Single-cell transcriptomics reveals the effect of PD-L1/TGF-β blockade on the tumor microenvironment

Single-cell transcriptomics reveals the effect of PD-L1/TGF-β blockade on the tumor microenvironment

Abstract Background The anti-tumor activity of anti-PD-1/PD-L1 therapies correlates with T cell infiltration in tumors. Thus, a major goal in oncology is to find strategies that enhance T cell infiltration and efficacy of anti-PD-1/PD-L1 therapy. TGF-β has been shown to contribute to T cell exclusio...

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Bibliographic Details
Main Authors: Yoong Wearn Lim, Garry L. Coles, Savreet K. Sandhu, David S. Johnson, Adam S. Adler, Erica L. Stone
Format: Article
Language:English
Published: BMC 2021-05-01
Series:BMC Biology
Subjects:
PD-L1
TGF-β
Tumor microenvironment
scRNA-seq
Immuno-oncology
Online Access:https://doi.org/10.1186/s12915-021-01034-z

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