indexed | 2024-03-12T15:19:29Z |
| format | Article |
| id | doaj.art-00fb50ba748d4955a6ed690808e318d3 |
| institution | Directory Open Access Journal |
| issn | 2352-3042 |
| language | English |
| last_indexed | 2024-03-12T15:19:29Z |
| publishDate | 2024-01-01 |
| publisher | KeAi Communications Co., Ltd. |
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| series | Genes and Diseases |
| spelling | doaj.art-00fb50ba748d4955a6ed690808e318d32023-08-11T05:34:47ZengKeAi Communications Co., Ltd.Genes and Diseases2352-30422024-01-01111218233Ribonucleotide reductase M2 (RRM2): Regulation, function and targeting strategy in human cancerZanwen Zuo0Zerong Zhou1Yuzhou Chang2Yan Liu3Yuping Shen4Qizhang Li5Lei Zhang6Innovative Drug R&D Center, College of Life Sciences, Huaibei Normal University, Huaibei, Anhui 235000, China; National “111” Center for Cellular Regulation and Molecular Pharmaceutics, Key Laboratory of Fermentation Engineering (Ministry of Education), Hubei Key Laboratory of Industrial Microbiology, Cooperative Innovation Center of Industrial Fermentation (Ministry of Education & Hubei Province), and School of Food and Biological Engineering, Hubei University of Technology, Wuhan, Hubei 430068, ChinaInnovative Drug R&D Center, College of Life Sciences, Huaibei Normal University, Huaibei, Anhui 235000, China; National “111” Center for Cellular Regulation and Molecular Pharmaceutics, Key Laboratory of Fermentation Engineering (Ministry of Education), Hubei Key Laboratory of Industrial Microbiology, Cooperative Innovation Center of Industrial Fermentation (Ministry of Education & Hubei Province), and School of Food and Biological Engineering, Hubei University of Technology, Wuhan, Hubei 430068, ChinaDepartment of Biomedical Informatics, The Ohio State University, Columbus, OH 43210, USASchool of Agriculture and Biology, and Engineering Research Center of Cell & Therapeutic Antibody, Ministry of Education, Shanghai Jiao Tong University, Shanghai 200240, China; Corresponding author.College of Chemistry and Bioengineering, Hunan University of Science and Engineering, Yongzhou, Hunan 425199, China; Corresponding author.Innovative Drug R&D Center, College of Life Sciences, Huaibei Normal University, Huaibei, Anhui 235000, China; National “111” Center for Cellular Regulation and Molecular Pharmaceutics, Key Laboratory of Fermentation Engineering (Ministry of Education), Hubei Key Laboratory of Industrial Microbiology, Cooperative Innovation Center of Industrial Fermentation (Ministry of Education & Hubei Province), and School of Food and Biological Engineering, Hubei University of Technology, Wuhan, Hubei 430068, China; Corresponding author.Innovative Drug R&D Center, College of Life Sciences, Huaibei Normal University, Huaibei, Anhui 235000, China; Department of Pharmaceutical Botany, School of Pharmacy, Naval Medical University, Shanghai 200433, China; Corresponding author.Ribonucleotide reductase M2 (RRM2) is a small subunit in ribonucleotide reductases, which participate in nucleotide metabolism and catalyze the conversion of nucleotides to deoxynucleotides, maintaining the dNTP pools for DNA biosynthesis, repair, and replication. RRM2 performs a critical role in the malignant biological behaviors of cancers. The structure, regulation, and function of RRM2 and its inhibitors were discussed. RRM2 gene can produce two transcripts encoding the same ORF. RRM2 expression is regulated at multiple levels during the processes from transcription to translation. Moreover, this gene is associated with resistance, regulated cell death, and tumor immunity. In order to develop and design inhibitors of RRM2, appropriate strategies can be adopted based on different mechanisms. Thus, a greater appreciation of the characteristics of RRM2 is a benefit for understanding tumorigenesis, resistance in cancer, and tumor microenvironment. Moreover, RRM2-targeted therapy will be more attention in future therapeutic approaches for enhancement of treatment effects and amelioration of the dismal prognosis.http://www.sciencedirect.com/science/article/pii/S2352304222003245FunctionInhibitionRegulationResistanceRRM2 |
| spellingShingle | Zanwen Zuo Zerong Zhou Yuzhou Chang Yan Liu Yuping Shen Qizhang Li Lei Zhang Ribonucleotide reductase M2 (RRM2): Regulation, function and targeting strategy in human cancer Genes and Diseases Function Inhibition Regulation Resistance RRM2 |
| title | Ribonucleotide reductase M2 (RRM2): Regulation, function and targeting strategy in human cancer |
| title_full | Ribonucleotide reductase M2 (RRM2): Regulation, function and targeting strategy in human cancer |
| title_fullStr | Ribonucleotide reductase M2 (RRM2): Regulation, function and targeting strategy in human cancer |
| title_full_unstemmed | Ribonucleotide reductase M2 (RRM2): Regulation, function and targeting strategy in human cancer |
| title_short | Ribonucleotide reductase M2 (RRM2): Regulation, function and targeting strategy in human cancer |
| title_sort | ribonucleotide reductase m2 rrm2 regulation function and targeting strategy in human cancer |
| topic | Function Inhibition Regulation Resistance RRM2 |
| url | http://www.sciencedirect.com/science/article/pii/S2352304222003245 |
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