Association of depressive symptoms with chronic liver disease among middle-aged and older adults in China
BackgroundThe relationship between depressive symptoms and chronic liver disease (CLD) is still unclear. We aimed to determine whether depressive symptoms are associated with CLD in a large population sample.MethodsThe data was from the China Health and Retirement Longitudinal Study (CHARLS), an ong...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-10-01
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| Series: | Frontiers in Psychiatry |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpsyt.2023.1273754/full |
| _version_ | 1827784545045315584 |
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| author | Jingke Zeng Xiaohuan Lai Shuigen Wang Dijing Zeng Jiangmin Ye Chunhua Huang Minhua Liu Wenjuan Zhang Hui Xu |
| author_facet | Jingke Zeng Xiaohuan Lai Shuigen Wang Dijing Zeng Jiangmin Ye Chunhua Huang Minhua Liu Wenjuan Zhang Hui Xu |
| author_sort | Jingke Zeng |
| collection | DOAJ |
| description | BackgroundThe relationship between depressive symptoms and chronic liver disease (CLD) is still unclear. We aimed to determine whether depressive symptoms are associated with CLD in a large population sample.MethodsThe data was from the China Health and Retirement Longitudinal Study (CHARLS), an ongoing nationally representative prospective cohort study. Depressive symptoms were assessed with the catchment-area epidemiology survey-depression (CES-D). CLD was identified by the patient’s self-report about a physician’s diagnosis at each visit. Multi-adjusted logistic regression and Cox regression models were used.ResultsA total of 14,995 participants (53.1% female; mean age: 58.85 ± 9.87 years) and 13,405 participants (53.64% female; mean age: 58.58 ± 9.69 years) were included in the cross-sectional and longitudinal analyses, respectively. In the cross-sectional analysis, the odds ratio of CLD in patients with moderate and severe depressive symptoms were 1.46 [95% confidence interval (CI), 1.16–1.83] and 1.78 (95% CI, 1.23–2.56) than those with none/mild depressive symptoms, respectively. In the longitudinal analysis, compared to participants with none/mild depressive symptoms, the hazard rates of CLD in those with moderate and severe depressive symptoms were 1.65 (95%CI, 1.33–2.03) and 1.80 (95%CI, 1.24–2.60). And the 50th percentile difference of time (years) at the incidence of CLD in participants with moderate and severe depressive symptoms were − 0.83 (95%CI, −1.18, −0.49) and − 0.96 (95%CI, −1.56, −0.35), respectively.ConclusionElevated depressive symptoms were associated with an increased risk of CLD among middle-aged and older adults in China. |
| first_indexed | 2024-03-11T16:06:50Z |
| format | Article |
| id | doaj.art-00fd7a158948437284f520fe12852dea |
| institution | Directory Open Access Journal |
| issn | 1664-0640 |
| language | English |
| last_indexed | 2024-03-11T16:06:50Z |
| publishDate | 2023-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Psychiatry |
| spelling | doaj.art-00fd7a158948437284f520fe12852dea2023-10-24T23:34:45ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402023-10-011410.3389/fpsyt.2023.12737541273754Association of depressive symptoms with chronic liver disease among middle-aged and older adults in ChinaJingke Zeng0Xiaohuan Lai1Shuigen Wang2Dijing Zeng3Jiangmin Ye4Chunhua Huang5Minhua Liu6Wenjuan Zhang7Hui Xu8Department of Hepatology, Ganzhou Institute of Liver Diseases, The Fifth People’s Hospital of Ganzhou, Ganzhou, Jiangxi, ChinaDepartment of Hepatology, Ganzhou Institute of Liver Diseases, The Fifth People’s Hospital of Ganzhou, Ganzhou, Jiangxi, ChinaDepartment of Hepatology, Ganzhou Institute of Liver Diseases, The Fifth People’s Hospital of Ganzhou, Ganzhou, Jiangxi, ChinaLongnan First People's Hospital, Ganzhou, Jiangxi Province, ChinaDepartment of Hepatology, Ganzhou Institute of Liver Diseases, The Fifth People’s Hospital of Ganzhou, Ganzhou, Jiangxi, ChinaDepartment of Hepatology, Ganzhou Institute of Liver Diseases, The Fifth People’s Hospital of Ganzhou, Ganzhou, Jiangxi, ChinaDepartment of Hepatology, Ganzhou Institute of Liver Diseases, The Fifth People’s Hospital of Ganzhou, Ganzhou, Jiangxi, ChinaSchool of Basic Medicine, Gannan Medical University, Ganzhou, Jiangxi, ChinaBig Data Center, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, ChinaBackgroundThe relationship between depressive symptoms and chronic liver disease (CLD) is still unclear. We aimed to determine whether depressive symptoms are associated with CLD in a large population sample.MethodsThe data was from the China Health and Retirement Longitudinal Study (CHARLS), an ongoing nationally representative prospective cohort study. Depressive symptoms were assessed with the catchment-area epidemiology survey-depression (CES-D). CLD was identified by the patient’s self-report about a physician’s diagnosis at each visit. Multi-adjusted logistic regression and Cox regression models were used.ResultsA total of 14,995 participants (53.1% female; mean age: 58.85 ± 9.87 years) and 13,405 participants (53.64% female; mean age: 58.58 ± 9.69 years) were included in the cross-sectional and longitudinal analyses, respectively. In the cross-sectional analysis, the odds ratio of CLD in patients with moderate and severe depressive symptoms were 1.46 [95% confidence interval (CI), 1.16–1.83] and 1.78 (95% CI, 1.23–2.56) than those with none/mild depressive symptoms, respectively. In the longitudinal analysis, compared to participants with none/mild depressive symptoms, the hazard rates of CLD in those with moderate and severe depressive symptoms were 1.65 (95%CI, 1.33–2.03) and 1.80 (95%CI, 1.24–2.60). And the 50th percentile difference of time (years) at the incidence of CLD in participants with moderate and severe depressive symptoms were − 0.83 (95%CI, −1.18, −0.49) and − 0.96 (95%CI, −1.56, −0.35), respectively.ConclusionElevated depressive symptoms were associated with an increased risk of CLD among middle-aged and older adults in China.https://www.frontiersin.org/articles/10.3389/fpsyt.2023.1273754/fulldepressive symptomschronic liver diseasemiddle-aged and older adultsChinacohort study |
| spellingShingle | Jingke Zeng Xiaohuan Lai Shuigen Wang Dijing Zeng Jiangmin Ye Chunhua Huang Minhua Liu Wenjuan Zhang Hui Xu Association of depressive symptoms with chronic liver disease among middle-aged and older adults in China Frontiers in Psychiatry depressive symptoms chronic liver disease middle-aged and older adults China cohort study |
| title | Association of depressive symptoms with chronic liver disease among middle-aged and older adults in China |
| title_full | Association of depressive symptoms with chronic liver disease among middle-aged and older adults in China |
| title_fullStr | Association of depressive symptoms with chronic liver disease among middle-aged and older adults in China |
| title_full_unstemmed | Association of depressive symptoms with chronic liver disease among middle-aged and older adults in China |
| title_short | Association of depressive symptoms with chronic liver disease among middle-aged and older adults in China |
| title_sort | association of depressive symptoms with chronic liver disease among middle aged and older adults in china |
| topic | depressive symptoms chronic liver disease middle-aged and older adults China cohort study |
| url | https://www.frontiersin.org/articles/10.3389/fpsyt.2023.1273754/full |
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