Ribonucleotide reductase M2 (RRM2): Regulation, function and targeting strategy in human cancer

Ribonucleotide reductase M2 (RRM2): Regulation, function and targeting strategy in human cancer

Ribonucleotide reductase M2 (RRM2) is a small subunit in ribonucleotide reductases, which participate in nucleotide metabolism and catalyze the conversion of nucleotides to deoxynucleotides, maintaining the dNTP pools for DNA biosynthesis, repair, and replication. RRM2 performs a critical role in th...

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Bibliographic Details
Main Authors: Zanwen Zuo, Zerong Zhou, Yuzhou Chang, Yan Liu, Yuping Shen, Qizhang Li, Lei Zhang
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2024-01-01
Series:Genes and Diseases
Subjects:
Function
Inhibition
Regulation
Resistance
RRM2
Online Access:http://www.sciencedirect.com/science/article/pii/S2352304222003245

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