The Relationship Between Blood Neutrophil to Lymphocyte Ratio and Tumor Size, Tumor Number, Macrovascular Invasion in Patients with Hepatocellular Carcinoma
Aim: We aimed to show the relationship between blood neutrophil to lymphocyte ratio that is systemic inflammatory marker and tumor size, tumor number, macro-vascular invasion at the time of diagnosis in patients with hepatocellular carcinoma.Methods: A total 48 patients diagnosed with hepatocellular...
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| Format: | Article |
| Language: | English |
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Alanya Alaaddin Keykubat University
2019-10-01
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| Series: | Acta Medica Alanya |
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| Online Access: | https://dergipark.org.tr/en/pub/medalanya/issue/49795/551550?publisher=alku |
| _version_ | 1797907126420504576 |
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| author | Özlem Özer Çakır |
| author_facet | Özlem Özer Çakır |
| author_sort | Özlem Özer Çakır |
| collection | DOAJ |
| description | Aim: We aimed to show the relationship between blood neutrophil to lymphocyte ratio that is systemic inflammatory marker and tumor size, tumor number, macro-vascular invasion at the time of diagnosis in patients with hepatocellular carcinoma.Methods: A total 48 patients diagnosed with hepatocellular carcinoma were included in our study. The patients were divided into two groups according to the median neutrophil to lymphocyte ratio.Results: A total of 48 patients (11 female, 37 male) were included in our study. The mean age of the patients were 67.18±9.51 years-old. The median neutrophil to lym-phocyte ratio was 3.17. There were significant association between neutrophil to lym-phocyte ratio > 3.17 and macrovascular invasion, the tumor number> 3, the tumor size> 5 cm, Child-Turcot-Pugh score, Model for End-stage Liver Disease- Sodium score, C-reactive protein and blood sodium level (p: 0.005, p: 0.009, p< 0.001, p: 0.003, p:0.008, p: 0.035 and p < 0.001, respectively). Multiple logistic lineer regres-sion analysis showed that NLR> 3.17 was an independent predictor of tumor size> 5 cm and hyponatremia in patients with hepatocellular carcinoma (p: 0.010, p: 0.012, respectively).Conclusions: The value of blood neutrophil to lymphocyte ratio at the time of diag-nosis in patients with hepatocellular carcinoma was a good predictor of tumor size and grade of disease. |
| first_indexed | 2024-04-10T10:31:36Z |
| format | Article |
| id | doaj.art-00fda57ede7a4e599165b98b1c44761b |
| institution | Directory Open Access Journal |
| issn | 2587-0319 |
| language | English |
| last_indexed | 2024-04-10T10:31:36Z |
| publishDate | 2019-10-01 |
| publisher | Alanya Alaaddin Keykubat University |
| record_format | Article |
| series | Acta Medica Alanya |
| spelling | doaj.art-00fda57ede7a4e599165b98b1c44761b2023-02-15T16:21:03ZengAlanya Alaaddin Keykubat UniversityActa Medica Alanya2587-03192019-10-013320721210.30565/medalanya.551550727The Relationship Between Blood Neutrophil to Lymphocyte Ratio and Tumor Size, Tumor Number, Macrovascular Invasion in Patients with Hepatocellular CarcinomaÖzlem Özer ÇakırAim: We aimed to show the relationship between blood neutrophil to lymphocyte ratio that is systemic inflammatory marker and tumor size, tumor number, macro-vascular invasion at the time of diagnosis in patients with hepatocellular carcinoma.Methods: A total 48 patients diagnosed with hepatocellular carcinoma were included in our study. The patients were divided into two groups according to the median neutrophil to lymphocyte ratio.Results: A total of 48 patients (11 female, 37 male) were included in our study. The mean age of the patients were 67.18±9.51 years-old. The median neutrophil to lym-phocyte ratio was 3.17. There were significant association between neutrophil to lym-phocyte ratio > 3.17 and macrovascular invasion, the tumor number> 3, the tumor size> 5 cm, Child-Turcot-Pugh score, Model for End-stage Liver Disease- Sodium score, C-reactive protein and blood sodium level (p: 0.005, p: 0.009, p< 0.001, p: 0.003, p:0.008, p: 0.035 and p < 0.001, respectively). Multiple logistic lineer regres-sion analysis showed that NLR> 3.17 was an independent predictor of tumor size> 5 cm and hyponatremia in patients with hepatocellular carcinoma (p: 0.010, p: 0.012, respectively).Conclusions: The value of blood neutrophil to lymphocyte ratio at the time of diag-nosis in patients with hepatocellular carcinoma was a good predictor of tumor size and grade of disease.https://dergipark.org.tr/en/pub/medalanya/issue/49795/551550?publisher=alkunötrofil lenfosit oranıtümör boyutuhepatoselüler karsinomaneutrophil to lymphocyte ratiotumor sizehepatocellular carcinoma |
| spellingShingle | Özlem Özer Çakır The Relationship Between Blood Neutrophil to Lymphocyte Ratio and Tumor Size, Tumor Number, Macrovascular Invasion in Patients with Hepatocellular Carcinoma Acta Medica Alanya nötrofil lenfosit oranı tümör boyutu hepatoselüler karsinoma neutrophil to lymphocyte ratio tumor size hepatocellular carcinoma |
| title | The Relationship Between Blood Neutrophil to Lymphocyte Ratio and Tumor Size, Tumor Number, Macrovascular Invasion in Patients with Hepatocellular Carcinoma |
| title_full | The Relationship Between Blood Neutrophil to Lymphocyte Ratio and Tumor Size, Tumor Number, Macrovascular Invasion in Patients with Hepatocellular Carcinoma |
| title_fullStr | The Relationship Between Blood Neutrophil to Lymphocyte Ratio and Tumor Size, Tumor Number, Macrovascular Invasion in Patients with Hepatocellular Carcinoma |
| title_full_unstemmed | The Relationship Between Blood Neutrophil to Lymphocyte Ratio and Tumor Size, Tumor Number, Macrovascular Invasion in Patients with Hepatocellular Carcinoma |
| title_short | The Relationship Between Blood Neutrophil to Lymphocyte Ratio and Tumor Size, Tumor Number, Macrovascular Invasion in Patients with Hepatocellular Carcinoma |
| title_sort | relationship between blood neutrophil to lymphocyte ratio and tumor size tumor number macrovascular invasion in patients with hepatocellular carcinoma |
| topic | nötrofil lenfosit oranı tümör boyutu hepatoselüler karsinoma neutrophil to lymphocyte ratio tumor size hepatocellular carcinoma |
| url | https://dergipark.org.tr/en/pub/medalanya/issue/49795/551550?publisher=alku |
| work_keys_str_mv | AT ozlemozercakır therelationshipbetweenbloodneutrophiltolymphocyteratioandtumorsizetumornumbermacrovascularinvasioninpatientswithhepatocellularcarcinoma AT ozlemozercakır relationshipbetweenbloodneutrophiltolymphocyteratioandtumorsizetumornumbermacrovascularinvasioninpatientswithhepatocellularcarcinoma |